| Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions T Schlothauer, S Herter, CF Koller, S Grau-Richards, V Steinhart, C Spick, ... Protein Engineering, Design and Selection 29 (10), 457-466, 2016 | 310 | 2016 |
| Antibody fc variants M Baehner, S Jenewein, M Kubbies, E Moessner, T Schlothauer US Patent 8,969,526, 2015 | 273 | 2015 |
| Determination of critical quality attributes for monoclonal antibodies using quality by design principles N Alt, TY Zhang, P Motchnik, R Taticek, V Quarmby, T Schlothauer, ... Biologicals 44 (5), 291-305, 2016 | 268 | 2016 |
| In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity M Thomann, T Schlothauer, T Dashivets, S Malik, C Avenal, P Bulau, ... PloS one 10 (8), e0134949, 2015 | 221 | 2015 |
| Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes M Haberger, K Bomans, K Diepold, M Hook, J Gassner, T Schlothauer, ... MAbs 6 (2), 327-339, 2014 | 162 | 2014 |
| Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies T Schlothauer, P Rueger, JO Stracke, H Hertenberger, F Fingas, L Kling, ... MAbs 5 (4), 576-586, 2013 | 136 | 2013 |
| Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures K Diepold, K Bomans, M Wiedmann, B Zimmermann, A Petzold, ... PloS one 7 (1), e30295, 2012 | 134 | 2012 |
| Multi-angle effector function analysis of human monoclonal IgG glycovariants T Dashivets, M Thomann, P Rueger, A Knaupp, J Buchner, T Schlothauer PloS one 10 (12), e0143520, 2015 | 111 | 2015 |
| Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry PF Jensen, V Larraillet, T Schlothauer, H Kettenberger, M Hilger, ... Molecular & Cellular Proteomics 14 (1), 148-161, 2015 | 99 | 2015 |
| A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies J Stracke, T Emrich, P Rueger, T Schlothauer, L Kling, A Knaupp, ... MAbs 6 (5), 1229-1242, 2014 | 99 | 2014 |
| A human endothelial cell-based recycling assay for screening of FcRn targeted molecules A Grevys, J Nilsen, KMK Sand, MB Daba, I Øynebråten, M Bern, ... Nature Communications 9 (1), 621, 2018 | 72 | 2018 |
| Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions I Schmid, L Bonnington, M Gerl, K Bomans, AL Thaller, K Wagner, ... Communications biology 1 (1), 28, 2018 | 70 | 2018 |
| Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies T Dashivets, J Stracke, S Dengl, A Knaupp, J Pollmann, J Buchner, ... MAbs 8 (8), 1525-1535, 2016 | 56 | 2016 |
| An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics M Bern, J Nilsen, M Ferrarese, KMK Sand, TT Gjølberg, HE Lode, ... Science translational medicine 12 (565), eabb0580, 2020 | 49 | 2020 |
| Conformational destabilization of immunoglobulin G increases the low pH binding affinity with the neonatal Fc receptor BT Walters, PF Jensen, V Larraillet, K Lin, T Patapoff, T Schlothauer, ... Journal of Biological Chemistry 291 (4), 1817-1825, 2016 | 40 | 2016 |
| A two-pronged binding mechanism of IgG to the neonatal Fc receptor controls complex stability and IgG serum half-life PF Jensen, A Schoch, V Larraillet, M Hilger, T Schlothauer, T Emrich, ... Molecular & Cellular Proteomics 16 (3), 451-456, 2017 | 38 | 2017 |
| XGFR*, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic … JM Schanzer, K Wartha, E Moessner, RJ Hosse, S Moser, R Croasdale, ... MAbs 8 (4), 811-827, 2016 | 37 | 2016 |
| CD4-anchoring HIV-1 fusion inhibitor with enhanced potency and in vivo stability C Ji, E Kopetzki, A Jekle, KG Stubenrauch, X Liu, J Zhang, E Rao, ... Journal of biological chemistry 284 (8), 5175-5185, 2009 | 33 | 2009 |
| Functional assessment of antibody oxidation by native mass spectrometry M Haberger, AK Heidenreich, T Schlothauer, M Hook, J Gassner, ... MAbs 7 (5), 891-900, 2015 | 31 | 2015 |
| Quantification of cell surface proteins with bispecific antibodies C Panke, D Weininger, A Haas, F Schelter, T Schlothauer, S Bader, ... Protein Engineering, Design & Selection 26 (10), 645-654, 2013 | 31 | 2013 |
