Synthon-based ligand discovery in virtual libraries of over 11 billion compounds AA Sadybekov, AV Sadybekov, Y Liu, C Iliopoulos-Tsoutsouvas, ... Nature 601 (7893), 452-459, 2022 | 247 | 2022 |
Structural basis for selectivity and diversity in angiotensin II receptors H Zhang, GW Han, A Batyuk, A Ishchenko, KL White, N Patel, ... Nature 544 (7650), 327-332, 2017 | 234 | 2017 |
Structural basis for ligand recognition and functional selectivity at angiotensin receptor*♦ H Zhang, H Unal, R Desnoyer, GW Han, N Patel, V Katritch, SS Karnik, ... Journal of Biological Chemistry 290 (49), 29127-29139, 2015 | 194 | 2015 |
Structural basis of ligand recognition at the human MT1 melatonin receptor B Stauch, LC Johansson, JD McCorvy, N Patel, GW Han, XP Huang, ... Nature 569 (7755), 284-288, 2019 | 190 | 2019 |
Structural connection between activation microswitch and allosteric sodium site in GPCR signaling KL White, MT Eddy, ZG Gao, GW Han, T Lian, A Deary, N Patel, ... Structure 26 (2), 259-269. e5, 2018 | 153 | 2018 |
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity LC Johansson, B Stauch, JD McCorvy, GW Han, N Patel, XP Huang, ... Nature 569 (7755), 289-292, 2019 | 141 | 2019 |
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists T Claff, J Yu, V Blais, N Patel, C Martin, L Wu, GW Han, BJ Holleran, ... Science advances 5 (11), eaax9115, 2019 | 106 | 2019 |
The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor RL Miller, AA Thompson, C Trapella, R Guerrini, D Malfacini, N Patel, ... Structure 23 (12), 2291-2299, 2015 | 89 | 2015 |
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs A Luginina, A Gusach, E Marin, A Mishin, R Brouillette, P Popov, ... Science advances 5 (10), eaax2518, 2019 | 81 | 2019 |
Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody A Ishchenko, D Wacker, M Kapoor, A Zhang, GW Han, S Basu, N Patel, ... Proceedings of the National Academy of Sciences 114 (31), 8223-8228, 2017 | 70 | 2017 |
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors A Gusach, A Luginina, E Marin, RL Brouillette, É Besserer-Offroy, ... Nature communications 10 (1), 5573, 2019 | 66 | 2019 |
Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor MT Eddy, ZG Gao, P Mannes, N Patel, KA Jacobson, V Katritch, ... Journal of the American Chemical Society 140 (26), 8228-8235, 2018 | 49 | 2018 |
Structure-based discovery of potent and selective melatonin receptor agonists N Patel, XP Huang, JM Grandner, LC Johansson, B Stauch, JD McCorvy, ... Elife 9, e53779, 2020 | 40 | 2020 |
Structural Studies of the Human Kappa Opioid Receptor Active State Conformations MY Lee, N Patel, V Katritch, RC Stevens, V Cherezov Biophysical Journal 110 (3), 38a-39a, 2016 | 1 | 2016 |
Deep Learning for the Structure‐Based Binding Free Energy Prediction of Small Molecule Ligands V Mysore, N Patel, A Ojewole Computational Drug Discovery: Methods and Applications 1, 255-273, 2024 | | 2024 |
Melatonin receptor reveal the basis of subtype selectivity LC Johansson, B Stauch, JD Mccorvy, GW Han, N Patel, XP Huang, ... | | 2019 |