Treatment of a mouse model of ALS by in vivo base editing CKW Lim, M Gapinske, AK Brooks, WS Woods, JE Powell, J Winter, ... Molecular Therapy 28 (4), 1177-1189, 2020 | 170 | 2020 |
Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies CH Lo, CKW Lim, Z Ding, SP Wickramasinghe, AR Braun, KH Ashe, ... Alzheimer's & Dementia 15 (11), 1489-1502, 2019 | 59 | 2019 |
Targeted gene silencing in the nervous system with CRISPR-Cas13 JE Powell, CKW Lim, R Krishnan, TX McCallister, C Saporito-Magriña, ... Science advances 8 (3), eabk2485, 2022 | 57 | 2022 |
Noncompetitive inhibitors of TNFR1 probe conformational activation states CH Lo, TM Schaaf, BD Grant, CKW Lim, P Bawaskar, CC Aldrich, ... Science signaling 12 (592), eaav5637, 2019 | 50 | 2019 |
Discovery of small molecule inhibitors of huntingtin exon 1 aggregation by FRET-based high-throughput screening in living cells CH Lo, NK Pandey, CKW Lim, Z Ding, M Tao, DD Thomas, R Langen, ... ACS Chemical Neuroscience 11 (15), 2286-2295, 2020 | 26 | 2020 |
CRISPR base editing of cis-regulatory elements enables the perturbation of neurodegeneration-linked genes CKW Lim, TX McCallister, C Saporito-Magriña, GD McPheron, R Krishnan, ... Molecular Therapy 30 (12), 3619-3631, 2022 | 13 | 2022 |
Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors CKW Lim, AJ Miskalis, P Perez-Pinera, T Gaj Base Editors: Methods and Protocols, 135-158, 2023 | 2 | 2023 |
Treatment of a Mouse Model of ALS by CRISPR Base Editing CKW Lim, M Gapinske, AK Brooks, WS Woods, JE Powell, AC Zeballos, ... MOLECULAR THERAPY 28 (4), 406-406, 2020 | 2 | 2020 |
A novel small molecule screening platform for disrupting toxic tau oligomers in cells CH Lo, CKW Lim, Z Ding, S Wickramasinghe, AR Braun, E Rhoades, ... bioRxiv, 510412, 2019 | 2 | 2019 |
A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD TX McCallister, CKW Lim, WM Terpstra, S Zhang, JE Powell, T Gaj bioRxiv, 2023 | | 2023 |
CRISPR base editing of cis-regulatory elements enables target gene perturbations CKW Lim, TX McCallister, C Saporito-Magriña, GD McPheron, R Krishnan, ... bioRxiv, 2022.05. 26.493649, 2022 | | 2022 |
Targeted Gene Knockdown in the Brain and Spinal Cord by CRISPR-Cas13 CKW Lim, JE Powell, R Krishnan, TX McCallister, C Saporito-Magrina, ... MOLECULAR THERAPY 30 (4), 300-300, 2022 | | 2022 |
Lowering Huntingtin Gene Expression by Targeted Base Editing of Cis-Regulatory Elements in its Promoter Sequence TX McCallister, CKW Lim, C Saporito-Magrina, R Krishnan, GD McPheron, ... MOLECULAR THERAPY 30 (4), 390-390, 2022 | | 2022 |
Development of Platforms to Target HTT In Vivo Using Base Editing Technologies S Shirguppe, M Gapinske, D Swami, P Acharya, D Anand, D Joulani, ... MOLECULAR THERAPY 30 (4), 298-298, 2022 | | 2022 |
Genome Editing and CRISPR Technology CKW Lim, T Gaj Encyclopedia of Cell Biology: Volume 1-6, Second Edition, 650-656, 2022 | | 2022 |
Manipulation of Tau Oligomerization and Aggregation Characterized by Time-Resolved FRET CH Lo, T Schaaf, B Grant, CKW Lim, D Thomas, J Sachs Biophysical Journal 114 (3), 585a-586a, 2018 | | 2018 |