Emerging approaches for regulation and control of CAR T cells: a mini review LJB Brandt, MB Barnkob, YS Michaels, J Heiselberg, T Barington Frontiers in Immunology 11, 326, 2020 | 95 | 2020 |
Precise tuning of gene expression levels in mammalian cells YS Michaels, MB Barnkob, H Barbosa, TA Baeumler, MK Thompson, ... Nature communications 10 (1), 818, 2019 | 69 | 2019 |
Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression DJHF Knapp, YS Michaels, M Jamilly, QRV Ferry, H Barbosa, TA Milne, ... Nature communications 10 (1), 1490, 2019 | 46 | 2019 |
DLL4 and VCAM1 enhance the emergence of T cell–competent hematopoietic progenitors from human pluripotent stem cells YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, ... Science Advances 8 (34), eabn5522, 2022 | 31 | 2022 |
FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency IA Rota, AE Handel, S Maio, F Klein, F Dhalla, ME Deadman, S Cheuk, ... Science Advances 7 (49), eabj9247, 2021 | 19 | 2021 |
Multi-objective optimization reveals time-and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development JM Edgar, YS Michaels, PW Zandstra NPJ Regenerative Medicine 7 (1), 11, 2022 | 16 | 2022 |
In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering Q Wu, QRV Ferry, TA Baeumler, YS Michaels, DM Vitsios, O Habib, ... Nature Communications 8 (1), 2109, 2017 | 14 | 2017 |
Interrogation of functional miRNA–target interactions by CRISPR/Cas9 genome engineering YS Michaels, Q Wu, TA Fulga MicroRNA Detection and Target Identification: Methods and Protocols, 79-97, 2017 | 10 | 2017 |
Synthetic gene circuits for cell state detection and protein tuning in human pluripotent stem cells L Prochazka, YS Michaels, C Lau, RD Jones, M Siu, T Yin, D Wu, E Jang, ... Molecular Systems Biology 18 (11), e10886, 2022 | 8 | 2022 |
Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying N Prywes, YS Michaels, A Pal, SS Oh, JW Szostak Chemical Communications 52 (39), 6529-6532, 2016 | 7 | 2016 |
Bioengineering translational models of lymphoid tissues YS Michaels, CF Buchanan, N Gjorevski, A Moisan Nature Reviews Bioengineering 1 (10), 731-748, 2023 | 6 | 2023 |
Engineering T cell development for the next generation of stem cell-derived immunotherapies YS Michaels, LJ Durland, PW Zandstra GEN biotechnology 2 (2), 106-119, 2023 | 6 | 2023 |
Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells MB Barnkob, YS Michaels, V André, PS Macklin, U Gileadi, S Valvo, ... BioRxiv, 849083, 2019 | 2 | 2019 |
Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells MB Barnkob, YS Michaels, V André, PS Macklin, U Gileadi, S Valvo, ... nature communications 15 (1), 3173, 2024 | 1 | 2024 |
Time-and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification YS Michaels, MC Major, B Bonham-Carter, J Zhang, T Heydari, JM Edgar, ... bioRxiv, 2023.10. 06.561277, 2023 | 1 | 2023 |
Interrogation of Functional miRNA-Target Interactions by CRISPR/Cas9 Genome Engineering Q Wu, YS Michaels, TA Fulga MicroRNA Detection and Target Identification: Methods and Protocols, 243-264, 2023 | 1 | 2023 |
Discrete-to-analog signal conversion in human pluripotent stem cells L Prochazka, YS Michaels, C Lau, M Siu, T Yin, D Wu, E Jang, RD Jones, ... bioRxiv, 2021.11. 05.467377, 2021 | 1 | 2021 |
Precise tuning of gene expression output levels in mammalian cells YS Michaels, MB Barnkob, H Barbosa, TA Baeumler, MK Thompson, ... bioRxiv, 352377, 2018 | 1 | 2018 |
3164–IDENTIFICATION OF GENE REGULATORY NETWORKS ESSENTIAL FOR HEMATOPOIETIC PROGENITOR CELL AND T CELL EMERGENCE FROM HUMAN PLURIPOTENT STEM CELL VIA CRISPR SCREENS M Siu, E Flaschner, Y Michaels, P Zandstra Experimental Hematology 137, 104484, 2024 | | 2024 |
A method for producing blood progenitor and progenitor t cells, resulting cells and methods and uses thereof PW Zandstra, YS Michaels US Patent App. 18/561,873, 2024 | | 2024 |