| Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS T Nagata, CA Dwyer, K Yoshida-Tanaka, K Ihara, M Ohyagi, H Kaburagi, ... Nature biotechnology 39 (12), 1529-1536, 2021 | 91 | 2021 |
| Chimeric antisense oligonucleotide conjugated to α-tocopherol T Nishina, J Numata, K Nishina, K Yoshida-Tanaka, K Nitta, W Piao, ... Molecular Therapy-Nucleic Acids 4, 2015 | 67 | 2015 |
| Highly efficient silencing of microRNA by heteroduplex oligonucleotides K Yoshioka, T Kunieda, Y Asami, H Guo, H Miyata, K Yoshida-Tanaka, ... Nucleic acids research 47 (14), 7321-7332, 2019 | 43 | 2019 |
| Stereocontrolled synthesis of Boranophosphate DNA by an Oxazaphospholidine approach and evaluation of its properties RI Hara, T Saito, T Kogure, Y Hamamura, N Uchiyama, Y Nukaga, ... The Journal of Organic Chemistry 84 (12), 7971-7983, 2019 | 21 | 2019 |
| Synthesis and properties of cationic oligopeptides with different side chain lengths that bind to RNA duplexes Y Maeda, R Iwata, T Wada Bioorganic & medicinal chemistry 21 (7), 1717-1723, 2013 | 19 | 2013 |
| Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs RI Hara, Y Hisada, Y Maeda, T Yokota, T Wada Scientific reports 8 (1), 4323, 2018 | 17 | 2018 |
| An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability A Irie, K Sato, RI Hara, T Wada, F Shibasaki Scientific reports 10 (1), 14845, 2020 | 14 | 2020 |
| Synthesis of oligodiaminosaccharides having α-glycoside bonds and their interactions with oligonucleotide duplexes R Iwata, M Sudo, K Nagafuji, T Wada The Journal of Organic Chemistry 76 (15), 5895-5906, 2011 | 14 | 2011 |
| Synthesis of oligodiaminomannoses and analysis of their RNA duplex binding properties and their potential application as siRNA-based drugs R Iwata, A Doi, Y Maeda, T Wada Organic & Biomolecular Chemistry 13 (36), 9504-9515, 2015 | 12 | 2015 |
| Solid-Phase Synthesis of Phosphate/Boranophosphate Chimeric DNAs Using the H-Phosphonate–H-Boranophosphonate Method K Sato, H Imai, T Shuto, RI Hara, T Wada The Journal of Organic Chemistry 84 (23), 15032-15041, 2019 | 11 | 2019 |
| Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cells R Iwata, F Nakayama, S Hirochi, K Sato, W Piao, K Nishina, T Yokota, ... Bioorganic & Medicinal Chemistry Letters 25 (4), 815-819, 2015 | 11 | 2015 |
| Double-stranded RNA-binding artificial cationic oligosaccharides stabilizing siRNAs with a low N/P ratio RI Hara, Y Maeda, T Sakamoto, T Wada Organic & Biomolecular Chemistry 15 (7), 1710-1717, 2017 | 10 | 2017 |
| Solid‐Phase Synthesis of Fluorinated Analogues of Glycosyl 1‐Phosphate Repeating Structures from Leishmania using the Phosphoramidite Method RI Hara, A Yaoita, K Takeda, H Ueki, A Ishii, H Imoto, S Kobayashi, ... ChemistryOpen 7 (6), 439-446, 2018 | 9 | 2018 |
| Synthesis and properties of double-stranded RNA-bindable oligodiaminogalactose derivatives conjugated with vitamin E R Iwata, K Nishina, T Yokota, T Wada Bioorganic & Medicinal Chemistry 22 (4), 1394-1403, 2014 | 9 | 2014 |
| DNA–RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing RI Hara, K Yoshioka, T Yokota Gapmers: Methods and Protocols, 113-119, 2020 | 8 | 2020 |
| Synthesis and properties of 2-deoxy-2-fluoromannosyl phosphate derivatives RI Hara, S Kobayashi, M Noro, K Sato, T Wada Tetrahedron 73 (31), 4560-4565, 2017 | 7 | 2017 |
| Solid-phase stereocontrolled synthesis of oligomeric P-modified glycosyl phosphate derivatives using the oxazaphospholidine method K Sato, T Hagio, M Sano, K Muramoto, A Yaoita, M Noro, RI Hara, T Wada ACS omega 6 (30), 20026-20041, 2021 | 6 | 2021 |
| Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides RI Hara, Y Maeda, H Fujimaki, T Wada Chemical Communications 54 (61), 8526-8529, 2018 | 6* | 2018 |
| Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide RI Hara, T Wada Organic & Biomolecular Chemistry 19 (31), 6865-6870, 2021 | 4 | 2021 |
| Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives RI Hara, R Yoshino, Y Nukaga, Y Maeda, K Sato, T Wada RSC advances 10 (56), 34006-34013, 2020 | 4 | 2020 |
