Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression X Wang, G Sun, T Feng, J Zhang, X Huang, T Wang, Z Xie, X Chu, J Yang, ... Cell research 29 (10), 787-803, 2019 | 871 | 2019 |
Alzheimer’s disease hypothesis and related therapies X Du, X Wang, M Geng Translational neurodegeneration 7, 1-7, 2018 | 595 | 2018 |
Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy F Liu, X Yang, M Geng, M Huang Acta pharmaceutica sinica B 8 (4), 552-562, 2018 | 407 | 2018 |
Molecularly targeted cancer therapy: some lessons from the past decade M Huang, A Shen, J Ding, M Geng Trends in pharmacological sciences 35 (1), 41-50, 2014 | 379 | 2014 |
Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease Q Nie, X Du, M Geng Acta Pharmacologica Sinica 32 (5), 545-551, 2011 | 263 | 2011 |
Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms Y Fan, J Hu, J Li, Z Yang, X Xin, J Wang, J Ding, M Geng Neuroscience letters 374 (3), 222-226, 2005 | 203 | 2005 |
Targeting epigenetic crosstalk as a therapeutic strategy for EZH2-aberrant solid tumors X Huang, J Yan, M Zhang, Y Wang, Y Chen, X Fu, R Wei, X Zheng, Z Liu, ... Cell 175 (1), 186-199. e19, 2018 | 183 | 2018 |
Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation Q Lian, J Xu, S Yan, M Huang, H Ding, X Sun, A Bi, J Ding, B Sun, ... Cell Research 27 (6), 784-800, 2017 | 175 | 2017 |
Emerging cancer therapeutic opportunities target DNA-repair systems J Ding, ZH Miao, LH Meng, MY Geng Trends in pharmacological sciences 27 (6), 338-344, 2006 | 157 | 2006 |
Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling S Wang, X Huang, D Sun, X Xin, Q Pan, S Peng, Z Liang, C Luo, Y Yang, ... PloS one 7 (5), e37427, 2012 | 151 | 2012 |
A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia S Xiao, P Chan, T Wang, Z Hong, S Wang, W Kuang, J He, X Pan, Y Zhou, ... Alzheimer's Research & Therapy 13, 1-11, 2021 | 138 | 2021 |
Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine790→ methionine790 mutant S Chang, L Zhang, S Xu, J Luo, X Lu, Z Zhang, T Xu, Y Liu, Z Tu, Y Xu, ... Journal of Medicinal Chemistry 55 (6), 2711-2723, 2012 | 138 | 2012 |
Feedback activation of leukemia inhibitory factor receptor limits response to histone deacetylase inhibitors in breast cancer H Zeng, J Qu, N Jin, J Xu, C Lin, Y Chen, X Yang, X He, S Tang, X Lan, ... Cancer cell 30 (3), 459-473, 2016 | 135 | 2016 |
A novel long non-coding RNA-ARA: adriamycin resistance associated M Jiang, O Huang, Z Xie, S Wu, X Zhang, A Shen, H Liu, X Chen, J Wu, ... Biochemical pharmacology 87 (2), 254-283, 2014 | 128 | 2014 |
Synthesis and c-Met kinase inhibition of 3, 5-disubstituted and 3, 5, 7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7 … Y Wang, J Ai, Y Wang, Y Chen, L Wang, G Liu, M Geng, A Zhang Journal of medicinal chemistry 54 (7), 2127-2142, 2011 | 125 | 2011 |
Oligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis H Zhao, H Liu, Y Chen, X Xin, J Li, Y Hou, Z Zhang, X Zhang, C Xie, ... Cancer research 66 (17), 8779-8787, 2006 | 125 | 2006 |
Curcumin induces cell death and restores tamoxifen sensitivity in the antiestrogen-resistant breast cancer cell lines MCF-7/LCC2 and MCF-7/LCC9 M Jiang, O Huang, X Zhang, Z Xie, A Shen, H Liu, M Geng, K Shen Molecules 18 (1), 701-720, 2013 | 120 | 2013 |
Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin YG Tong, XW Zhang, MY Geng, JM Yue, XL Xin, F Tian, X Shen, LJ Tong, ... Molecular Pharmacology 69 (4), 1226-1233, 2006 | 114 | 2006 |
Aspirin inhibits cancer metastasis and angiogenesis via targeting heparanase X Dai, J Yan, X Fu, Q Pan, D Sun, Y Xu, J Wang, L Nie, L Tong, A Shen, ... Clinical Cancer Research 23 (20), 6267-6278, 2017 | 107 | 2017 |
One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody–drug conjugates F Tang, Y Yang, Y Tang, S Tang, L Yang, B Sun, B Jiang, J Dong, H Liu, ... Organic & biomolecular chemistry 14 (40), 9501-9518, 2016 | 104 | 2016 |