Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1408 | 2018 |
Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy E Hollville, RG Carroll, SP Cullen, SJ Martin Molecular cell 55 (3), 451-466, 2014 | 324 | 2014 |
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 JO Early, D Menon, CA Wyse, MP Cervantes-Silva, Z Zaslona, RG Carroll, ... Proceedings of the National Academy of Sciences 115 (36), E8460-E8468, 2018 | 295 | 2018 |
Inflammasome priming in sterile inflammatory disease MN Patel, RG Carroll, S Galván-Peña, EL Mills, R Olden, M Triantafilou, ... Trends in molecular medicine 23 (2), 165-180, 2017 | 264 | 2017 |
An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation RG Carroll, Z Zasłona, S Galván-Peña, EL Koppe, DC Sévin, S Angiari, ... Journal of Biological Chemistry 293 (15), 5509-5521, 2018 | 168 | 2018 |
Malonylation of GAPDH is an inflammatory signal in macrophages S Galván-Peña, RG Carroll, C Newman, EC Hinchy, ... Nature communications 10 (1), 338, 2019 | 167 | 2019 |
Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1 RG Carroll, E Hollville, SJ Martin Cell reports 9 (4), 1538-1553, 2014 | 165 | 2014 |
Caspase-11 promotes allergic airway inflammation Z Zasłona, E Flis, MM Wilk, RG Carroll, EM Palsson-McDermott, ... Nature Communications 11 (1), 1055, 2020 | 67 | 2020 |
Immunometabolism around the Clock RG Carroll, GA Timmons, MP Cervantes-Silva, OD Kennedy, AM Curtis Trends in molecular medicine 25 (7), 612-625, 2019 | 63 | 2019 |
Autophagy in multiple myeloma: what makes you stronger can also kill you RG Carroll, SJ Martin Cancer cell 23 (4), 425-426, 2013 | 39 | 2013 |
The circadian clock protein BMAL1 acts as a metabolic sensor in macrophages to control the production of pro IL-1β GA Timmons, RG Carroll, JR O’Siorain, LE Fagan, E Palsson-McDermott, ... Frontiers in Immunology 12, 700431, 2021 | 34 | 2021 |
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing MP Cervantes-Silva, RG Carroll, MM Wilk, D Moreira, CA Payet, ... Nature Communications 13 (1), 7217, 2022 | 31 | 2022 |
Intertwining roles of circadian and metabolic regulation of the innate immune response SL Cox, JR O’Siorain, LE Fagan, AM Curtis, RG Carroll Seminars in Immunopathology 44 (2), 225-237, 2022 | 14 | 2022 |
Circadian disruption in lung fibroblasts enhances NF‐κB activity to exacerbate neutrophil recruitment SL Cox, JR O'Siorain, Y He, R Lordan, A Naik, SY Tang, S Sengupta, ... The FASEB Journal 37 (2), 2023 | 7 | 2023 |
Aging alters rhythms in immunity AM Curtis, RG Carroll Nature Immunology 23 (2), 153-154, 2022 | | 2022 |
Circadian Rhythms in the Innate Immune System-How the molecular clock shapes inflammation through redox control GA Timmons, RG Carroll, JR O'Siorain, MP Cervantes-Silva, ... Free Radical Biology and Medicine 177, S58, 2021 | | 2021 |
The Role of Bcl-2 Family in Mitochondrial Homeostasis R Carroll Trinity College Dublin, 2015 | | 2015 |
Macrophages have a key role in innate immunity. They respond rapidly to pathogens and subsequently promote an anti-inflammatory phenotype to limit damage and promote tissue … EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... | | |