Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in A lzheimer's disease transgenic mice A Currais, M Prior, R Dargusch, A Armando, J Ehren, D Schubert, ... Aging cell 13 (2), 379-390, 2014 | 198 | 2014 |
The mitochondrial ATP synthase is a shared drug target for aging and dementia J Goldberg, A Currais, M Prior, W Fischer, C Chiruta, E Ratliff, ... Aging cell 17 (2), e12715, 2018 | 137 | 2018 |
The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease A Currais, T Hortobágyi, S Soriano Aging 1 (4), 363, 2009 | 135 | 2009 |
Functional consequences of age-dependent changes in glutathione status in the brain A Currais, P Maher Antioxidants & redox signaling 19 (8), 813-822, 2013 | 121 | 2013 |
Fisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouse A Currais, C Farrokhi, R Dargusch, A Armando, O Quehenberger, ... The journals of gerontology: series A 73 (3), 299-307, 2018 | 109 | 2018 |
Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain A Currais, W Fischer, P Maher, D Schubert The FASEB Journal 31 (1), 5, 2017 | 106 | 2017 |
Ageing and inflammation–a central role for mitochondria in brain health and disease A Currais Ageing Research Reviews 21, 30-42, 2015 | 103 | 2015 |
Back to the future with phenotypic screening M Prior, C Chiruta, A Currais, J Goldberg, J Ramsey, R Dargusch, ... ACS Chemical Neuroscience 5 (7), 503-513, 2014 | 101 | 2014 |
Elevating acetyl-CoA levels reduces aspects of brain aging A Currais, L Huang, J Goldberg, M Petrascheck, G Ates, A Pinto-Duarte, ... Elife 8, e47866, 2019 | 99 | 2019 |
CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's … G Ates, J Goldberg, A Currais, P Maher Redox Biology 36, 101648, 2020 | 88 | 2020 |
A comprehensive multiomics approach toward understanding the relationship between aging and dementia A Currais, J Goldberg, C Farrokhi, M Chang, M Prior, R Dargusch, ... Aging (Albany NY) 7 (11), 937, 2015 | 82 | 2015 |
Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the presenilin-1 Alzheimer's disease brain B Malik, A Currais, A Andres, C Towlson, D Pitsi, A Nunes, M Niblock, ... Cell Cycle 7 (5), 637-646, 2008 | 82 | 2008 |
Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death L Huang, DB McClatchy, P Maher, Z Liang, JK Diedrich, ... Cell death & disease 11 (10), 828, 2020 | 78 | 2020 |
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids A Currais, O Quehenberger, A M Armando, D Daugherty, P Maher, ... NPJ aging and mechanisms of disease 2 (1), 1-8, 2016 | 78 | 2016 |
Diabetes exacerbates amyloid and neurovascular pathology in aging‐accelerated mice A Currais, M Prior, D Lo, C Jolivalt, D Schubert, P Maher Aging cell 11 (6), 1017-1026, 2012 | 74 | 2012 |
MECP2 coding sequence and 3′ UTR variation in 172 unrelated autistic patients AM Coutinho, G Oliveira, C Katz, J Feng, J Yan, C Yang, C Marques, ... American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144 …, 2007 | 70 | 2007 |
Using the oxytosis/ferroptosis pathway to understand and treat age-associated neurodegenerative diseases P Maher, A Currais, D Schubert Cell chemical biology 27 (12), 1456-1471, 2020 | 68 | 2020 |
Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa W Fischer, A Currais, Z Liang, A Pinto, P Maher Redox Biology 21, 101089, 2019 | 64 | 2019 |
Screening and identification of neuroprotective compounds relevant to Alzheimer׳ s disease from medicinal plants of S. Tomé e Príncipe A Currais, C Chiruta, M Goujon-Svrzic, G Costa, T Santos, MT Batista, ... Journal of ethnopharmacology 155 (1), 830-840, 2014 | 55 | 2014 |
Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders Z Liang, A Currais, D Soriano-Castell, D Schubert, P Maher Pharmacology & therapeutics 221, 107749, 2021 | 43 | 2021 |