| Novel Cyclopropyl β-Amino Acid Analogues of Pregabalin and Gabapentin That Target the α2-δ Protein JB Schwarz, SE Gibbons, SR Graham, NL Colbry, PR Guzzo, VD Le, ... Journal of medicinal chemistry 48 (8), 3026-3035, 2005 | 96 | 2005 |
| Catalytic, asymmetric synthesis of the carbacephem framework PR Guzzo, MJ Miller The Journal of Organic Chemistry 59 (17), 4862-4867, 1994 | 63 | 1994 |
| Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives K Nacro, CC Zha, PR Guzzo, RJ Herr, D Peace, TD Friedrich Bioorganic & medicinal chemistry 15 (12), 4237-4246, 2007 | 56 | 2007 |
| Discovery of MK-5046, a potent, selective bombesin receptor subtype-3 agonist for the treatment of obesity IK Sebhat, C Franklin, MMC Lo, D Chen, JP Jewell, R Miller, J Pang, ... ACS Medicinal Chemistry Letters 2 (1), 43-47, 2011 | 54 | 2011 |
| Synthesis of a conformationally constrained threonine–valine dipeptide mimetic: design of a potential inhibitor of plasminogen activator inhibitor-1 PR Guzzo, MP Trova, T Inghardt, M Linschoten Tetrahedron Letters 43 (1), 41-43, 2002 | 52 | 2002 |
| Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors C Alstermark, K Amin, SR Dinn, T Elebring, O Fjellström, K Fitzpatrick, ... Journal of Medicinal Chemistry 51 (14), 4315-4320, 2008 | 50 | 2008 |
| Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin BF Molino, S Liu, A Sambandam, PR Guzzo, M Hu, C Zha, K Nacro, ... US Patent 7,956,050, 2011 | 43 | 2011 |
| The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties C Guo, M Hu, RJ DeOrazio, A Usyatinsky, K Fitzpatrick, Z Zhang, ... Bioorganic & medicinal chemistry 22 (13), 3414-3422, 2014 | 41 | 2014 |
| Asymmetric organic synthesis. Radical cyclizations of chiral enamides AG Schultz, PR Guzzo, DM Nowak The Journal of Organic Chemistry 60 (24), 8044-8050, 1995 | 41 | 1995 |
| Preparation of 8-amido-2-dimethylamino-1, 2, 3, 4-tetrahydro-2-dibenzofurans and several fluorinated derivatives via [3, 3]-sigmatropic rearrangement of O-aryloximes PR Guzzo, RN Buckle, M Chou, SR Dinn, ME Flaugh, AD Kiefer, KT Ryter, ... The Journal of organic chemistry 68 (3), 770-778, 2003 | 38 | 2003 |
| Partial Agonism of 5-HT3 Receptors: A Novel Approach to the Symptomatic Treatment of IBS-D NA Moore, BJ Sargent, DD Manning, PR Guzzo ACS Chemical Neuroscience 4 (1), 43-47, 2013 | 37 | 2013 |
| Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity J Liu, S He, T Jian, PH Dobbelaar, IK Sebhat, LS Lin, A Goodman, C Guo, ... Bioorganic & Medicinal Chemistry Letters 20 (7), 2074-2077, 2010 | 33 | 2010 |
| Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof MD Surman, PR Guzzo US Patent 8,697,700, 2014 | 28 | 2014 |
| Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin BF Molino, S Liu, PR Guzzo, JP Beck US Patent 7,541,357, 2009 | 28 | 2009 |
| Inhibitors of glycine transporter-1: potential therapeutics for the treatment of CNS disorders C L Cioffi, P R Guzzo Current Topics in Medicinal Chemistry 16 (29), 3404-3437, 2016 | 27 | 2016 |
| 5-(Pyridinon-1-yl) indazoles and 5-(furopyridinon-5-yl) indazoles as MCH-1 antagonists MD Surman, EE Freeman, JF Grabowski, M Hadden, AJ Henderson, ... Bioorganic & medicinal chemistry letters 20 (23), 7015-7019, 2010 | 27 | 2010 |
| Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity M Hadden, A Goodman, C Guo, PR Guzzo, AJ Henderson, K Pattamana, ... Bioorganic & Medicinal Chemistry Letters 20 (9), 2912-2915, 2010 | 27 | 2010 |
| Initial process development and scale-up of the synthesis of a triple reuptake inhibitor ALB 109780 Q Yang, LG Ulysse, MD McLaws, DK Keefe, BP Haney, C Zha, PR Guzzo, ... Organic Process Research & Development 16 (3), 499-506, 2012 | 26 | 2012 |
| Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists S He, PH Dobbelaar, J Liu, T Jian, IK Sebhat, LS Lin, A Goodman, C Guo, ... Bioorganic & Medicinal Chemistry Letters 20 (6), 1913-1917, 2010 | 26 | 2010 |
| 5-Functionalized indazoles as glucocorticoid receptor agonists M Bai, G Carr, RJ DeOrazio, TD Friedrich, S Dobritsa, K Fitzpatrick, ... Bioorganic & medicinal chemistry letters 20 (10), 3017-3020, 2010 | 25 | 2010 |
