关注
Matthew M. Hayward
Matthew M. Hayward
其他姓名Matt Hayward, M. Hayward, M. M. Hayward
Vice President of Drug Discovery, Magnet Biomedicine
在 magnetbio.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors
BR Lanning, LR Whitby, MM Dix, J Douhan, AM Gilbert, EC Hett, ...
Nature chemical biology 10 (9), 760-767, 2014
3652014
Delineating the role of cooperativity in the design of potent PROTACs for BTK
A Zorba, C Nguyen, Y Xu, J Starr, K Borzilleri, J Smith, H Zhu, KA Farley, ...
Proceedings of the National Academy of Sciences 115 (31), E7285-E7292, 2018
3242018
Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors
ME Flanagan, JA Abramite, DP Anderson, A Aulabaugh, UP Dahal, ...
Journal of medicinal chemistry 57 (23), 10072-10079, 2014
2862014
Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer
L Bar-Peled, EK Kemper, RM Suciu, EV Vinogradova, KM Backus, ...
Cell 171 (3), 696-709. e23, 2017
2222017
Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant …
JL Henderson, BL Kormos, MM Hayward, KJ Coffman, J Jasti, ...
Journal of medicinal chemistry 58 (1), 419-432, 2015
1862015
Total synthesis of altohyrtin A (spongistatin 1): part 1
J Guo, KJ Duffy, KL Stevens, PI Dalko, RM Roth, MM Hayward, Y Kishi
Angewandte Chemie International Edition 37 (1‐2), 187-190, 1998
1861998
Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition
JB Telliez, ME Dowty, LU Wang, J Jussif, T Lin, L Li, E Moy, P Balbo, W Li, ...
ACS chemical biology 11 (12), 3442-3451, 2016
1522016
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF …
A Thorarensen, ME Dowty, ME Banker, B Juba, J Jussif, T Lin, F Vincent, ...
Journal of medicinal chemistry 60 (5), 1971-1993, 2017
1362017
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl …
A Fensome, CM Ambler, E Arnold, ME Banker, MF Brown, J Chrencik, ...
Journal of medicinal chemistry 61 (19), 8597-8612, 2018
1292018
A proteome-wide atlas of lysine-reactive chemistry
ME Abbasov, ME Kavanagh, TA Ichu, MR Lazear, Y Tao, VM Crowley, ...
Nature chemistry 13 (11), 1081-1092, 2021
1242021
NAPHTHYL‐AND QUINOLYLLUCIFERIN: GREEN AND RED LIGHT EMITTING FIREFLY LUCIFERIN ANALOGUES
BR BRANCHING, MM HAYWARD, S BAMFORD, P M BRENNAN, ...
Photochemistry and photobiology 49 (5), 689-695, 1989
1211989
Bidirectional binding of the TATA box binding protein to the TATA box
JM Cox, MM Hayward, JF Sanchez, LD Gegnas, S Van Der Zee, ...
Proceedings of the National Academy of Sciences 94 (25), 13475-13480, 1997
991997
Proteome-wide map of targets of T790M-EGFR-directed covalent inhibitors
S Niessen, MM Dix, S Barbas, ZE Potter, S Lu, O Brodsky, S Planken, ...
Cell chemical biology 24 (11), 1388-1400. e7, 2017
882017
Discovery of brain-penetrant, irreversible kynurenine aminotransferase II inhibitors for schizophrenia
AB Dounay, M Anderson, BM Bechle, BM Campbell, MM Claffey, ...
ACS medicinal chemistry letters 3 (3), 187-192, 2012
882012
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
J Schiemer, R Horst, Y Meng, JI Montgomery, Y Xu, X Feng, K Borzilleri, ...
Nature Chemical Biology 17 (2), 152-160, 2021
702021
Discovery of tyrosine kinase 2 (TYK2) inhibitor (PF-06826647) for the treatment of autoimmune diseases
BS Gerstenberger, C Ambler, EP Arnold, ME Banker, MF Brown, JD Clark, ...
Journal of Medicinal Chemistry 63 (22), 13561-13577, 2020
592020
Design and Discovery of a Selective Small Molecule κ Opioid Antagonist (2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF …
PR Verhoest, A Sawant Basak, V Parikh, M Hayward, GW Kauffman, ...
Journal of medicinal chemistry 54 (16), 5868-5877, 2011
572011
Pyrrolo [2, 3-d] pyrimidinyl, pyrrolo [2, 3-b] pyrazinyl and pyrrolo [2, 3-d] pyridinyl acrylamides
A Thorarensen, MF Brown, A Casimiro-Garcia, CHE Ye, JW Coe, ...
US Patent 9,617,258, 2017
512017
Total synthesis of altohyrtin A (Spongistatin 1): Part 2
MM Hayward, RM Roth, KJ Duffy, PI Dalko, KL Stevens, J Guo, Y Kishi
Angewandte Chemie International Edition 37 (1‐2), 190-196, 1998
411998
Identification of phosphorylation consensus sequences and endogenous neuronal substrates of the psychiatric risk kinase TNIK
Q Wang, SP Amato, DM Rubitski, MM Hayward, BL Kormos, PR Verhoest, ...
Journal of Pharmacology and Experimental Therapeutics 356 (2), 410-423, 2016
392016
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