Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease S Sarkar, E Malovic, DS Harishchandra, S Ghaisas, N Panicker, A Charli, ... npj Parkinson's Disease 3 (1), 30, 2017 | 238 | 2017 |
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia N Panicker, S Sarkar, DS Harischandra, M Neal, TI Kam, H Jin, ... Journal of Experimental Medicine 216 (6), 1411-1430, 2019 | 213 | 2019 |
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein DS Harischandra, D Rokad, ML Neal, S Ghaisas, S Manne, S Sarkar, ... Science signaling 12 (572), eaau4543, 2019 | 152 | 2019 |
Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes S Sarkar, E Malovic, DS Harischandra, HA Ngwa, A Ghosh, C Hogan, ... Neurotoxicology 64, 204-218, 2018 | 133 | 2018 |
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells S Sarkar, D Rokad, E Malovic, J Luo, DS Harischandra, H Jin, ... Science Signaling 12 (563), eaat9900, 2019 | 125 | 2019 |
Kv1. 3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease S Sarkar, HM Nguyen, E Malovic, J Luo, M Langley, BN Palanisamy, ... The Journal of Clinical Investigation 130 (8), 4195-4212, 2020 | 107 | 2020 |
Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events N Singh, V Lawana, J Luo, P Phong, A Abdalla, B Palanisamy, D Rokad, ... Neurobiology of disease 117, 82-113, 2018 | 100 | 2018 |
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease R Gordon, N Singh, V Lawana, A Ghosh, DS Harischandra, H Jin, ... Neurobiology of disease 93, 96-114, 2016 | 100 | 2016 |
Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal … DS Harischandra, S Ghaisas, D Rokad, M Zamanian, H Jin, ... Neurotoxicology 64, 267-277, 2018 | 94 | 2018 |
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation D Rokad, S Ghaisas, DS Harischandra, H Jin, V Anantharam, ... Brain research bulletin 133, 60-70, 2017 | 63 | 2017 |
Exosomes in toxicology: relevance to chemical exposure and pathogenesis of environmentally linked diseases DS Harischandra, S Ghaisas, D Rokad, AG Kanthasamy Toxicological Sciences 158 (1), 3-13, 2017 | 52 | 2017 |
Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease DS Harischandra, D Rokad, S Ghaisas, S Verma, A Robertson, H Jin, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (4), 165533, 2020 | 31 | 2020 |
Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults S Sarkar, E Malovic, D Sarda, V Lawana, D Rokad, H Jin, V Anantharam, ... Neurotoxicology 67, 129-140, 2018 | 31 | 2018 |
Exosomes as mediators of chemical-induced toxicity D Rokad, H Jin, V Anantharam, A Kanthasamy, AG Kanthasamy Current environmental health reports 6, 73-79, 2019 | 22 | 2019 |
Disruption of intracellular signaling A Kanthasamy, J Luo, D Rokad, A Charli An Introduction to Interdisciplinary Toxicology, 81-96, 2020 | 3 | 2020 |
Epitranscriptomic reader YTHDF2 regulates SEK1 (MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress E Malovic, A Ealy, C Miller, A Jang, PJ Hsu, S Sarkar, D Rokad, C Goeser, ... Iscience 27 (9), 2024 | | 2024 |
Role of Manganese Toxicity on Endosomal Trafficking, Exosomal Proteins and Potential Biomarkers Identification for Parkinson’s Disease DD Rokad Iowa State University, 2020 | | 2020 |
Manganese Exposure Induces the Release of Exosomes Containing Misfolded alpha-Synuclein by Impairing Endosomal Trafficking and Protein Degradation Machinery DD Rokad, D Harischandra, D Luo, S Sarkar, VJ Lawana, D Kim, H Jin, ... International Journal of Toxicology 39 (1), 48-48, 2020 | | 2020 |
Role of neurotoxicants and traumatic brain injury in-synuclein protein misfolding and aggregation D Rokad, S Ghaisas, DS Harischandra, H Jin, V Anantharam, ... | | 2016 |