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Chiara Maniaci
Chiara Maniaci
在 dundee.ac.uk 的电子邮件经过验证
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Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel–Lindau (VHL) based …
V Zoppi, SJ Hughes, C Maniaci, A Testa, T Gmaschitz, C Wieshofer, ...
Journal of medicinal chemistry 62 (2), 699-726, 2018
2742018
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
C Maniaci, SJ Hughes, A Testa, W Chen, DJ Lamont, S Rocha, DR Alessi, ...
Nature communications 8 (1), 830, 2017
2602017
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity
S Imaide, KM Riching, N Makukhin, V Vetma, C Whitworth, SJ Hughes, ...
Nature chemical biology 17 (11), 1157-1167, 2021
1262021
Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
M Girardini, C Maniaci, SJ Hughes, A Testa, A Ciulli
Bioorganic & Medicinal Chemistry 27 (12), 2466-2479, 2019
1222019
Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader
H Tovell, A Testa, C Maniaci, H Zhou, AR Prescott, T Macartney, A Ciulli, ...
ACS Chemical Biology 14 (5), 882-892, 2019
1022019
Understanding and improving the membrane permeability of VH032-based PROTACs
VG Klein, CE Townsend, A Testa, M Zengerle, C Maniaci, SJ Hughes, ...
ACS medicinal chemistry letters 11 (9), 1732-1738, 2020
962020
Bifunctional chemical probes inducing protein–protein interactions
C Maniaci, A Ciulli
Current Opinion in Chemical Biology 52, 145-156, 2019
962019
New molecular and therapeutic insights into canine diffuse large B cell lymphoma elucidates the role of the dog as a model for human disease
L Aresu, S Ferraresso, L Marconato, L Cascione, S Napoli, E Gaudio, ...
Blood, The Journal of the American Society of Hematology 132 (Supplement 1 …, 2018
612018
Inducible degradation of target proteins through a tractable affinity-directed protein missile system
LM Simpson, TJ Macartney, A Nardin, LJ Fulcher, S Röth, A Testa, ...
Cell Chemical Biology 27 (9), 1164-1180. e5, 2020
452020
A facile synthesis of ligands for the von Hippel–Lindau E3 ligase
C Steinebach, SA Voell, LP Vu, A Bricelj, I Sosič, G Schnakenburg, ...
Synthesis 52 (17), 2521-2527, 2020
232020
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms
C Grohmann, CM Magtoto, JR Walker, NK Chua, A Gabrielyan, M Hall, ...
Nature Communications 13 (1), 2073, 2022
152022
Translating PROTAC chemical series optimization into functional outcomes underlying BRD7 and BRD9 protein degradation
KM Riching, JD Vasta, SJ Hughes, V Zoppi, C Maniaci, A Testa, M Urh, ...
Current Research in Chemical Biology 1, 100009, 2021
152021
Targeted protein degradation via intramolecular bivalent glues
O Hsia, M Hinterndorfer, AD Cowan, K Iso, T Ishida, R Sundaramoorthy, ...
Nature, 1-8, 2024
132024
An intramolecular bivalent degrader glues an intrinsic BRD4-DCAF16 interaction
O Hsia
bioRxiv, 2023
92023
Homo-PROTACs: Bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun 8: 830
C Maniaci, SJ Hughes, A Testa, W Chen, DJ Lamont, S Rocha, DR Alessi, ...
92017
Trivalent PROTACs enhance protein degradation through cooperativity and avidity
S Imaide, KM Riching, V Vetma, C Whitworth, SJ Hughes, N Trainor, ...
62020
Small molecules
A CIULLI, C MANIACI, SJ HUGHES, A TESTA
52018
The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type
C Tarantelli, E Cannas, H Ekeh, C Moscatello, E Gaudio, L Cascione, ...
Exploration of Targeted Anti-tumor Therapy 2 (6), 586, 2021
42021
DEGRONOPEDIA: a web server for proteome-wide inspection of degrons
NA Szulc, F Stefaniak, M Piechota, A Soszyńska, G Piórkowska, ...
Nucleic Acids Research, gkae238, 2024
22024
Inducible Degradation of Target Proteins Through a Tractable Affinity-Directed PROtein Missile (AdPROM) System
L Simpson, T Macartney, A Nardin, L Fulcher, A Testa, C Maniaci, A Ciulli, ...
Available at SSRN 3552150, 2020
12020
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