Proteases involved in cartilage matrix degradation in osteoarthritis L Troeberg, H Nagase Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1824 (1), 133-145, 2012 | 718 | 2012 |
A guide to the composition and functions of the extracellular matrix NK Karamanos, AD Theocharis, Z Piperigkou, D Manou, A Passi, ... The FEBS journal 288 (24), 6850-6912, 2021 | 499 | 2021 |
ADAMTS and ADAM metalloproteinases in osteoarthritis–looking beyond the ‘usual suspects’ CY Yang, A Chanalaris, L Troeberg Osteoarthritis and cartilage 25 (7), 1000-1009, 2017 | 262 | 2017 |
Extracellular regulation of metalloproteinases K Yamamoto, G Murphy, L Troeberg Matrix Biology 44, 255-263, 2015 | 179 | 2015 |
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1 K Yamamoto, H Okano, W Miyagawa, R Visse, Y Shitomi, S Santamaria, ... Matrix Biology 56, 57-73, 2016 | 176 | 2016 |
Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis MC Miller, HB Manning, A Jain, L Troeberg, J Dudhia, D Essex, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2009 | 159 | 2009 |
Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential … A Jain, J Nanchahal, L Troeberg, P Green, F Brennan Arthritis & Rheumatism 44 (8), 1754-1760, 2001 | 135 | 2001 |
Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases L Troeberg, K Fushimi, R Khokha, H Emonard, P Ghosh, H Nagase The FASEB Journal 22 (10), 3515, 2008 | 129 | 2008 |
Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2· TIMP-2 complex through a thrombospondin-independent mechanism H Emonard, G Bellon, L Troeberg, A Berton, A Robinet, P Henriet, ... Journal of Biological Chemistry 279 (52), 54944-54951, 2004 | 128 | 2004 |
Proteases from Trypanosoma brucei brucei Purification, Characterisation and Interactions with Host Regulatory Molecules L Troeberg, RN Pike, RE Morty, RK Berry, THT Coetzer, ... European journal of biochemistry 238 (3), 728-736, 1996 | 121 | 1996 |
Heparan sulfate as a regulator of inflammation and immunity LE Collins, L Troeberg Journal of leukocyte biology 105 (1), 81-92, 2019 | 108 | 2019 |
LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage K Yamamoto, L Troeberg, SD Scilabra, M Pelosi, CL Murphy, ... The FASEB Journal 27 (2), 511, 2013 | 107 | 2013 |
Chalcone, Acyl Hydrazide, and Related Amides Kill Cultured Trypanosoma brucei brucei L Troeberg, X Chen, TM Flaherty, RE Morty, M Cheng, H Hua, C Springer, ... Molecular Medicine 6, 660-669, 2000 | 101 | 2000 |
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity K Fushimi, L Troeberg, H Nakamura, NH Lim, H Nagase Journal of biological chemistry 283 (11), 6706-6716, 2008 | 99 | 2008 |
Interleukin‐1 acts via the JNK‐2 signaling pathway to induce aggrecan degradation by human chondrocytes HM Ismail, K Yamamoto, TL Vincent, H Nagase, L Troeberg, J Saklatvala Arthritis & rheumatology 67 (7), 1826-1836, 2015 | 96 | 2015 |
Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4 … K Yamamoto, K Owen, AE Parker, SD Scilabra, J Dudhia, DK Strickland, ... Journal of Biological Chemistry 289 (10), 6462-6474, 2014 | 93 | 2014 |
E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A) L Troeberg, M Tanaka, R Wait, YE Shi, K Brew, H Nagase Biochemistry 41 (50), 15025-15035, 2002 | 90 | 2002 |
A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin RE Morty, L Troeberg, RN Pike, R Jones, P Nickel, JD Lonsdale-Eccles, ... FEBS letters 433 (3), 251-256, 1998 | 88 | 1998 |
Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3 L Troeberg, C Lazenbatt, MF Anower-E-Khuda, C Freeman, O Federov, ... Chemistry & biology 21 (10), 1300-1309, 2014 | 87 | 2014 |
Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function C Selvais, L D'Auria, D Tyteca, G Perrot, P Lemoine, L Troeberg, ... The FASEB Journal 25 (8), 2770, 2011 | 87 | 2011 |