Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 ME Patti, AJ Butte, S Crunkhorn, K Cusi, R Berria, S Kashyap, Y Miyazaki, ... Proceedings of the national academy of sciences 100 (14), 8466-8471, 2003 | 2289 | 2003 |
Gene regulation and DNA damage in the ageing human brain T Lu, Y Pan, SY Kao, C Li, I Kohane, J Chan, BA Yankner Nature 429 (6994), 883-891, 2004 | 2012 | 2004 |
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression NR Wray, S Ripke, M Mattheisen, M Trzaskowski, EM Byrne, A Abdellaoui, ... Nature genetics 50 (5), 668-681, 2018 | 1989 | 2018 |
Comprehensive genomic characterization defines human glioblastoma genes and core pathways Cancer Genome Atlas Research Network Tissue source sites: Duke University ... Nature 455 (7216), 1061-1068, 2008 | 1946 | 2008 |
Machine learning in medicine A Rajkomar, J Dean, I Kohane New England Journal of Medicine 380 (14), 1347-1358, 2019 | 1687 | 2019 |
Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements AJ Butte, IS Kohane Biocomputing 2000, 418-429, 1999 | 1350 | 1999 |
Artificial intelligence in healthcare KH Yu, AL Beam, IS Kohane Nature biomedical engineering 2 (10), 719-731, 2018 | 1306 | 2018 |
Toward precision medicine: building a knowledge network for biomedical research and a new taxonomy of disease National Research Council National Academies Press, 2011 | 1190* | 2011 |
A mega-analysis of genome-wide association studies for major depressive disorder Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium Molecular psychiatry 18 (4), 2013 | 1179 | 2013 |
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers SL Carter, AC Eklund, IS Kohane, LN Harris, Z Szallasi Nature genetics 38 (9), 1043-1048, 2006 | 1168 | 2006 |
Big data and machine learning in health care AL Beam, IS Kohane Jama 319 (13), 1317-1318, 2018 | 1142 | 2018 |
Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2) SN Murphy, G Weber, M Mendis, V Gainer, HC Chueh, S Churchill, ... Journal of the American Medical Informatics Association 17 (2), 124-130, 2010 | 941 | 2010 |
Discovering statistically significant pathways in expression profiling studies L Tian, SA Greenberg, SW Kong, J Altschuler, IS Kohane, PJ Park Proceedings of the National Academy of Sciences 102 (38), 13544-13549, 2005 | 802 | 2005 |
Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks AJ Butte, P Tamayo, D Slonim, TR Golub, IS Kohane Proceedings of the National Academy of Sciences 97 (22), 12182-12186, 2000 | 774 | 2000 |
Safety of the BNT162b2 mRNA Covid-19 vaccine in a nationwide setting N Barda, N Dagan, Y Ben-Shlomo, E Kepten, J Waxman, R Ohana, ... New England Journal of Medicine, 2021 | 710 | 2021 |
Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study N Barda, N Dagan, C Cohen, MA Hernán, M Lipsitch, IS Kohane, BY Reis, ... The Lancet 398 (10316), 2093-2100, 2021 | 672 | 2021 |
Human disease classification in the postgenomic era: a complex systems approach to human pathobiology J Loscalzo, I Kohane, AL Barabasi Molecular systems biology 3 (1), 124, 2007 | 651 | 2007 |
Analysis of matched mRNA measurements from two different microarray technologies WP Kuo, TK Jenssen, AJ Butte, L Ohno-Machado, IS Kohane Bioinformatics 18 (3), 405-412, 2002 | 608 | 2002 |
Adversarial attacks on medical machine learning SG Finlayson, JD Bowers, J Ito, JL Zittrain, AL Beam, IS Kohane Science 363 (6433), 1287-1289, 2019 | 600 | 2019 |
Genetic misdiagnoses and the potential for health disparities AK Manrai, BH Funke, HL Rehm, MS Olesen, BA Maron, P Szolovits, ... New England Journal of Medicine 375 (7), 655-665, 2016 | 589 | 2016 |