VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease X Guo, XY Sun, D Hu, YJ Wang, H Fujioka, R Vyas, S Chakrapani, ... Nature communications 7 (1), 12646, 2016 | 177 | 2016 |
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease X Zhang, R Wang, D Hu, X Sun, H Fujioka, K Lundberg, ER Chan, ... Science advances 6 (49), eabb8680, 2020 | 109 | 2020 |
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects Y Zhao, X Sun, D Hu, DA Prosdocimo, C Hoppel, MK Jain, ... Nature communications 10 (1), 1371, 2019 | 83 | 2019 |
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity D Hu, X Sun, X Liao, X Zhang, S Zarabi, A Schimmer, Y Hong, C Ford, ... Acta neuropathologica 137, 939-960, 2019 | 78 | 2019 |
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models Y Zhao, D Hu, R Wang, X Sun, P Ropelewski, Z Hubler, K Lundberg, ... Nature communications 13 (1), 1121, 2022 | 43 | 2022 |
Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases X Zhang, D Hu, Y Shang, X Qi Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (4), 165431, 2020 | 34 | 2020 |
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease D Hu, X Sun, A Magpusao, Y Fedorov, M Thompson, B Wang, K Lundberg, ... Nature communications 12 (1), 5305, 2021 | 31 | 2021 |
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress R Jobava, Y Mao, BJ Guan, D Hu, D Krokowski, CW Chen, XE Shu, ... Molecular Cell 81 (20), 4191-4208. e8, 2021 | 22 | 2021 |
Mitochondrial quality control strategies: potential therapeutic targets for neurodegenerative diseases? D Hu, Z Liu, X Qi Frontiers in Neuroscience 15, 746873, 2021 | 20 | 2021 |
UPRmt activation protects against MPP+-induced toxicity in a cell culture model of Parkinson's disease D Hu, Z Liu, X Qi Biochemical and biophysical research communications 569, 17-22, 2021 | 16 | 2021 |
AI is a viable alternative to high throughput screening: a 318-target study Scientific reports 14 (1), 7526, 2024 | 9 | 2024 |
Integrin β3-mediated cell senescence associates with gut inflammation and intestinal degeneration in models of Alzheimer’s disease X Tun, EJ Wang, Z Gao, K Lundberg, R Xu, D Hu International Journal of Molecular Sciences 24 (6), 5697, 2023 | 7 | 2023 |
Quantifying Drp1-Mediated Mitochondrial Fission by Immunostaining in Fixed Cells D Hu, X Qi Dynamin Superfamily GTPases: Methods and Protocols, 197-204, 2020 | 3 | 2020 |
Measuring Drp1 activity in mitochondrial fission in vivo D Hu, X Qi Dynamin Superfamily GTPases: Methods and Protocols, 189-195, 2020 | 3 | 2020 |
Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif I Pérez-Jover, K Rochon, D Hu, M Mahajan, P Madan Mohan, ... Nature Communications 15 (1), 52, 2024 | 1 | 2024 |