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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis PH Maxwell, MS Wiesener, GW Chang, SC Clifford, EC Vaux, ... Nature 399 (6733), 271-275, 1999 | 6196 | 1999 |
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation ACR Epstein, JM Gleadle, LA McNeill, KS Hewitson, J O'Rourke, DR Mole, ... Cell 107 (1), 43-54, 2001 | 4032 | 2001 |
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis P Carmeliet, Y Dor, JM Herbert, D Fukumura, K Brusselmans, ... Nature 394 (6692), 485-490, 1998 | 3386 | 1998 |
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages KL Talks, H Turley, KC Gatter, PH Maxwell, CW Pugh, PJ Ratcliffe, ... The American journal of pathology 157 (2), 411-421, 2000 | 1772 | 2000 |
Hypoxia-inducible expression of tumor-associated carbonic anhydrases CC Wykoff, NJP Beasley, PH Watson, KJ Turner, J Pastorek, A Sibtain, ... Cancer research 60 (24), 7075-7083, 2000 | 1590 | 2000 |
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth PH Maxwell, GU Dachs, JM Gleadle, LG Nicholls, AL Harris, IJ Stratford, ... Proceedings of the National Academy of Sciences 94 (15), 8104-8109, 1997 | 1411 | 1997 |
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein ME Cockman, N Masson, DR Mole, P Jaakkola, GW Chang, SC Clifford, ... Journal of Biological Chemistry 275 (33), 25733-25741, 2000 | 1393 | 2000 |
Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation N Masson, C Willam, PH Maxwell, CW Pugh, PJ Ratcliffe The EMBO journal, 2001 | 1355 | 2001 |
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma RR Raval, KW Lau, MGB Tran, HM Sowter, SJ Mandriota, JL Li, CW Pugh, ... Molecular and cellular biology, 2005 | 1185 | 2005 |
Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs MS Wiesener, JS Jürgensen, C Rosenberger, C Scholze, JH Hörstrup, ... The FASEB Journal 17 (2), 271-273, 2003 | 1008 | 2003 |
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization M Mazzone, D Dettori, RL de Oliveira, S Loges, T Schmidt, B Jonckx, ... Cell 136 (5), 839-851, 2009 | 930 | 2009 |
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL WC Hon, MI Wilson, K Harlos, TDW Claridge, CJ Schofield, CW Pugh, ... Nature 417 (6892), 975-978, 2002 | 870 | 2002 |
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α MS Wiesener, H Turley, WE Allen, C Willam, KU Eckardt, KL Talks, ... Blood, The Journal of the American Society of Hematology 92 (7), 2260-2268, 1998 | 859 | 1998 |
Expression of hypoxia-inducible factor-1α and-2α in hypoxic and ischemic rat kidneys C Rosenberger, S Mandriota, JS Ju, MS Wiesener, JH Ho, U Frei, ... Journal of the American Society of Nephrology 13 (7), 1721-1732, 2002 | 701 | 2002 |
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2 DA Collier, IATM Ferreira, P Kotagiri, RP Datir, EY Lim, E Touizer, B Meng, ... Nature 596 (7872), 417-422, 2021 | 632 | 2021 |
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron SJ Mandriota, KJ Turner, DR Davies, PG Murray, NV Morgan, HM Sowter, ... Cancer cell 1 (5), 459-468, 2002 | 625 | 2002 |
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia SO Ang, H Chen, K Hirota, VR Gordeuk, J Jelinek, Y Guan, E Liu, ... Nature genetics 32 (4), 614-621, 2002 | 616 | 2002 |
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays A Chen, S Liao, M Cheng, K Ma, L Wu, Y Lai, X Qiu, J Yang, J Xu, S Hao, ... Cell 185 (10), 1777-1792. e21, 2022 | 614 | 2022 |
Activation of the HIF pathway in cancer PH Maxwell, CW Pugh, PJ Ratcliffe Current opinion in genetics & development 11 (3), 293-299, 2001 | 608 | 2001 |