| Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720 Y Kharel, S Lee, AH Snyder, SL Sheasley-O'Neill, MA Morris, Y Setiady, ... Journal of Biological Chemistry 280 (44), 36865-36872, 2005 | 249 | 2005 |
| Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate Y Kharel, M Raje, M Gao, AM Gellett, JL Tomsig, KR Lynch, WL Santos Biochemical Journal 447 (1), 149-157, 2012 | 107 | 2012 |
| Molecular analysis of cis-prenyl chain elongating enzymes Y Kharel, T Koyama Natural product reports 20 (1), 111-118, 2003 | 100 | 2003 |
| Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells AJ Kennedy, TP Mathews, Y Kharel, SD Field, ML Moyer, JE East, ... Journal of medicinal chemistry 54 (10), 3524-3548, 2011 | 97 | 2011 |
| Asymmetric synthesis of conformationally constrained fingolimod analogues—discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 … R Zhu, AH Snyder, Y Kharel, L Schaffter, Q Sun, PC Kennedy, KR Lynch, ... Journal of medicinal chemistry 50 (25), 6428-6435, 2007 | 93 | 2007 |
| Divergent roles of sphingosine kinases in kidney ischemia–reperfusion injury SK Jo, A Bajwa, H Ye, AL Vergis, AS Awad, Y Kharel, KR Lynch, ... Kidney international 75 (2), 167-175, 2009 | 84 | 2009 |
| Structure− activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of sphK1-and sphK2-selective inhibitors NN Patwardhan, EA Morris, Y Kharel, MR Raje, M Gao, JL Tomsig, ... Journal of medicinal chemistry 58 (4), 1879-1899, 2015 | 78 | 2015 |
| Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate Y Kharel, TP Mathews, AM Gellett, JL Tomsig, PC Kennedy, ML Moyer, ... Biochemical Journal 440 (3), 345-353, 2011 | 78 | 2011 |
| Discovery, biological evaluation, and structure− activity relationship of amidine based sphingosine kinase inhibitors TP Mathews, AJ Kennedy, Y Kharel, PC Kennedy, O Nicoara, M Sunkara, ... Journal of medicinal chemistry 53 (7), 2766-2778, 2010 | 75 | 2010 |
| Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels Y Kharel, EA Morris, MD Congdon, SB Thorpe, JL Tomsig, WL Santos, ... Journal of Pharmacology and Experimental Therapeutics 355 (1), 23-31, 2015 | 73 | 2015 |
| Manipulation of prenyl chain length determination mechanism of cis‐prenyltransferases Y Kharel, S Takahashi, S Yamashita, T Koyama The FEBS journal 273 (3), 647-657, 2006 | 71 | 2006 |
| Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors MR Raje, K Knott, Y Kharel, P Bissel, KR Lynch, WL Santos Bioorganic & medicinal chemistry 20 (1), 183-194, 2012 | 49 | 2012 |
| Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs FW Foss Jr, TP Mathews, Y Kharel, PC Kennedy, AH Snyder, MD Davis, ... Bioorganic & medicinal chemistry 17 (16), 6123-6136, 2009 | 47 | 2009 |
| Identification of significant residues for homoallylic substrate binding of Micrococcus luteus BP 26 undecaprenyl diphosphate synthase Y Kharel, YW Zhang, M Fujihashi, K Miki, T Koyama Journal of Biological Chemistry 276 (30), 28459-28464, 2001 | 45 | 2001 |
| Transforming sphingosine kinase 1 inhibitors into dual and sphingosine kinase 2 selective inhibitors: design, synthesis, and in vivo activity ES Childress, Y Kharel, AM Brown, DR Bevan, KR Lynch, WL Santos Journal of medicinal chemistry 60 (9), 3933-3957, 2017 | 44 | 2017 |
| Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke R Cao, J Li, Y Kharel, C Zhang, E Morris, WL Santos, KR Lynch, Z Zuo, ... Theranostics 8 (22), 6111, 2018 | 34 | 2018 |
| A rapid assay for assessment of sphingosine kinase inhibitors and substrates Y Kharel, TP Mathews, AJ Kennedy, JD Houck, TL Macdonald, KR Lynch Analytical biochemistry 411 (2), 230-235, 2011 | 32 | 2011 |
| Mechanism of sphingosine 1-phosphate clearance from blood Y Kharel, T Huang, A Salamon, TE Harris, WL Santos, KR Lynch Biochemical Journal 477 (5), 925-935, 2020 | 29 | 2020 |
| Structure–activity relationship studies and molecular modeling of naphthalene-based sphingosine kinase 2 inhibitors MD Congdon, Y Kharel, AM Brown, SN Lewis, DR Bevan, KR Lynch, ... ACS Medicinal Chemistry Letters 7 (3), 229-234, 2016 | 28 | 2016 |
| Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney S Tanaka, S Zheng, Y Kharel, RG Fritzemeier, T Huang, D Foster, ... Science translational medicine 14 (658), eabj2681, 2022 | 27 | 2022 |
