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Mithun Khattar
Mithun Khattar
Director, Cell Therapies, Obsidian Therapeutics
在 obsidiantx.com 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
“Default” generation of neonatal regulatory T cells
G Wang, Y Miyahara, Z Guo, M Khattar, SM Stepkowski, W Chen
The Journal of Immunology 185 (1), 71-78, 2010
1502010
A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models
ES Lightcap, P Yu, S Grossman, K Song, M Khattar, K Xega, X He, ...
Science translational medicine 13 (611), eaba7791, 2021
652021
Expanding and converting regulatory T cells: a horizon for immunotherapy
M Khattar, W Chen, SM Stepkowski
Archivum immunologiae et therapiae experimentalis 57, 199-204, 2009
492009
IL-2-deprivation and TGF-β are two non-redundant suppressor mechanisms of CD4+ CD25+ regulatory T cell which jointly restrain CD4+ CD25− cell activation
G Wang, M Khattar, Z Guo, Y Miyahara, SP Linkes, Z Sun, X He, ...
Immunology letters 132 (1-2), 61-68, 2010
312010
A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells
Z Guo, M Khattar, PM Schroder, Y Miyahara, G Wang, X He, W Chen, ...
The Journal of Immunology 190 (7), 3153-3162, 2013
302013
Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts
M Khattar, R Deng, BD Kahan, PM Schroder, T Phan, LP Rutzky, ...
Transplantation 95 (7), 919-927, 2013
282013
Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells
Y Miyahara, M Khattar, PM Schroder, B Mierzejewska, R Deng, R Han, ...
American Journal of Transplantation 12 (6), 1409-1418, 2012
252012
Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions
M Khattar, Y Miyahara, PM Schroder, A Xie, W Chen, SM Stepkowski
PLoS One 9 (1), e85882, 2014
202014
TAK-981: A first in class SUMO inhibitor in Phase 1 trials that promotes dendritic cell activation, antigen-presentation, and T cell priming
M Khattar, K Song, S Grossman, K Xega, X He, N Idamakanti, D Huszar
Cancer research 79 (13_Supplement), 3252-3252, 2019
172019
Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection
M Khattar, CE Baum, P Schroder, JD Breidenbach, ST Haller, W Chen, ...
Plos one 14 (11), e0225624, 2019
92019
IL-7, but not thymic stromal lymphopoietin (TSLP), during priming enhances the generation of memory CD4+ T cells
Z Guo, G Wang, Y Miyahara, M Khattar, SP Linkes, C Wang, J Xia, Y Pan, ...
Immunology letters 128 (2), 116-123, 2010
92010
Synergy of an anti-HER2 ADC TAK-522 (XMT-1522) in combination with anti-PD1 monoclonal antibody (mAb) in a syngeneic breast cancer model expressing human HER2
M Khattar, T Traore, K Horton, M Gallery, P Brauer, J Riceberg, N Bodyak, ...
The Journal of Immunology 200 (1_Supplement), 122.29-122.29, 2018
82018
Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice
R Deng, M Khattar, A Xie, PM Schroder, X He, W Chen, SM Stepkowski
Transplantation 97 (12), 1216-1224, 2014
72014
Optimizing the use of regulatory T cells in allotransplantation: recent advances and future perspectives
CE Baum, B Mierzejewska, PM Schroder, M Khattar, S Stepkowski
Expert review of clinical immunology 9 (12), 1303-1314, 2013
72013
Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice
PM Schroder, M Khattar, R Deng, A Xie, W Chen, SM Stepkowski
Plos one 8 (7), e69397, 2013
52013
AGEN1884, an IgG1 anti-CTLA-4 antibody, combines effectively with PD-1 blockade in primary human T cell assays and in a non-human primate pharmacodynamic (PD) model
EE Drouin, D Savitsky, AM Gonzalez, R Gombos, D Chand, J Waight, ...
Cancer Research 77 (13_Supplement), 3654-3654, 2017
42017
PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRβ mAb therapy
PM Schroder, M Khattar, CE Baum, Y Miyahara, W Chen, R Vyas, ...
Diabetologia 58, 1309-1318, 2015
42015
166 Genetically engineered tumor-infiltrating lymphocytes (cytoTIL15) exhibit IL-2-independent persistence and anti-tumor efficacy against melanoma in vivo
R Burga, M Khattar, S Lajoie, K Pedro, C Foley, AV Ocando, J Tremblay, ...
Journal for ImmunoTherapy of Cancer 9 (Suppl 2), 2021
32021
Enhancers of innate and adaptive immunity combine with membrane bound IL15 to increase the efficacy of tumor infiltrating lymphocyte (TIL) therapy for tumors with …
C Passaro, B Koscso, S Smith, V Young, T Ross, B Primack, N Ly, ...
J. Immunother. Cancer https://doi. org/10.1136/jitc-2022-sitc2022 369, 2022
22022
Abstract lb-294: Synergy of an anti-HER2 ADC TAK-522 (XMT-1522) in combination with anti-PD1 monoclonal antibody (MAB) in a syngeneic breast cancer model expressing human HER2
T Traore, M Khattar
Cancer Research 78 (13_Supplement), LB-294-LB-294, 2018
22018
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