The interplay between DNA and histone methylation: molecular mechanisms and disease implications Y Li, X Chen, C Lu EMBO reports 22 (5), e51803, 2021 | 128 | 2021 |
SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair M Tang, Z Li, C Zhang, X Lu, B Tu, Z Cao, Y Li, Y Chen, L Jiang, H Wang, ... Science advances 5 (3), eaav1118, 2019 | 111 | 2019 |
Advances in cellular characterization of the sirtuin isoform, SIRT7 D Wu, Y Li, KS Zhu, H Wang, WG Zhu Frontiers in endocrinology 9, 652, 2018 | 82 | 2018 |
PCAF/GCN5-mediated acetylation of RPA1 promotes nucleotide excision repair M Zhao, R Geng, X Guo, R Yuan, X Zhou, Y Zhong, Y Huo, M Zhou, ... Cell reports 20 (9), 1997-2009, 2017 | 81 | 2017 |
Destabilization of linker histone H1. 2 is essential for ATM activation and DNA damage repair Z Li, Y Li, M Tang, B Peng, X Lu, Q Yang, Q Zhu, T Hou, M Li, C Liu, ... Cell research 28 (7), 756-770, 2018 | 75 | 2018 |
Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer M Tang, X Lu, C Zhang, C Du, L Cao, T Hou, Z Li, B Tu, Z Cao, Y Li, ... Theranostics 7 (5), 1346, 2017 | 71 | 2017 |
SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair T Hou, Z Cao, J Zhang, M Tang, Y Tian, Y Li, X Lu, Y Chen, H Wang, ... Nucleic Acids Research 48 (6), 2982-3000, 2020 | 67 | 2020 |
Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage Y Li, Z Li, L Dong, M Tang, P Zhang, C Zhang, Z Cao, Q Zhu, Y Chen, ... Nucleic acids research 46 (15), 7716-7730, 2018 | 62 | 2018 |
Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis L Jiang, J Xiong, J Zhan, F Yuan, M Tang, C Zhang, Z Cao, Y Chen, X Lu, ... Journal of Biological Chemistry 292 (32), 13296-13311, 2017 | 61 | 2017 |
Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma N Farhangdoost, C Horth, B Hu, E Bareke, X Chen, Y Li, M Coradin, ... Cell reports 34 (8), 2021 | 55 | 2021 |
CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis C Liu, Q Yang, Q Zhu, X Lu, M Li, T Hou, Z Li, M Tang, Y Li, H Wang, ... Theranostics 10 (4), 1758, 2020 | 39 | 2020 |
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas Y Li, EM Goldberg, X Chen, X Xu, JT McGuire, G Leuzzi, D Karagiannis, ... Molecular cell 82 (20), 3901-3918. e7, 2022 | 33 | 2022 |
SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle YF Lu, XP Xu, XP Lu, Q Zhu, G Liu, YT Bao, H Wen, YL Li, W Gu, WG Zhu Oncogene 39 (24), 4650-4665, 2020 | 33 | 2020 |
CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection FK Geis, Y Sabo, X Chen, Y Li, C Lu, SP Goff Proceedings of the National Academy of Sciences 119 (4), e2116735119, 2022 | 22 | 2022 |
PIK3CA and p53 Mutations Promote 4NQO-Initated Head and Neck Tumor Progression and Metastasis in Mice D García-Carracedo, Y Cai, W Qiu, K Saeki, RA Friedman, A Lee, Y Li, ... Molecular Cancer Research 18 (6), 822-834, 2020 | 16 | 2020 |
Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements Z Li, S Duan, X Hua, X Xu, Y Li, D Menolfi, H Zhou, C Lu, S Zha, SP Goff, ... Nature 623 (7987), 643-651, 2023 | 15 | 2023 |
Molecular mechanisms of epigenetic regulators as activatable targets in cancer theranostics Y Li, Z Li, WG Zhu Current Medicinal Chemistry 26 (8), 1328-1350, 2019 | 15 | 2019 |
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion G Leuzzi, A Vasciaveo, A Taglialatela, X Chen, TM Firestone, ... Cell 187 (4), 861-881. e32, 2024 | 12 | 2024 |
Regulation of DNA damage-induced ATM activation by histone modifications Z Li, Y Chen, M Tang, Y Li, WG Zhu Genome Instability & Disease 1, 20-33, 2020 | 9 | 2020 |
Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma X Chen, Y Li, F Zhu, X Xu, B Estrella, MA Pazos, JT McGuire, ... Nature Communications 14 (1), 4259, 2023 | 6 | 2023 |