| Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach HO Tawfik, A Petreni, CT Supuran, MH El-Hamamsy European Journal of Medicinal Chemistry 232 (15), 1-20, 2022 | 35 | 2022 |
| Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro and in vivo … AA Al-Karmalawy, MS Nafie, MA Shaldam, AA Elmaaty, SA Antar, ... Journal of Medicinal Chemistry 66 (1), 777-792, 2022 | 29 | 2022 |
| Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors HO Tawfik, TF El-Moselhy, NA Sharafeldin, MH El-Hamamsy Bioorganic & Medicinal Chemistry 27 (23), 1-16, 2019 | 23 | 2019 |
| The plausible mechanisms of tramadol for treatment of COVID-19 NE El-Ashmawy, AHA Lashin, KM Okasha, AMA Kamer, TM Mostafa, ... Medical Hypotheses 146, 110468, 2021 | 21 | 2021 |
| Novel 3-(6-methylpyridin-2-yl) coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity HO Tawfik, MA Shaldam, A Nocentini, R Salem, H Almahli, ... Journal of enzyme inhibition and medicinal chemistry 37 (1), 1043-1052, 2022 | 17 | 2022 |
| Terminators or guardians? design, synthesis, and cytotoxicity profiling of chalcone-sulfonamide hybrids SM Aboukhatwa, PA Sidhom, A Angeli, CT Supuran, HO Tawfik ACS omega 8 (8), 7666-7683, 2023 | 16 | 2023 |
| Dependence on linkers’ flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents HO Tawfik, A Belal, MAS Abourehab, A Angeli, A Bonardi, CT Supuran, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 2765-2785, 2022 | 16 | 2022 |
| Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors MA Shaldam, H Almahli, A Angeli, RM Badi, EF Khaleel, ... Journal of Enzyme Inhibition and Medicinal Chemistry 38 (1), 2203389, 2023 | 15 | 2023 |
| Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors MH El‐Hamamsy, NA Sharafeldin, TF El‐Moselhy, HO Tawfik Archiv der Pharmazie 353 (8), 1-18, 2020 | 15 | 2020 |
| Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics … F Farouk, AA Elmaaty, A Elkamhawy, HO Tawfik, R Alnajjar, ... Journal of Enzyme Inhibition and Medicinal Chemistry 38 (1), 2171029, 2023 | 14 | 2023 |
| New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small … HO Tawfik, AA El-Hamaky, EA El-Bastawissy, KA Shcherbakov, ... Pharmaceuticals 15 (4), 481, 2022 | 14 | 2022 |
| Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and … AA Al-Karmalawy, M Rashed, M Sharaky, HS Abulkhair, MM Hammouda, ... European Journal of Medicinal Chemistry 259, 115661, 2023 | 12 | 2023 |
| Novel 4-(2-arylidenehydrazineyl) thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights HA Elsebaie, EA El-Bastawissy, KM Elberembally, EF Khaleel, RM Badi, ... Bioorganic Chemistry 140, 106799, 2023 | 12 | 2023 |
| Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition SM Aboukhatwa, AO Ibrahim, H Aoyama, AS Al-Behery, MA Shaldam, ... Bioorganic Chemistry 129, 106126, 2022 | 11 | 2022 |
| Synthesis, crystallographic, DNA binding, and molecular docking/dynamic studies of a privileged chalcone-sulfonamide hybrid scaffold as a promising anticancer agent M Shaldam, H Tawfik, H Elmansi, F Belal, K Yamaguchi, M Sugiura, ... Journal of Biomolecular Structure and Dynamics 41 (18), 8876-8890, 2023 | 8 | 2023 |
| Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and … MH Saad, TF El-Moselhy, N S, El-Din, ABM Mehany, A Belal, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 2489-2511, 2022 | 8 | 2022 |
| Development of new thieno [2, 3-d] pyrimidines as dual EGFR and STAT3 inhibitors endowed with anticancer and pro-apoptotic activities HA Elsebaie, TF El-Moselhy, EA El-Bastawissy, KM Elberembally, ... Bioorganic Chemistry 143, 107101, 2024 | 6 | 2024 |
| Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma HO Tawfik, MM Saleh, A Ammara, EF Khaleel, R Badi, YTT Khater, ... Journal of Medicinal Chemistry 67 (2), 1611-1623, 2024 | 6 | 2024 |
| Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo … AA Al-Karmalawy, MHA Mousa, M Sharaky, MAE Mourad, ... Journal of Medicinal Chemistry 67 (1), 492-512, 2023 | 6 | 2023 |
| Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2 HI Ghamry, A Belal, MK El-Ashrey, HO Tawfik, RI Alsantali, AJ Obaidullah, ... Scientific Reports 13 (1), 7357, 2023 | 6 | 2023 |
Moataz Ahmed ShaldamAssistant Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University在 pharm.kfs.edu.eg 的电子邮件经过验证
