Executable cancer models: successes and challenges MA Clarke, J Fisher Nature Reviews Cancer 20 (6), 343-354, 2020 | 48 | 2020 |
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling P Kreuzaler, MA Clarke, EJ Brown, CH Wilson, RM Kortlever, N Piterman, ... Proceedings of the National Academy of Sciences 116 (44), 22399-22408, 2019 | 17 | 2019 |
Using State Space Exploration to Determine How Gene Regulatory Networks Constrain Mutation Order in Cancer Evolution MA Clarke, S Woodhouse, N Piterman, BA Hall, J Fisher Automated Reasoning for Systems Biology and Medicine, 133-153, 2019 | 8 | 2019 |
HOXA9 has the hallmarks of a biological switch with implications in blood cancers L Talarmain, MA Clarke, D Shorthouse, L Cabrera-Cosme, DG Kent, ... Nature Communications 13 (1), 5829, 2022 | 7 | 2022 |
Executable network of SARS-CoV-2-host interaction predicts drug combination treatments R Howell, MA Clarke, AK Reuschl, T Chen, S Abbott-Imboden, M Singer, ... npj Digital Medicine 5 (1), 1-13, 2022 | 7 | 2022 |
Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling R Howell, J Davies, MA Clarke, A Appios, I Mesquita, Y Jayal, ... Science Advances 9 (15), eadd1992, 2023 | 3 | 2023 |
Prognostic hallmarks in AML MA Clarke, J Fisher Nature Biomedical Engineering 3 (11), 847-849, 2019 | 1 | 2019 |
HOXA9 acts as a regulatory switch in acute myeloid leukaemia and myeloproliferative neoplasms L Talarmain, MA Clarke, D Shorthouse, J Fisher, BA Hall bioRxiv, 2021.03. 05.434116, 2021 | | 2021 |
Executable Network of SARS-CoV-2-Host Interaction Predicts Drug Combination Treatments (preprint) R Howell, MA Clarke, AK Reuschl, T Chen, S Abott-Imboden, M Singer, ... | | 2021 |
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling N Piterman, P Kreuzaler, MA Clarke, EJ Brown, CH Wilson, RM Kortlever, ... University of Leicester, 2019 | | 2019 |
Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer MA Clarke | | 2018 |
1 Obligatory tumour heterogeneity driven by Myc overexpression: mechanistic insights and therapeutic strategies P Kreuzaler, M Clarke, E Brown, C Wilson, J Fisher, G Evan ESMO Open 3, A1, 2018 | | 2018 |