| Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway LE Huang, J Gu, M Schau, HF Bunn Proceedings of the National Academy of Sciences 95 (14), 7987-7992, 1998 | 2888 | 1998 |
| Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein M Ohh, CW Park, M Ivan, MA Hoffman, TY Kim, LE Huang, N Pavletich, ... Nature cell biology 2 (7), 423-427, 2000 | 1951 | 2000 |
| Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit LE Huang, Z Arany, DM Livingston, HF Bunn Journal of Biological Chemistry 271 (50), 32253-32259, 1996 | 1603 | 1996 |
| An essential role for p300/CBP in the cellular response to hypoxia Z Arany, LE Huang, R Eckner, S Bhattacharya, C Jiang, MA Goldberg, ... Proceedings of the National Academy of Sciences 93 (23), 12969-12973, 1996 | 1059 | 1996 |
| HIF‐1α induces cell cycle arrest by functionally counteracting Myc M Koshiji, Y Kageyama, EA Pete, I Horikawa, JC Barrett, LE Huang The EMBO journal 23 (9), 1949-1956, 2004 | 825 | 2004 |
| Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression X Sun, G He, H Qing, W Zhou, F Dobie, F Cai, M Staufenbiel, LE Huang, ... Proceedings of the National Academy of Sciences 103 (49), 18727-18732, 2006 | 680 | 2006 |
| Hypoxia-inducible factor and its biomedical relevance LE Huang, HF Bunn Journal of Biological Chemistry 278 (22), 19575-19578, 2003 | 510 | 2003 |
| Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α DA Elson, G Thurston, LE Huang, DG Ginzinger, DM McDonald, ... Genes & development 15 (19), 2520-2532, 2001 | 432 | 2001 |
| HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression M Koshiji, KKW To, S Hammer, K Kumamoto, AL Harris, P Modrich, ... Molecular cell 17 (6), 793-803, 2005 | 428 | 2005 |
| Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide: implications for oxygen sensing and signaling LE Huang, WG Willmore, J Gu, MA Goldberg, HF Bunn Journal of Biological Chemistry 274 (13), 9038-9044, 1999 | 425 | 1999 |
| Differential gene up-regulation by hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in HEK293T cells V Wang, DA Davis, M Haque, LE Huang, R Yarchoan Cancer research 65 (8), 3299-3306, 2005 | 419 | 2005 |
| Erythropoietin: a model system for studying oxygen-dependent gene regulation HF Bunn, J Gu, LE Huang, JW Park, H Zhu Journal of Experimental Biology 201 (8), 1197-1201, 1998 | 256 | 1998 |
| The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized … DL Galson, T Tsuchiya, DS Tendler, LE Huang, Y Ren, T Ogura, HF Bunn Molecular and cellular biology, 1995 | 236 | 1995 |
| Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1 DH Shin, YS Chun, DS Lee, LE Huang, JW Park Blood, The Journal of the American Society of Hematology 111 (6), 3131-3136, 2008 | 208 | 2008 |
| Molecular mechanism of Hypoxia-inducible Factor 1α-p300 interaction: A leucine-rich interface regulated by a single cysteine J Gu, J Milligan, LE Huang Journal of Biological Chemistry 276 (5), 3550-3554, 2001 | 189 | 2001 |
| Transient cold shock induces the heat shock response upon recovery at 37 degrees C in human cells. AY Liu, H Bian, LE Huang, YK Lee Journal of Biological Chemistry 269 (20), 14768-14775, 1994 | 184 | 1994 |
| Hypoxia-induced genetic instability—a calculated mechanism underlying tumor progression LE Huang, RS Bindra, PM Glazer, AL Harris Journal of Molecular Medicine 85, 139-148, 2007 | 176 | 2007 |
| Carrot and stick: HIF-α engages c-Myc in hypoxic adaptation LE Huang Cell Death & Differentiation 15 (4), 672-677, 2008 | 170 | 2008 |
| Thiol reducing reagents inhibit the heat shock response. Involvement of a redox mechanism in the heat shock signal transduction pathway. LE Huang, H Zhang, SW Bae, AY Liu Journal of Biological Chemistry 269 (48), 30718-30725, 1994 | 147 | 1994 |
| The phosphorylation status of PAS‐B distinguishes HIF‐1α from HIF‐2α in NBS1 repression KKW To, OA Sedelnikova, M Samons, WM Bonner, LE Huang The EMBO journal 25 (20), 4784-4794, 2006 | 146 | 2006 |
Zolt AranyUniversity of Pennsylvania在 mail.med.upenn.edu 的电子邮件经过验证
