| G4C2 repeat RNA initiates a POM121-mediated reduction in specific nucleoporins in C9orf72 ALS/FTD AN Coyne, BL Zaepfel, L Hayes, B Fitchman, Y Salzberg, EC Luo, ... Neuron 107 (6), 1124-1140. e11, 2020 | 114 | 2020 |
| Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS AN Coyne, I Lorenzini, CC Chou, M Torvund, RS Rogers, A Starr, ... Cell reports 21 (1), 110-125, 2017 | 101 | 2017 |
| Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation AN Coyne, SB Yamada, BB Siddegowda, PS Estes, BL Zaepfel, ... Human molecular genetics 24 (24), 6886-6898, 2015 | 90 | 2015 |
| Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS AN Coyne, V Baskerville, BL Zaepfel, DW Dickson, F Rigo, F Bennett, ... Science translational medicine 13 (604), eabe1923, 2021 | 86 | 2021 |
| Failure to deliver and translate—new insights into RNA dysregulation in ALS AN Coyne, BL Zaepfel, DC Zarnescu Frontiers in cellular neuroscience 11, 243, 2017 | 59 | 2017 |
| Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export L Duan, BL Zaepfel, V Aksenova, M Dasso, JD Rothstein, P Kalab, ... Cell reports 40 (3), 2022 | 37 | 2022 |
| UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction BL Zaepfel, Z Zhang, K Maulding, AN Coyne, W Cheng, LR Hayes, ... Cell reports 34 (13), 2021 | 24 | 2021 |
| Nuclear pore dysfunction in neurodegeneration O Spead, BL Zaepfel, JD Rothstein Neurotherapeutics 19 (4), 1050-1060, 2022 | 18 | 2022 |
| RNA is a double-edged sword in ALS pathogenesis BL Zaepfel, JD Rothstein Frontiers in cellular neuroscience 15, 708181, 2021 | 16 | 2021 |
| Counter-regulation of RNA stability by UPF1 and TDP43 N Gomez, C Hsieh, X Li, M Dykstra, J Waksmacki, C Altheim, Y Bechar, ... bioRxiv, 2024.01. 31.578310, 2024 | | 2024 |
| A robust evaluation of TDP-43, poly GP, cellular pathology, and behavior in a AAV-C9ORF72 (G4C2) 66 mouse model EG Thompson, OM Spead, SC Akerman, C Curcio, BL Zaepfel, E Kent, ... bioRxiv, 2024.08. 27.607409, 2024 | | 2024 |
| Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress BL Zaepfel, JD Rothstein Frontiers in Cell and Developmental Biology 9, 809859, 2021 | | 2021 |
