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Lindsay Clegg
Lindsay Clegg
Group Director, Clinical Pharmacology & Pharmacometrics, AstraZeneca
在 astrazeneca.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Design principles for therapeutic angiogenic materials
PS Briquez, LE Clegg, MM Martino, FM Gabhann, JA Hubbell
Nature Reviews Materials 1 (1), 1-15, 2016
1742016
Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model
LW Clegg, F Mac Gabhann
PLoS Computational Biology 11 (6), 2015
652015
Effects of exenatide and open-label SGLT2 inhibitor treatment, given in parallel or sequentially, on mortality and cardiovascular and renal outcomes in type 2 diabetes …
LE Clegg, RC Penland, S Bachina, DW Boulton, M Thuresson, ...
Cardiovascular Diabetology 18, 1-12, 2019
622019
Covalent attachment of a peptide to the surface of gallium nitride
MS Makowski, DY Zemlyanov, JA Lindsey, JC Bernhard, EM Hagen, ...
Surface science 605 (15-16), 1466-1475, 2011
462011
Molecular mechanism matters: Benefits of mechanistic computational models for drug development
LE Clegg, F Mac Gabhann
Pharmacological research 99, 149-154, 2015
422015
Reduction of cardiovascular risk and improved estimated glomerular filtration rate by SGLT2 inhibitors, including dapagliflozin, is consistent across the class: an analysis of …
LE Clegg, HJL Heerspink, RC Penland, W Tang, DW Boulton, S Bachina, ...
Diabetes Care 42 (2), 318-326, 2019
312019
Systems biology of the microvasculature
LE Clegg, F Mac Gabhann
Integrative Biology 7 (5), 498-512, 2015
292015
A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
LE Clegg, F Mac Gabhann
PLoS computational biology 13 (3), e1005445, 2017
272017
Effect of once‐weekly exenatide on estimated glomerular filtration rate slope depends on baseline renal risk: A post hoc analysis of the EXSCEL trial
AB van der Aart‐van der Beek, LE Clegg, RC Penland, DW Boulton, ...
Diabetes, Obesity and Metabolism 22 (12), 2493-2498, 2020
232020
Systems pharmacology of VEGF165b in peripheral artery disease
LE Clegg, VC Ganta, BH Annex, F Mac Gabhann
CPT: Pharmacometrics & Systems Pharmacology 6 (12), 833-844, 2017
182017
Prediction and validation of exenatide risk marker effects on progression of renal disease: insights from EXSCEL
NMA Idzerda, LE Clegg, AF Hernandez, G Bakris, RC Penland, ...
Diabetes, Obesity and Metabolism 22 (5), 798-806, 2020
132020
Assessing reproducibility and utility of clustering of patients with type 2 diabetes and established CV disease (SAVOR-TIMI 53 trial)
Y Aoki, B Hamrén, LE Clegg, C Stahre, DL Bhatt, I Raz, BM Scirica, ...
PLoS One 16 (11), e0259372, 2021
92021
Cardiovascular and renal safety of metformin in patients with diabetes and moderate or severe chronic kidney disease: Observations from the EXSCEL and SAVOR‐TIMI 53 …
LE Clegg, Y Jing, RC Penland, DW Boulton, AF Hernandez, RR Holman, ...
Diabetes, Obesity and Metabolism 23 (5), 1101-1110, 2021
72021
A computational analysis of pro-angiogenic therapies for peripheral artery disease
LE Clegg, F Mac Gabhann
Integrative Biology 10 (1), 18-33, 2018
52018
Sparse-grid-based adaptive model predictive control of HL60 cellular differentiation
SL Noble, LE Wendel, MM Donahue, GT Buzzard, AE Rundell
IEEE transactions on biomedical engineering 59 (2), 456-463, 2011
52011
394. Consistency of AZD7442 (cilgavimab/tixagevimab) pharmacokinetics across prophylaxis and treatment and adult and pediatric participants: application of population …
LE Clegg, O Stepanov, H Schmidt, VP Reddy, W Tang, M Gibbs, S Sedani, ...
Open Forum Infectious Diseases 10 (Supplement_2), ofad500. 464, 2023
42023
Arterialized collateral capillaries progress from nonreactive to capable of increasing perfusion in an ischemic arteriolar tree
KH Gouin III, SK Hellstrom, LE Clegg, J Cutts, F Mac Gabhann, ...
Microcirculation 25 (3), e12438, 2018
42018
130-LB-Impact of SGLT2 inhibitors (SGLT2i) on cardiovascular (CV) risk and estimated glomerular filtration rate (eGFR) in the EXSCEL placebo group
L Clegg, HL Heerspink, RC Penland, T Weifeng, DW Boulton, S Bachina, ...
American Diabetes Association scientific meeting, 2018
32018
Accelerating therapeutics development during a pandemic: population pharmacokinetics of the long-acting antibody combination AZD7442 (tixagevimab/cilgavimab) in the prophylaxis …
LE Clegg, O Stepanov, H Schmidt, W Tang, H Zhang, C Webber, ...
Antimicrobial Agents and Chemotherapy 68 (5), e01587-23, 2024
22024
Impact of SGLT2 Inhibitors (SGLT2i) on Cardiovascular (CV) Risk and Estimated Glomerular Filtration Rate (eGFR) in the EXSCEL Placebo Group
L Clegg, HL Heerspink, RC Penland, W Tang, DW Boulton, S Bachina, ...
Diabetes 67 (Supplement_1), 130-LB, 2018
22018
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