Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin JD Powers, CC Yuan, KJ McCabe, JD Murray, MC Childers, GV Flint, ... Proceedings of the National Academy of Sciences 116 (23), 11502-11507, 2019 | 41 | 2019 |
Danicamtiv increases myosin recruitment and alters cross-bridge cycling in cardiac muscle KB Kooiker, S Mohran, KL Turner, W Ma, A Martinson, G Flint, L Qi, C Gao, ... Circulation Research 133 (5), 430-443, 2023 | 12 | 2023 |
The biochemically defined super relaxed state of myosin—a paradox S Mohran, K Kooiker, M Mahoney-Schaefer, C Mandrycky, K Kao, AY Tu, ... Journal of Biological Chemistry 300 (1), 2024 | 6 | 2024 |
Epicardially Placed Bioengineered Cardiomyocyte Xenograft in Immune‐Competent Rat Model of Heart Failure IR Chinyere, P Bradley, J Uhlorn, J Eason, S Mohran, GG Repetti, ... Stem cells international 2021 (1), 9935679, 2021 | 5 | 2021 |
Doppler assessment of diastolic function reflect the severity of injury in rats with chronic heart failure P Sanchez, JJ Lancaster, K Weigand, SAEE Mohran, S Goldman, ... Journal of Cardiac Failure 23 (10), 753-761, 2017 | 4 | 2017 |
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration S Lee, AS Vander Roest, CA Blair, K Kao, SB Bremner, MC Childers, ... Proceedings of the National Academy of Sciences 121 (19), e2318413121, 2024 | 2* | 2024 |
Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor K Kooiker, QF Gan, M Yu, N Sa, S Mohran, Y Cheng, G Flint, S Neys, ... Journal of General Physiology 156 (10), e202313503, 2024 | 1 | 2024 |
MYBPC3-c. 772G> A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient-induced stem cell-derived cardiomyocyte model of hypertrophic … S Steczina, S Mohran, L Bailey, T McMillen, KB Kooiker, NB Wood, ... Biophysical Journal 123 (3), 318a-319a, 2024 | 1 | 2024 |
Measuring the Contractile Kinetics of Isolated Myofibrils from Human-Induced Pluripotent Stem Cell Derived Cardiomyocyte (hiPSC-CM) Models of Cardiomyopathy S Mohran, S Steczina, C Mandrycky, K Kao, M Regnier Familial Cardiomyopathies: Methods and Protocols, 213-233, 2023 | 1 | 2023 |
Structure-Function Investigation of the E258K-Mybpc3 Mutation in HCM Patient-Derived Cardiomyocytes S Steczina, JM Pioner, S Mohran, M Langione, G Vitale, B Scellini, ... Biophysical Journal 120 (3), 253a-254a, 2021 | 1 | 2021 |
Cardiac grafts engineered from human induced pluripotent stem cell ventricular pure or heterogeneous cardiomyocytes display synchronous and spontaneous contraction and reduce … JJ Lancaster, J Koevary, IR Chinyere, SAE Mohran, EB Juneman, ... Circulation Research 121 (suppl_1), A344-A344, 2017 | 1 | 2017 |
The modulation of myosin function: How small molecules and sarcomeric mutations impact actomyosin interactions S Mohran | | 2024 |
The effect of small molecule myosin inhibitors on ATP cycling in porcine cardiac muscle using stopped-flow spectroscopy and in vitro motility M Mahoney-Schaefer, KB Kooiker, S Mohran, GV Flint, M Regnier, ... Biophysical Journal 123 (3), 266a-267a, 2024 | | 2024 |
Mechanisms of myosin, myofibril, and cardiomyocyte dysfunction with the MYH7 R403Q mutation in porcine ventricle muscle S Mohran, S Steczina, KB Kooiker, T McMillen, C Mandrycky, MC Childers, ... Biophysical Journal 123 (3), 267a, 2024 | | 2024 |
Decoupling calcium-dependent thin-filament activation from thick-filament activation in porcine myocardium S Mohran, C Mandrycky, A Tu, T McMillen, KB Kooiker, W Qian, TC Irving, ... Biophysical Journal 123 (3), 520a, 2024 | | 2024 |
MYH3 mutations associated with distal arthrogryposis alter the contractility and myosin isoform switching of hiPSC-derived skeletal muscle C Mandrycky, S Mohran, MC Childers, SM Luttrell, E Choi, K Buckingham, ... Biophysical Journal 123 (3), 275a, 2024 | | 2024 |
A molecular-scale investigation of the mechanisms of contractile dysfunction for the hypertrophic cardiomyopathy MYH7 G256E mutation KY Kao, MC Childers, S Mohran, M Regnier Biophysical Journal 123 (3), 267a, 2024 | | 2024 |
2-Deoxy-ATP reduces the cardiac depressive effect of acidosis MA Redd, TS McMillen, MK Woodward, S Mohran, KB Kooiker, GV Flint, ... Biophysical Journal 123 (3), 403a-404a, 2024 | | 2024 |
The effect of small molecule myosin modulators on ATP turnover in pig cardiac HMM using stopped flow spectroscopy KB Kooiker, S Mohran, M Mahoney-Schaefer, J Freeman, MA Geeves, ... Biophysical Journal 122 (3), 121a-122a, 2023 | | 2023 |
The β-myosin G256E mutation impairs relaxation by altering transducer stiffness MC Childers, KY Kao, S Mohran, M Regnier Biophysical Journal 122 (3), 402a, 2023 | | 2023 |