| Programmable base editing of A• T to G• C in genomic DNA without DNA cleavage NM Gaudelli, AC Komor, HA Rees, MS Packer, AH Badran, DI Bryson, ... Nature 551 (7681), 464-471, 2017 | 3739 | 2017 |
| A deep learning approach to antibiotic discovery JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, ... Cell 180 (4), 688-702. e13, 2020 | 1820 | 2020 |
| CRISPR-based technologies for the manipulation of eukaryotic genomes AC Komor, AH Badran, DR Liu Cell 168 (1), 20-36, 2017 | 1250 | 2017 |
| Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C: G-to-T: A base editors with higher efficiency and product purity AC Komor, KT Zhao, MS Packer, NM Gaudelli, AL Waterbury, LW Koblan, ... Science advances 3 (8), eaao4774, 2017 | 800 | 2017 |
| Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance AH Badran, VM Guzov, Q Huai, MM Kemp, P Vishwanath, W Kain, ... Nature 533 (7601), 58-63, 2016 | 246 | 2016 |
| Clinically relevant mutations in core metabolic genes confer antibiotic resistance AJ Lopatkin, SC Bening, AL Manson, JM Stokes, MA Kohanski, ... Science 371 (6531), eaba0862, 2021 | 241 | 2021 |
| Development of potent in vivo mutagenesis plasmids with broad mutational spectra AH Badran, DR Liu Nature communications 6 (1), 8425, 2015 | 217 | 2015 |
| Negative selection and stringency modulation in phage-assisted continuous evolution JC Carlson, AH Badran, DA Guggiana-Nilo, DR Liu Nature chemical biology 10 (3), 216-222, 2014 | 191 | 2014 |
| Continuous directed evolution of DNA-binding proteins to improve TALEN specificity BP Hubbard, AH Badran, JA Zuris, JP Guilinger, KM Davis, L Chen, ... Nature methods 12 (10), 939-942, 2015 | 146 | 2015 |
| A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations BC Dickinson, MS Packer, AH Badran, DR Liu Nature communications 5 (1), 5352, 2014 | 125 | 2014 |
| Editing the genome without double-stranded DNA breaks AC Komor, AH Badran, DR Liu ACS chemical biology 13 (2), 383-388, 2018 | 123 | 2018 |
| Continuous directed evolution of proteins with improved soluble expression T Wang, AH Badran, TP Huang, DR Liu Nature chemical biology 14 (10), 972-980, 2018 | 112 | 2018 |
| In vivo continuous directed evolution AH Badran, DR Liu Current opinion in chemical biology 24, 1-10, 2015 | 107 | 2015 |
| Direct DNA methylation profiling using methyl binding domain proteins Y Yu, S Blair, D Gillespie, R Jensen, D Myszka, AH Badran, I Ghosh, ... Analytical chemistry 82 (12), 5012-5019, 2010 | 69 | 2010 |
| Synthetic biological circuits within an orthogonal central dogma A Costello, AH Badran Trends in biotechnology 39 (1), 59-71, 2021 | 59 | 2021 |
| Toward a general approach for RNA-templated hierarchical assembly of split-proteins JL Furman, AH Badran, O Ajulo, JR Porter, CI Stains, DJ Segal, I Ghosh Journal of the American Chemical Society 132 (33), 11692-11701, 2010 | 46 | 2010 |
| Negative selection and stringency modulation in continuous evolution systems DR Liu, JC Carlson, AH Badran, KM Esvelt US Patent 10,179,911, 2019 | 42 | 2019 |
| Evaluating the global CpG methylation status of native DNA utilizing a bipartite split-luciferase sensor AH Badran, JL Furman, AS Ma, TJ Comi, JR Porter, I Ghosh Analytical chemistry 83 (18), 7151-7157, 2011 | 42 | 2011 |
| Evolution of TALENs DR Liu, B Hubbard, AH Badran US Patent 10,612,011, 2020 | 36 | 2020 |
| Vector-based mutagenesis system AH Badran, DR Liu US Patent 11,299,729, 2022 | 34 | 2022 |
