Neuroinflammation in Alzheimer's disease MT Heneka, MJ Carson, J El Khoury, GE Landreth, F Brosseron, ... The Lancet Neurology 14 (4), 388-405, 2015 | 5398 | 2015 |
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals P Duewell, H Kono, KJ Rayner, CM Sirois, G Vladimer, FG Bauernfeind, ... Nature 464 (7293), 1357-1361, 2010 | 4025 | 2010 |
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization V Hornung, F Bauernfeind, A Halle, EO Samstad, H Kono, KL Rock, ... Nature immunology 9 (8), 847-856, 2008 | 3370 | 2008 |
IKKε and TBK1 are essential components of the IRF3 signaling pathway KA Fitzgerald, SM McWhirter, KL Faia, DC Rowe, E Latz, DT Golenbock, ... Nature immunology 4 (5), 491-496, 2003 | 3234 | 2003 |
Activation and regulation of the inflammasomes E Latz, TS Xiao, A Stutz Nature Reviews Immunology 13 (6), 397-411, 2013 | 3156 | 2013 |
Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression FG Bauernfeind, G Horvath, A Stutz, ES Alnemri, K MacDonald, D Speert, ... The Journal of Immunology 183 (2), 787-791, 2009 | 2974 | 2009 |
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC V Hornung, A Ablasser, M Charrel-Dennis, F Bauernfeind, G Horvath, ... Nature 458 (7237), 514-518, 2009 | 2812 | 2009 |
The NALP3 inflammasome is involved in the innate immune response to amyloid-β A Halle, V Hornung, GC Petzold, CR Stewart, BG Monks, T Reinheckel, ... Nature immunology 9 (8), 857-865, 2008 | 2709 | 2008 |
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice MT Heneka, MP Kummer, A Stutz, A Delekate, S Schwartz, ... Nature 493 (7434), 674-678, 2013 | 2610 | 2013 |
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases RC Coll, AAB Robertson, JJ Chae, SC Higgins, R Muñoz-Planillo, ... Nature medicine 21 (3), 248-255, 2015 | 2321 | 2015 |
Trained immunity: a program of innate immune memory in health and disease MG Netea, LAB Joosten, E Latz, KHG Mills, G Natoli, HG Stunnenberg, ... Science 352 (6284), aaf1098, 2016 | 2222 | 2016 |
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation J Xue, SV Schmidt, J Sander, A Draffehn, W Krebs, I Quester, D De Nardo, ... Immunity 40 (2), 274-288, 2014 | 2181 | 2014 |
IFI16 is an innate immune sensor for intracellular DNA L Unterholzner, SE Keating, M Baran, KA Horan, SB Jensen, S Sharma, ... Nature immunology 11 (11), 997-1004, 2010 | 1839 | 2010 |
Defining trained immunity and its role in health and disease MG Netea, J Domínguez-Andrés, LB Barreiro, T Chavakis, M Divangahi, ... Nature Reviews Immunology 20 (6), 375-388, 2020 | 1762 | 2020 |
TLR9 signals after translocating from the ER to CpG DNA in the lysosome E Latz, A Schoenemeyer, A Visintin, KA Fitzgerald, BG Monks, CF Knetter, ... Nature immunology 5 (2), 190-198, 2004 | 1741 | 2004 |
Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE J Tian, AM Avalos, SY Mao, B Chen, K Senthil, H Wu, P Parroche, ... Nature immunology 8 (5), 487-496, 2007 | 1660 | 2007 |
LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the toll adapters TRAM and TRIF KA Fitzgerald, DC Rowe, BJ Barnes, DR Caffrey, A Visintin, E Latz, ... The Journal of experimental medicine 198 (7), 1043-1055, 2003 | 1612 | 2003 |
Targeting the NLRP3 inflammasome in inflammatory diseases MSJ Mangan, EJ Olhava, WR Roush, HM Seidel, GD Glick, E Latz Nature reviews Drug discovery 17 (8), 588-606, 2018 | 1529 | 2018 |
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses VAK Rathinam, Z Jiang, SN Waggoner, S Sharma, LE Cole, L Waggoner, ... Nature immunology 11 (5), 395-402, 2010 | 1484 | 2010 |
Innate immune activation in neurodegenerative disease MT Heneka, MP Kummer, E Latz Nature Reviews Immunology 14 (7), 463-477, 2014 | 1451 | 2014 |