Small-molecule–induced DNA damage identifies alternative DNA structures in human genes R Rodriguez, KM Miller, JV Forment, CR Bradshaw, M Nikan, S Britton, ... Nature chemical biology 8 (3), 301-310, 2012 | 708 | 2012 |
Salinomycin kills cancer stem cells by sequestering iron in lysosomes TT Mai, A Hamaï, A Hienzsch, T Cañeque, S Müller, J Wicinski, O Cabaud, ... Nature chemistry 9 (10), 1025-1033, 2017 | 486 | 2017 |
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres R Rodriguez, S Müller, JA Yeoman, C Trentesaux, JF Riou, ... Journal of the American Chemical Society 130 (47), 15758-15759, 2008 | 482 | 2008 |
Chemical inhibition of NAT10 corrects defects of laminopathic cells D Larrieu, S Britton, M Demir, R Rodriguez, SP Jackson Science 344 (6183), 527-532, 2014 | 314 | 2014 |
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression M Bejugam, S Sewitz, PS Shirude, R Rodriguez, R Shahid, ... Journal of the American Chemical Society 129 (43), 12926-12927, 2007 | 304 | 2007 |
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton NS Hegde, DA Sanders, R Rodriguez, S Balasubramanian Nature chemistry 3 (9), 725-731, 2011 | 287 | 2011 |
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands D Koirala, S Dhakal, B Ashbridge, Y Sannohe, R Rodriguez, H Sugiyama, ... Nature chemistry 3 (10), 782-787, 2011 | 236 | 2011 |
Small-molecule-mediated G-quadruplex isolation from human cells S Müller, S Kumari, R Rodriguez, S Balasubramanian Nature chemistry 2 (12), 1095-1098, 2010 | 219 | 2010 |
PML-regulated mitochondrial metabolism enhances chemosensitivity in human ovarian cancers G Gentric, Y Kieffer, V Mieulet, O Goundiam, C Bonneau, F Nemati, ... Cell metabolism 29 (1), 156-173. e10, 2019 | 218 | 2019 |
Selective RNAVersus DNA G-Quadruplex Targeting by In Situ Click Chemistry M Di Antonio, G Biffi, A Mariani, EA Raiber, R Rodriguez, ... Angewandte Chemie (International ed. in English) 51 (44), 11073, 2012 | 181 | 2012 |
G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulate c-KIT Expression in Human Gastric Carcinoma Cells KIE McLuckie, ZAE Waller, DA Sanders, D Alves, R Rodriguez, J Dash, ... Journal of the American Chemical Society 133 (8), 2658-2663, 2011 | 178 | 2011 |
CD44 regulates epigenetic plasticity by mediating iron endocytosis S Müller, F Sindikubwabo, T Cañeque, A Lafon, A Versini, B Lombard, ... Nature chemistry 12 (10), 929-938, 2020 | 162 | 2020 |
Visualizing biologically active small molecules in cells using click chemistry T Cañeque, S Müller, R Rodriguez Nature Reviews Chemistry 2 (9), 202-215, 2018 | 161 | 2018 |
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells S Müller, DA Sanders, M Di Antonio, S Matsis, JF Riou, R Rodriguez, ... Organic & biomolecular chemistry 10 (32), 6537-6546, 2012 | 153 | 2012 |
Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands K Jantos, R Rodriguez, S Ladame, PS Shirude, S Balasubramanian Journal of the American Chemical Society 128 (42), 13662-13663, 2006 | 145 | 2006 |
Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction R Rodriguez, GD Pantoş, DPN Gonçalves, JKM Sanders, ... Angewandte Chemie (International ed. in English) 46 (28), 5405, 2007 | 137 | 2007 |
Click chemistry enables preclinical evaluation of targeted epigenetic therapies DS Tyler, J Vappiani, T Cañeque, EYN Lam, A Ward, O Gilan, YC Chan, ... Science 356 (6345), 1397-1401, 2017 | 131 | 2017 |
Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex A Bugaut, R Rodriguez, S Kumari, STD Hsu, S Balasubramanian Organic & biomolecular chemistry 8 (12), 2771-2776, 2010 | 127 | 2010 |
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry A Bugaut, K Jantos, JL Wietor, R Rodriguez, JKM Sanders, ... Angewandte Chemie (International ed. in English) 47 (14), 2677, 2008 | 126 | 2008 |
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome G Balmus, D Larrieu, AC Barros, C Collins, M Abrudan, M Demir, ... Nature communications 9 (1), 1700, 2018 | 123 | 2018 |