| Single-stranded siRNAs activate RNAi in animals WF Lima, TP Prakash, HM Murray, GA Kinberger, W Li, AE Chappell, ... Cell 150 (5), 883-894, 2012 | 274 | 2012 |
| Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl Nucleic Acid Analogues PP Seth, G Vasquez, CA Allerson, A Berdeja, H Gaus, GA Kinberger, ... The Journal of organic chemistry 75 (5), 1569-1581, 2010 | 248 | 2010 |
| Potent inhibition of microRNA in vivo without degradation S Davis, S Propp, SM Freier, LE Jones, MJ Serra, G Kinberger, B Bhat, ... Nucleic acids research 37 (1), 70-77, 2009 | 241 | 2009 |
| Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides … M Tanowitz, L Hettrick, A Revenko, GA Kinberger, TP Prakash, PP Seth Nucleic acids research 45 (21), 12388-12400, 2017 | 132 | 2017 |
| Comprehensive Structure–Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes TP Prakash, J Yu, MT Migawa, GA Kinberger, WB Wan, ME Østergaard, ... Journal of medicinal chemistry 59 (6), 2718-2733, 2016 | 128 | 2016 |
| Collagen mimetic dendrimers GA Kinberger, W Cai, M Goodman Journal of the American Chemical Society 124 (51), 15162-15163, 2002 | 122 | 2002 |
| Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs PP Seth, A Siwkowski, CR Allerson, G Vasquez, S Lee, TP Prakash, ... Nucleic Acids Symposium Series 52 (1), 553-554, 2008 | 112 | 2008 |
| Oligomer-conjugate complexes and their use TP Prakash, EE Swayze, WF Lima, GA Kinberger US Patent 10,023,861, 2018 | 111 | 2018 |
| Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity TP Prakash, WF Lima, HM Murray, W Li, GA Kinberger, AE Chappell, ... Nucleic acids research 43 (6), 2993-3011, 2015 | 92 | 2015 |
| Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates ME Østergaard, M Jackson, A Low, A E. Chappell, R G. Lee, RQ Peralta, ... Nucleic Acids Research 47 (12), 6045-6058, 2019 | 90 | 2019 |
| Efficient synthesis and biological evaluation of 5′-GalNAc conjugated antisense oligonucleotides ME Østergaard, J Yu, GA Kinberger, WB Wan, MT Migawa, G Vasquez, ... Bioconjugate chemistry 26 (8), 1451-1455, 2015 | 89 | 2015 |
| Structural analysis of human Argonaute-2 bound to a modified siRNA guide NT Schirle, GA Kinberger, HF Murray, WF Lima, TP Prakash, IJ MacRae Journal of the American Chemical Society 138 (28), 8694-8697, 2016 | 82 | 2016 |
| Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor K Schmidt, TP Prakash, AJ Donner, GA Kinberger, HJ Gaus, A Low, ... Nucleic acids research 45 (5), 2294-2306, 2017 | 76 | 2017 |
| Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2′-modifications and enhances antisense activity XH Liang, W Shen, H Sun, GA Kinberger, TP Prakash, JG Nichols, ... Nucleic Acids Research 44 (8), 3892-3907, 2016 | 70 | 2016 |
| Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA TP Prakash, GA Kinberger, HM Murray, A Chappell, S Riney, MJ Graham, ... Bioorganic & medicinal chemistry letters 26 (12), 2817-2820, 2016 | 67 | 2016 |
| Oligomeric compounds and compositions for the use in modulation of microRNAs C Esau, EE Swayze, B Bhat, GA Kinberger US Patent 8,129,515, 2012 | 62 | 2012 |
| Structure− activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid K Albertshofer, AM Siwkowski, EV Wancewicz, CC Esau, T Watanabe, ... Journal of medicinal chemistry 48 (21), 6741-6749, 2005 | 54 | 2005 |
| Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes GA Kinberger, TP Prakash, J Yu, G Vasquez, A Low, A Chappell, ... Bioorganic & Medicinal Chemistry Letters 26 (15), 3690-3693, 2016 | 50 | 2016 |
| The design, synthesis, and characterization of a PAMAM-based triple helical collagen mimetic dendrimer GA Kinberger, JP Taulane, M Goodman Tetrahedron 62 (22), 5280-5286, 2006 | 46 | 2006 |
| Evaluation of basic amphipathic peptides for cellular delivery of antisense peptide nucleic acids MA Maier, CC Esau, AM Siwkowski, EV Wancewicz, K Albertshofer, ... Journal of medicinal chemistry 49 (8), 2534-2542, 2006 | 45 | 2006 |
