Analysis of microRNA turnover in mammalian cells following Dicer1 ablation MP Gantier, CE McCoy, I Rusinova, D Saulep, D Wang, D Xu, AT Irving, ... Nucleic acids research 39 (13), 5692-5703, 2011 | 502 | 2011 |
Lessons from the host defences of bats, a unique viral reservoir AT Irving, M Ahn, G Goh, DE Anderson, LF Wang Nature 589 (7842), 363-370, 2021 | 307 | 2021 |
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host M Ahn, DE Anderson, Q Zhang, CW Tan, BL Lim, K Luko, M Wen, ... Nature microbiology 4 (5), 789-799, 2019 | 298 | 2019 |
The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling AT Irving, H Mimuro, TA Kufer, C Lo, R Wheeler, LJ Turner, BJ Thomas, ... Cell host & microbe 15 (5), 623-635, 2014 | 238 | 2014 |
Animal and translational models of SARS-CoV-2 infection and COVID-19 MD Johansen, A Irving, X Montagutelli, MD Tate, I Rudloff, MF Nold, ... Mucosal immunology 13 (6), 877-891, 2020 | 194 | 2020 |
Unique loss of the PYHIN gene family in bats amongst mammals: implications for inflammasome sensing M Ahn, J Cui, AT Irving, LF Wang Scientific reports 6 (1), 21722, 2016 | 162 | 2016 |
ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton X Yuan, L Yu, J Li, G Xie, T Rong, L Zhang, J Chen, Q Meng, AT Irving, ... Cancer research 73 (12), 3625-3637, 2013 | 143 | 2013 |
Unraveling the zoonotic origin and transmission of SARS-CoV-2 A Banerjee, AC Doxey, K Mossman, AT Irving Trends in ecology & evolution 36 (3), 180-184, 2021 | 99 | 2021 |
Genetic modulation of TLR8 response following bacterial phagocytosis MP Gantier, AT Irving, M Kaparakis‐Liaskos, D Xu, VA Evans, ... Human mutation 31 (9), 1069-1079, 2010 | 93 | 2010 |
Rational design of immunostimulatory siRNAs MP Gantier, S Tong, MA Behlke, AT Irving, M Lappas, UW Nilsson, E Latz, ... Molecular Therapy 18 (4), 785-795, 2010 | 86 | 2010 |
The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF AJ Sadler, BA Suliman, L Yu, X Yuan, D Wang, AT Irving, ST Sarvestani, ... Nature communications 6 (1), 6795, 2015 | 75 | 2015 |
BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs AJ Sadler, FJ Rossello, L Yu, JA Deane, X Yuan, D Wang, AT Irving, ... Proceedings of the National Academy of Sciences 112 (5), 1535-1540, 2015 | 66 | 2015 |
Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats G Goh, M Ahn, F Zhu, LB Lee, D Luo, AT Irving, LF Wang Proceedings of the National Academy of Sciences 117 (46), 28939-28949, 2020 | 64 | 2020 |
Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense AT Irving, D Wang, O Vasilevski, O Latchoumanin, N Kozer, AHA Clayton, ... Immunity 36 (5), 795-806, 2012 | 56 | 2012 |
High basal heat-shock protein expression in bats confers resistance to cellular heat/oxidative stress Y g Ten Chionh, J Cui, J Koh, IH Mendenhall, JHJ Ng, D Low, K Itahana, ... Cell Stress and Chaperones 24 (4), 835-849, 2019 | 54 | 2019 |
Interferon regulatory factors IRF1 and IRF7 directly regulate gene expression in bats in response to viral infection AT Irving, Q Zhang, PS Kong, K Luko, P Rozario, M Wen, F Zhu, P Zhou, ... Cell reports 33 (5), 2020 | 53 | 2020 |
Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection MJ Christie, AT Irving, SC Forster, BJ Marsland, PM Hansbro, PJ Hertzog, ... Science immunology 6 (63), eabd0205, 2021 | 52 | 2021 |
Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto JM Martínez Gómez, P Periasamy, CA Dutertre, AT Irving, JHJ Ng, ... Scientific reports 6 (1), 37796, 2016 | 52 | 2016 |
Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses A Banerjee, N El-Sayes, P Budylowski, RA Jacob, D Richard, H Maan, ... IScience 24 (5), 2021 | 49 | 2021 |
Helicobacter pylori VacA suppresses Lactobacillus acidophilus-induced interferon beta signaling in macrophages via alterations in the endocytic pathway G Weiss, S Forster, A Irving, M Tate, RL Ferrero, P Hertzog, H Frøkiær, ... MBio 4 (3), 10.1128/mbio. 00609-12, 2013 | 46 | 2013 |