| Hit and lead criteria in drug discovery for infectious diseases of the developing world K Katsuno, JN Burrows, K Duncan, RH Van Huijsduijnen, T Kaneko, ... Nature Reviews drug discovery 14 (11), 751-758, 2015 | 563 | 2015 |
| New developments in anti-malarial target candidate and product profiles JN Burrows, S Duparc, WE Gutteridge, R Hooft van Huijsduijnen, ... Malaria journal 16, 1-29, 2017 | 504 | 2017 |
| The open access malaria box: a drug discovery catalyst for neglected diseases T Spangenberg, JN Burrows, P Kowalczyk, S McDonald, TNC Wells, ... PloS one 8 (6), e62906, 2013 | 405 | 2013 |
| Designing the next generation of medicines for malaria control and eradication JN Burrows, R Hooft van Huijsduijnen, JJ Möhrle, C Oeuvray, TNC Wells Malaria journal 12, 1-20, 2013 | 346 | 2013 |
| Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination TNC Wells, JN Burrows, JK Baird Trends in parasitology 26 (3), 145-151, 2010 | 342 | 2010 |
| A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria MA Phillips, J Lotharius, K Marsh, J White, A Dayan, KL White, ... Science translational medicine 7 (296), 296ra111-296ra111, 2015 | 331 | 2015 |
| Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors … JM Coteron, M Marco, J Esquivias, X Deng, KL White, J White, M Koltun, ... Journal of medicinal chemistry 54 (15), 5540-5561, 2011 | 325 | 2011 |
| Open source drug discovery with the malaria box compound collection for neglected diseases and beyond WC Van Voorhis, JH Adams, R Adelfio, V Ahyong, MH Akabas, P Alano, ... PLoS pathogens 12 (7), e1005763, 2016 | 298 | 2016 |
| Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ... Science translational medicine 9 (387), eaad9735, 2017 | 251 | 2017 |
| Quinolone-3-diarylethers: a new class of antimalarial drug A Nilsen, AN LaCrue, KL White, IP Forquer, RM Cross, J Marfurt, ... Science translational medicine 5 (177), 177ra37-177ra37, 2013 | 251 | 2013 |
| Nature reviews disease primers MA Phillips, JN Burrows, C Manyando Malaria 3, 17050, 2017 | 217 | 2017 |
| P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action LM Sanz, B Crespo, C De-Cozar, XC Ding, JL Llergo, JN Burrows, ... PloS one 7 (2), e30949, 2012 | 217 | 2012 |
| Fragment screening: an introduction AR Leach, MM Hann, JN Burrows, EJ Griffen Molecular BioSystems 2 (9), 429-446, 2006 | 214 | 2006 |
| The global pipeline of new medicines for the control and elimination of malaria MP Anthony, JN Burrows, S Duparc, J JMoehrle, TNC Wells Malaria journal 11, 1-25, 2012 | 198 | 2012 |
| Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis JS Doggett, A Nilsen, I Forquer, KW Wegmann, L Jones-Brando, ... Proceedings of the National Academy of Sciences 109 (39), 15936-15941, 2012 | 197 | 2012 |
| The state of the art in anti-malarial drug discovery and development J N Burrows, K Chibale, T NC Wells Current topics in medicinal chemistry 11 (10), 1226-1254, 2011 | 194 | 2011 |
| Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial … R Gujjar, F El Mazouni, KL White, J White, S Creason, DM Shackleford, ... Journal of medicinal chemistry 54 (11), 3935-3949, 2011 | 191 | 2011 |
| Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum AB Vaidya, JM Morrisey, Z Zhang, S Das, TM Daly, TD Otto, NJ Spillman, ... Nature communications 5 (1), 5521, 2014 | 152 | 2014 |
| An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes JS Albert, N Blomberg, AL Breeze, AJH Brown, JN Burrows, PD Edwards, ... Current Topics in Medicinal Chemistry 7 (16), 1600-1629, 2007 | 149 | 2007 |
| Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity RM Cross, A Monastyrskyi, TS Mutka, JN Burrows, DE Kyle, R Manetsch Journal of medicinal chemistry 53 (19), 7076-7094, 2010 | 141 | 2010 |
