Entanglement of GSK-3β, β-catenin and TGF-β1 signaling network to regulate myocardial fibrosis Y Guo, M Gupte, P Umbarkar, AP Singh, JY Sui, T Force, H Lal Journal of molecular and cellular cardiology 110, 109-120, 2017 | 148 | 2017 |
Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy P Umbarkar, S Singh, S Arkat, SL Bodhankar, S Lohidasan, SL Sitasawad Free Radical Biology and Medicine 87, 263-273, 2015 | 86 | 2015 |
Ponatinib-induced cardiotoxicity: delineating the signalling mechanisms and potential rescue strategies AP Singh, MS Glennon, P Umbarkar, M Gupte, CL Galindo, Q Zhang, ... Cardiovascular research 115 (5), 966-977, 2019 | 64 | 2019 |
Mitochondrial peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in diabetic cardiomyopathy S Arkat, P Umbarkar, S Singh, SL Sitasawad Free Radical Biology and Medicine 97, 489-500, 2016 | 52 | 2016 |
Cardiomyocyte SMAD4-dependent TGF-β signaling is essential to maintain adult heart homeostasis P Umbarkar, AP Singh, M Gupte, VK Verma, CL Galindo, Y Guo, Q Zhang, ... JACC: Basic to Translational Science 4 (1), 41-53, 2019 | 48 | 2019 |
Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling After Myocardial Infarction JC Snider, LA Riley, NT Mallory, MR Bersi, P Umbarkar, R Gautam, ... Circulation 143 (13), 1317-1330, 2021 | 47 | 2021 |
Cardiotoxicity of the BCR-ABL1 tyrosine kinase inhibitors: Emphasis on ponatinib AP Singh, P Umbarkar, S Tousif, H Lal International journal of cardiology 316, 214-221, 2020 | 43 | 2020 |
Mechanisms of fibroblast activation and myocardial fibrosis: lessons learned from FB-specific conditional mouse models P Umbarkar, S Ejantkar, S Tousif, H Lal Cells 10 (9), 2412, 2021 | 36 | 2021 |
Inhibition of GSK-3 to induce cardiomyocyte proliferation: a recipe for in situ cardiac regeneration AP Singh, P Umbarkar, Y Guo, T Force, M Gupte, H Lal Cardiovascular research 115 (1), 20-30, 2019 | 36 | 2019 |
A pharmacovigilance study of hydroxychloroquine cardiac safety profile: potential implication in COVID-19 mitigation AP Singh, S Tousif, P Umbarkar, H Lal Journal of clinical medicine 9 (6), 1867, 2020 | 27 | 2020 |
Fibroblast GSK-3α promotes fibrosis via RAF-MEK-ERK pathway in the injured heart P Umbarkar, S Tousif, AP Singh, JC Anderson, Q Zhang, MD Tallquist, ... Circulation research 131 (7), 620-636, 2022 | 26 | 2022 |
Cardiomyocyte-specific deletion of GSK-3β leads to cardiac dysfunction in a diet induced obesity model M Gupte, S Tumuluru, JY Sui, AP Singh, P Umbarkar, SS Parikh, F Ahmad, ... International journal of cardiology 259, 145-152, 2018 | 25 | 2018 |
Ponatinib drives cardiotoxicity by S100A8/A9-NLRP3-IL-1β mediated inflammation S Tousif, AP Singh, P Umbarkar, C Galindo, N Wheeler, A Toro Cora, ... Circulation research 132 (3), 267-289, 2023 | 16 | 2023 |
Repurposing Nintedanib for pathological cardiac remodeling and dysfunction P Umbarkar, AP Singh, S Tousif, Q Zhang, P Sethu, H Lal Pharmacological research 169, 105605, 2021 | 15 | 2021 |
Deletion of cardiomyocyte glycogen synthase kinase-3 beta (GSK-3β) improves systemic glucose tolerance with maintained heart function in established obesity M Gupte, P Umbarkar, AP Singh, Q Zhang, S Tousif, H Lal Cells 9 (5), 1120, 2020 | 10 | 2020 |
Isoform-specific role of GSK-3 in high fat diet induced obesity and glucose intolerance M Gupte, S Tousif, JJ Lemon, A Toro Cora, P Umbarkar, H Lal Cells 11 (3), 559, 2022 | 8 | 2022 |
Mechanistic Insights of Empagliflozin-Mediated Cardiac Benefits: Nearing the Starting Line: Editorial to:“Empagliflozin Improves Left Ventricular Diastolic Dysfunction in a … M Gupte, P Umbarkar, H Lal Cardiovascular drugs and therapy 31 (3), 229-232, 2017 | 8 | 2017 |
GSK-3 at the heart of cardiometabolic diseases: Isoform-specific targeting is critical to therapeutic benefit P Umbarkar, SYR Ramirez, AT Cora, S Tousif, H Lal Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1869 (6), 166724, 2023 | 7 | 2023 |
The BDNF rs6265 polymorphism is a modifier of cardiomyocyte contractility and dilated cardiomyopathy FJ Raucci Jr, AP Singh, J Soslow, LW Markham, L Zhong, W Aljafar, ... International Journal of Molecular Sciences 21 (20), 7466, 2020 | 6 | 2020 |
Sustained Increases in Cardiomyocyte Protein O‐Linked β‐N‐Acetylglucosamine Levels Lead to Cardiac Hypertrophy and Reduced Mitochondrial Function … CM Ha, S Bakshi, MK Brahma, LA Potter, SF Chang, Z Sun, ... Journal of the American Heart Association 12 (19), e029898, 2023 | 5 | 2023 |