| A preclinical overview of metformin for the treatment of type 2 diabetes T Zhou, X Xu, M Du, T Zhao, J Wang Biomedicine & Pharmacotherapy 106, 1227-1235, 2018 | 100 | 2018 |
| Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2, 6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X … X Xu, X Xu, P Liu, Z Zhu, J Chen, H Fu, L Chen, L Hu, X Shen Journal of Biological Chemistry 290 (32), 19888-19899, 2015 | 50 | 2015 |
| LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy X Guo, G Sun, T Zhou, Y Wang, X Xu, X Shi, Z Zhu, V Rukachaisirikul, ... Acta Pharmacologica Sinica 38 (8), 1104-1119, 2017 | 38 | 2017 |
| HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter X Xu, X Shi, Y Chen, T Zhou, J Wang, X Xu, L Chen, L Hu, X Shen Metabolism 85, 126-138, 2018 | 33 | 2018 |
| Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening GH Ma, Y Ye, D Zhang, X Xu, P Si, JL Peng, YL Xiao, RY Cao, YL Yin, ... European Journal of Medicinal Chemistry 124, 981-991, 2016 | 29 | 2016 |
| The role of G protein conformation in receptor–G protein selectivity W Jang, S Lu, X Xu, G Wu, NA Lambert Nature chemical biology 19 (6), 687-694, 2023 | 28 | 2023 |
| Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance X Guo, G Sun, T Zhou, X Xu, Z Zhu, V Rukachaisirikul, L Hu, X Shen Acta Pharmacologica Sinica 37 (10), 1281-1297, 2016 | 25 | 2016 |
| Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice T Du, L Yang, X Xu, X Shi, X Xu, J Lu, J Lv, X Huang, J Chen, H Wang, ... Journal of Endocrinology 240 (2), 195-214, 2019 | 23 | 2019 |
| Design, synthesis, and biological evaluation of novel nonsteroidal farnesoid X receptor (FXR) antagonists: molecular basis of FXR antagonism H Huang, P Si, L Wang, Y Xu, X Xu, J Zhu, H Jiang, W Li, L Chen, J Li ChemMedChem 10 (7), 1184-1199, 2015 | 23 | 2015 |
| BBT improves glucose homeostasis by ameliorating β-cell dysfunction in type 2 diabetic mice X Yao, X Xu, G Wang, M Lei, L Quan, Y Cheng, P Wan, J Zhou, J Chen, ... Journal of Endocrinology 224 (3), 327-341, 2015 | 20 | 2015 |
| Cytosporone derivatives from the endophytic fungus Phomopsis sp. PSU-H188 T Kongprapan, X Xu, V Rukachaisirikul, S Phongpaichit, J Sakayaroj, ... Phytochemistry Letters 22, 219-223, 2017 | 18 | 2017 |
| G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers M Khater, Z Wei, X Xu, W Huang, BL Lokeshwar, NA Lambert, G Wu Journal of Biological Chemistry 296, 2021 | 17 | 2021 |
| Rab43 GTPase directs postsynaptic trafficking and neuron-specific sorting of G protein–coupled receptors Z Wei, X Xu, Y Fang, M Khater, SX Naughton, G Hu, AV Terry, G Wu Journal of Biological Chemistry 296, 2021 | 16 | 2021 |
| Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187 J Choochuay, X Xu, V Rukachaisirikul, P Guedduaythong, S Phongpaichit, ... Phytochemistry Letters 22, 122-127, 2017 | 14 | 2017 |
| DMT efficiently inhibits hepatic gluconeogenesis by regulating the Gαq signaling pathway TT Zhou, F Ma, XF Shi, X Xu, T Du, XD Guo, GH Wang, L Yu, ... Journal of molecular endocrinology 59 (2), 151-169, 2017 | 11 | 2017 |
| Specific motifs mediate post-synaptic and surface transport of G protein-coupled receptors X Xu, Z Wei, G Wu Iscience 25 (1), 2022 | 10 | 2022 |
| FX5 as a non-steroidal GR antagonist improved glucose homeostasis in type 2 diabetic mice via GR/HNF4α/miR-122-5p pathway X Xu, Y Chen, D Zhu, T Zhao, R Xu, J Wang, L Hu, X Shen Aging (Albany NY) 13 (2), 2436, 2021 | 8 | 2021 |
| TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice T Zhou, Y Cheng, W Yan, X Shi, X Xu, J Zhou, J Li, J Chen, X Shen Biochemical and biophysical research communications 499 (4), 948-953, 2018 | 8 | 2018 |
| Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets X Xu, G Wu Trends in pharmacological sciences 44 (2), 98-111, 2023 | 7 | 2023 |
| Human C1orf27 protein interacts with α2A-adrenergic receptor and regulates its anterograde transport X Xu, G Wu Journal of Biological Chemistry 298 (6), 2022 | 7 | 2022 |
