Knocking down barriers: advances in siRNA delivery KA Whitehead, R Langer, DG Anderson Nature Reviews Drug Discovery 8 (2), 129-138, 2009 | 3643 | 2009 |
Lipid-like materials for low-dose, in vivo gene silencing KT Love, KP Mahon, CG Levins, KA Whitehead, W Querbes, JR Dorkin, ... Proceedings of the National Academy of Sciences 107 (5), 1864-1869, 2010 | 1089 | 2010 |
mRNA vaccines for infectious diseases: principles, delivery and clinical translation N Chaudhary, D Weissman, KA Whitehead Nature reviews Drug discovery 20 (11), 817-838, 2021 | 825 | 2021 |
Tools for translation: non-viral materials for therapeutic mRNA delivery KA Hajj, KA Whitehead Nature Reviews Materials 2 (10), 1-17, 2017 | 652 | 2017 |
Managing diabetes with nanomedicine: challenges and opportunities O Veiseh, BC Tang, KA Whitehead, DG Anderson, R Langer Nature Reviews Drug Discovery 14 (1), 45-57, 2015 | 600 | 2015 |
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity KA Whitehead, JR Dorkin, AJ Vegas, PH Chang, O Veiseh, J Matthews, ... Nature communications 5 (1), 4277, 2014 | 528 | 2014 |
Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation D Chen, KT Love, Y Chen, AA Eltoukhy, C Kastrup, G Sahay, A Jeon, ... Journal of the American Chemical Society 134 (16), 6948-6951, 2012 | 517 | 2012 |
Materials for oral delivery of proteins and peptides TD Brown, KA Whitehead, S Mitragotri Nature Reviews Materials 5 (2), 127-148, 2020 | 361 | 2020 |
Action and reaction: the biological response to siRNA and its delivery vehicles RL Kanasty, KA Whitehead, AJ Vegas, DG Anderson Molecular Therapy 20 (3), 513-524, 2012 | 323 | 2012 |
Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery DJ Siegwart, KA Whitehead, L Nuhn, G Sahay, H Cheng, S Jiang, M Ma, ... Proceedings of the National Academy of Sciences 108 (32), 12996-13001, 2011 | 267 | 2011 |
Silencing or stimulation? siRNA delivery and the immune system KA Whitehead, JE Dahlman, RS Langer, DG Anderson Annual review of chemical and biomolecular engineering 2 (1), 77-96, 2011 | 258 | 2011 |
Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization RL Ball, P Bajaj, KA Whitehead International journal of nanomedicine, 305-315, 2017 | 233 | 2017 |
Lipid nanoparticle formulations for enhanced co-delivery of siRNA and mRNA RL Ball, KA Hajj, J Vizelman, P Bajaj, KA Whitehead Nano letters 18 (6), 3814-3822, 2018 | 230 | 2018 |
Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability NG Lamson, A Berger, KC Fein, KA Whitehead Nature biomedical engineering 4 (1), 84-96, 2020 | 224 | 2020 |
Aminoalcohol lipidoids and uses thereof KP Mahon, KT Love, CG Levins, KA Whitehead, RS Langer, DG Anderson US Patent 8,450,298, 2013 | 204 | 2013 |
Branched‐tail lipid nanoparticles potently deliver mRNA in vivo due to enhanced ionization at endosomal pH KA Hajj, RL Ball, SB Deluty, SR Singh, D Strelkova, CM Knapp, ... Small 15 (6), 1805097, 2019 | 200 | 2019 |
Oral delivery of macromolecules using intestinal patches: applications for insulin delivery K Whitehead, Z Shen, S Mitragotri Journal of controlled release 98 (1), 37-45, 2004 | 172 | 2004 |
Safe and effective permeation enhancers for oral drug delivery K Whitehead, N Karr, S Mitragotri Pharmaceutical research 25, 1782-1788, 2008 | 164 | 2008 |
Advances in drug delivery BP Timko, K Whitehead, W Gao, DS Kohane, O Farokhzad, D Anderson, ... Annual Review of Materials Research 41 (1), 1-20, 2011 | 155 | 2011 |
Nanoparticulate cellular patches for cell-mediated tumoritropic delivery H Cheng, CJ Kastrup, R Ramanathan, DJ Siegwart, M Ma, SR Bogatyrev, ... ACS nano 4 (2), 625-631, 2010 | 151 | 2010 |