Regulation of p53 function and stability by phosphorylation M Ashcroft, MHG Kubbutat, KH Vousden Molecular and cellular biology 19 (3), 1751-1758, 1999 | 605 | 1999 |
Regulation of p53 stability M Ashcroft, KH Vousden Oncogene 18 (53), 7637-7643, 1999 | 600 | 1999 |
Stress signals utilize multiple pathways to stabilize p53 M Ashcroft, Y Taya, KH Vousden Molecular and cellular biology 20 (9), 3224-3233, 2000 | 487 | 2000 |
Role of hypoxia-inducible factor (HIF)-1α versus HIF-2α in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau … VA Carroll, M Ashcroft Cancer research 66 (12), 6264-6270, 2006 | 454 | 2006 |
Negative and positive regulation of HIF-1: a complex network JI Bárdos, M Ashcroft Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1755 (2), 107-120, 2005 | 437 | 2005 |
A ribonucleotide reductase gene is a transcriptional target of p53 and p73 K Nakano, É Bálint, M Ashcroft, KH Vousden Oncogene 19 (37), 4283-4289, 2000 | 304 | 2000 |
Targeting the hypoxia-inducible factor (HIF) pathway in cancer E Poon, AL Harris, M Ashcroft Expert reviews in molecular medicine 11, e26, 2009 | 299 | 2009 |
Hypoxia‐inducible factor‐1 and oncogenic signalling JI Bárdos, M Ashcroft Bioessays 26 (3), 262-269, 2004 | 290 | 2004 |
Regulation of Mdm2-directed degradation by the C terminus of p53 MHG Kubbutat, RL Ludwig, M Ashcroft, KH Vousden Molecular and cellular biology 18 (10), 5690-5698, 1998 | 280 | 1998 |
Identification of a cryptic nucleolar-localization signal in MDM2 MAE Lohrum, M Ashcroft, MHG Kubbutat, KH Vousden Nature cell biology 2 (3), 179-181, 2000 | 252 | 2000 |
Phosphorylation of HDM2 by Akt M Ashcroft, RL Ludwig, DB Woods, TD Copeland, HO Weber, EJ MacRae, ... Oncogene 21 (13), 1955-1962, 2002 | 240 | 2002 |
HIF-1 reduces ischaemia–reperfusion injury in the heart by targeting the mitochondrial permeability transition pore SG Ong, WH Lee, L Theodorou, K Kodo, SY Lim, DH Shukla, T Briston, ... Cardiovascular research 104 (1), 24-36, 2014 | 189 | 2014 |
Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria LW Thomas, M Ashcroft Cellular and Molecular Life Sciences 76, 1759-1777, 2019 | 188 | 2019 |
Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1α … NM Chau, P Rogers, W Aherne, V Carroll, I Collins, E McDonald, ... Cancer Research 65 (11), 4918-4928, 2005 | 184 | 2005 |
Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-κB pathway and is dependent on p53 phosphorylation CA Pise-Masison, R Mahieux, H Jiang, M Ashcroft, M Radonovich, ... Molecular and Cellular Biology 20 (10), 3377-3386, 2000 | 180 | 2000 |
Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target … H Alam, J Weck, E Maizels, Y Park, EJ Lee, M Ashcroft, ... Endocrinology 150 (2), 915-928, 2009 | 151 | 2009 |
Contribution of two independent MDM2-binding domains in p14ARF to p53 stabilization MAE Lohrum, M Ashcroft, MHG Kubbutat, KH Vousden Current Biology 10 (9), 539-542, 2000 | 137 | 2000 |
Targeting the molecular basis for tumour hypoxia VA Carroll, M Ashcroft Expert reviews in molecular medicine 7 (6), 1-16, 2005 | 131 | 2005 |
Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms CJ Anderson, SF Hoare, M Ashcroft, AE Bilsland, WN Keith Oncogene 25 (1), 61-69, 2006 | 130 | 2006 |
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium EO Pettersen, P Ebbesen, RG Gieling, KJ Williams, L Dubois, P Lambin, ... Journal of enzyme inhibition and medicinal chemistry 30 (5), 689-721, 2015 | 128 | 2015 |