| Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance LA Kirkman, W Zhan, J Visone, A Dziedziech, PK Singh, H Fan, X Tong, ... Proceedings of the National Academy of Sciences 115 (29), E6863-E6870, 2018 | 80 | 2018 |
| Integrating docking scores, interaction profiles and molecular descriptors to improve the accuracy of molecular docking: toward the discovery of novel Akt1 inhibitors W Zhan, D Li, J Che, L Zhang, B Yang, Y Hu, T Liu, X Dong European journal of medicinal chemistry 75, 11-20, 2014 | 58 | 2014 |
| Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes RLA Santos, L Bai, PK Singh, N Murakami, H Fan, W Zhan, Y Zhu, X Jiang, ... Nature communications 8 (1), 1-11, 2017 | 56 | 2017 |
| Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors W Zhan, Y Li, W Huang, Y Zhao, Z Yao, S Yu, S Yuan, F Jiang, S Yao, S Li Bioorganic & medicinal chemistry 20 (14), 4323-4329, 2012 | 35 | 2012 |
| Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors W Zhan, J Visone, T Ouellette, JC Harris, R Wang, H Zhang, PK Singh, ... Journal of medicinal chemistry 62 (13), 6137-6145, 2019 | 30 | 2019 |
| Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors W Zhan, L Xu, X Dong, J Dong, X Yi, X Ma, N Qiu, J Li, B Yang, Y Zhou, ... European Journal of Medicinal Chemistry 117, 47-58, 2016 | 26 | 2016 |
| Discovery of 3, 4, 6-trisubstituted piperidine derivatives as orally active, low hERG blocking Akt inhibitors via conformational restriction and structure-based design X Dong, W Zhan, M Zhao, J Che, X Dai, Y Wu, L Xu, Y Zhou, Y Zhao, ... Journal of Medicinal Chemistry 62 (15), 7264-7288, 2019 | 25 | 2019 |
| Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice W Zhan, H Zhang, J Ginn, A Leung, YJ Liu, M Michino, A Toita, ... Angewandte Chemie 133 (17), 9365-9369, 2021 | 22 | 2021 |
| Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors W Zhan, J Che, L Xu, Y Wu, X Hu, Y Zhou, G Cheng, Y Hu, X Dong, J Li European journal of medicinal chemistry 180, 72-85, 2019 | 21 | 2019 |
| Structure-based design, synthesis and biological evaluation of diphenylmethylamine derivatives as novel Akt1 inhibitors T Liu, W Zhan, Y Wang, L Zhang, B Yang, X Dong, Y Hu European journal of medicinal chemistry 73, 167-176, 2014 | 21 | 2014 |
| Structure of the human UBR5 E3 ubiquitin ligase F Wang, Q He, W Zhan, Z Yu, E Finkin-Groner, X Ma, G Lin, H Li Structure 31 (5), 541-552. e4, 2023 | 19 | 2023 |
| Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That … J Che, X Dai, J Gao, H Sheng, W Zhan, Y Lu, D Li, Z Gao, Z Jin, B Chen, ... Journal of Medicinal Chemistry 64 (16), 12163-12180, 2021 | 18 | 2021 |
| Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome W Zhan, HC Hsu, T Morgan, T Ouellette, K Burns-Huang, R Hara, ... Journal of medicinal chemistry 62 (20), 9246-9253, 2019 | 16 | 2019 |
| Design, synthesis, biological evaluation, and molecular docking of novel benzopyran and phenylpyrazole derivatives as Akt inhibitors W Zhan, S Lin, J Chen, X Dong, J Chu, W Du Chemical Biology & Drug Design 85 (6), 770-779, 2015 | 14 | 2015 |
| Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM Y Huang, KD Reddy, C Bracken, B Qiu, W Zhan, D Eliezer, O Boudker Journal of the American Chemical Society 145 (15), 8583-8592, 2023 | 13 | 2023 |
| Structure–Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides W Zhan, PK Singh, Y Ban, X Qing, MD Ah Kioon, H Fan, Q Zhao, R Wang, ... Journal of medicinal chemistry 63 (21), 13103-13123, 2020 | 13 | 2020 |
| Phenotypic screening-based identification of 3, 4-disubstituted piperidine derivatives as macrophage M2 polarization modulators: an opportunity for treating multiple sclerosis Q Weng, J Che, Z Zhang, J Zheng, W Zhan, S Lin, T Tian, J Wang, R Gai, ... Journal of Medicinal Chemistry 62 (7), 3268-3285, 2019 | 12 | 2019 |
| Design, synthesis and biological evaluation of novel acrylamide analogues as inhibitors of BCR–ABL kinase S Li, Z Yao, Y Zhao, W Chen, H Wang, X Kuang, W Zhan, S Yao, S Yu, ... Bioorganic & medicinal chemistry letters 22 (16), 5279-5282, 2012 | 11 | 2012 |
| Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome I Deni, BH Stokes, KE Ward, KJ Fairhurst, CFA Pasaje, T Yeo, S Akbar, ... Cell chemical biology 30 (5), 470-485. e6, 2023 | 9 | 2023 |
| Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome H Zhang, HC Hsu, SC Kahne, R Hara, W Zhan, X Jiang, K Burns-Huang, ... Journal of medicinal chemistry 64 (9), 6262-6272, 2021 | 9 | 2021 |
Carl NathanProfessor of Microbiology and Immunology, Weill Cornell Medical College在 med.cornell.edu 的电子邮件经过验证
