Shear-dependent platelet aggregation: mechanisms and therapeutic opportunities A Rana, E Westein, B Niego, CE Hagemeyer Frontiers in cardiovascular medicine 6, 141, 2019 | 159 | 2019 |
Tissue‐type plasminogen activator requires a co‐receptor to enhance NMDA receptor function AL Samson, ST Nevin, D Croucher, B Niego, PB Daniel, TW Weiss, ... Journal of neurochemistry 107 (4), 1091-1101, 2008 | 144 | 2008 |
t-PA–specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes B Niego, R Freeman, TB Puschmann, AM Turnley, RL Medcalf Blood, The Journal of the American Society of Hematology 119 (20), 4752-4761, 2012 | 114 | 2012 |
Plasmin-dependent modulation of the blood–brain barrier: a major consideration during tPA-induced thrombolysis? B Niego, RL Medcalf Journal of Cerebral Blood Flow & Metabolism 34 (8), 1283-1296, 2014 | 108 | 2014 |
Oncostatin M is a neuroprotective cytokine that inhibits excitotoxic injury in vitro and in vivo TW Weiss, AL Samson, B Niego, PB Daniel, RL Medcalf, TW Weiss, ... The FASEB journal 20 (13), 2369-2371, 2006 | 55 | 2006 |
A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury AL Samson, RJ Borg, B Niego, CHY Wong, PJ Crack, T Yongqing, ... Blood, The Journal of the American Society of Hematology 114 (9), 1937-1946, 2009 | 52 | 2009 |
Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin B Niego, N Lee, P Larsson, TM De Silva, AEL Au, F McCutcheon, ... PLoS One 12 (5), e0177332, 2017 | 46 | 2017 |
Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding C Szydzik, B Niego, G Dalzell, M Knoerzer, F Ball, WS Nesbitt, RL Medcalf, ... RSC advances 6 (91), 87988-87994, 2016 | 36 | 2016 |
Valproic acid selectively increases vascular endothelial tissue‐type plasminogen activator production and reduces thrombus formation in the mouse P Larsson, I Alwis, B Niego, M Sashindranath, P Fogelstrand, MCL Wu, ... Journal of thrombosis and haemostasis 14 (12), 2496-2508, 2016 | 35 | 2016 |
t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions R Freeman, DR Croucher, LO Pedersen, RL Medcalf brain research 1565, 63-73, 2014 | 27 | 2014 |
Applications of nanotechnology in the diagnosis and therapy of stroke LM Landowski, B Niego, BA Sutherland, CE Hagemeyer, DW Howells Seminars in thrombosis and hemostasis 46 (05), 592-605, 2020 | 25 | 2020 |
Thrombin-induced activation of astrocytes in mixed rat hippocampal cultures is inhibited by soluble thrombomodulin B Niego, AL Samson, KU Petersen, RL Medcalf Brain research 1381, 38-51, 2011 | 25 | 2011 |
t-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke DF Draxler, F Lee, H Ho, CB Keragala, RL Medcalf, B Niego Frontiers in immunology 10, 430334, 2019 | 24 | 2019 |
Novel thrombolytic drug based on thrombin cleavable microplasminogen coupled to a single‐chain antibody specific for activated GPIIb/IIIa T Bonnard, Z Tennant, BE Niego, R Kanojia, K Alt, S Jagdale, LS Law, ... Journal of the American Heart Association 6 (2), e004535, 2017 | 24 | 2017 |
Desmoteplase-mediated plasminogen activation and clot lysis are inhibited by the lysine analogue tranexamic acid B Niego, A Horvath, PB Coughlin, MK Pugsley, RL Medcalf Blood Coagulation & Fibrinolysis 19 (4), 322-324, 2008 | 24 | 2008 |
Effective treatment of mouse metastatic prostate cancer by low electric field enhanced chemotherapy A Plotnikov, B Niego, R Ophir, R Korenstein, Y Keisari The Prostate 66 (15), 1620-1630, 2006 | 23 | 2006 |
Bioresponsive polyphenol-based nanoparticles as thrombolytic drug carriers H Yu, JS Palazzolo, J Zhou, Y Hu, B Niego, S Pan, Y Ju, TY Wang, Z Lin, ... ACS Applied Materials & Interfaces 14 (3), 3740-3751, 2022 | 22 | 2022 |
Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis DF Draxler, M Daglas, A Fernando, G Hanafi, F McCutcheon, H Ho, ... Journal of Thrombosis and Haemostasis 17 (12), 2174-2187, 2019 | 18 | 2019 |
Two conserved regions within the tissue‐type plasminogen activator gene promoter mediate regulation by brain‐derived neurotrophic factor PB Daniel, W Lux, AL Samson, WD Schleuning, B Niego, TW Weiss, ... The FEBS journal 274 (9), 2411-2423, 2007 | 18 | 2007 |
Fibrinolysis and the immune response in trauma RL Medcalf, CB Keragala, DF Draxler Seminars in Thrombosis and Hemostasis 46 (02), 176-182, 2020 | 15 | 2020 |