Impaired cargo clearance in the retinal pigment epithelium (RPE) underlies irreversible blinding diseases E Keeling, AJ Lotery, DA Tumbarello, JA Ratnayaka Cells 7 (2), 16, 2018 | 72 | 2018 |
The complexities underlying age-related macular degeneration: could amyloid beta play an important role? SA Lynn, E Keeling, R Munday, G Gabha, H Griffiths, AJ Lotery, ... Neural regeneration research 12 (4), 538-548, 2017 | 47 | 2017 |
Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE SA Lynn, G Ward, E Keeling, JA Scott, AJ Cree, DA Johnston, A Page, ... Tissue and Cell 49 (4), 447-460, 2017 | 29 | 2017 |
The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2) G Taylor-Walker, SA Lynn, E Keeling, R Munday, DA Johnston, A Page, ... Experimental eye research 153, 110-121, 2016 | 21 | 2016 |
Oxidative stress and dysfunctional intracellular traffic linked to an unhealthy diet results in impaired cargo transport in the retinal pigment epithelium (RPE) E Keeling, DS Chatelet, DA Johnston, A Page, DA Tumbarello, AJ Lotery, ... Molecular nutrition & food research 63 (15), 1800951, 2019 | 19 | 2019 |
A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy P Ibbett, SV Goverdhan, E Pipi, JK Chouhan, E Keeling, EM Angus, ... Scientific Reports 9 (1), 7475, 2019 | 19 | 2019 |
3D-reconstructed retinal pigment epithelial cells provide insights into the anatomy of the outer retina E Keeling, DS Chatelet, NYT Tan, F Khan, R Richards, T Thisainathan, ... International journal of molecular sciences 21 (21), 8408, 2020 | 18 | 2020 |
A convenient protocol for establishing a human cell culture model of the outer retina. SA Lynn, E Keeling, JM Dewing, DA Johnston, A Page, AJ Cree, ... F1000Research 7, 2018 | 18 | 2018 |
Oligomeric Aβ1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function SA Lynn, DA Johnston, JA Scott, R Munday, RS Desai, E Keeling, ... Cells 10 (2), 413, 2021 | 15 | 2021 |
A High Fat “Western‐style” Diet Induces AMD‐Like Features in Wildtype Mice E Keeling, SA Lynn, YM Koh, JA Scott, A Kendall, M Gatherer, A Page, ... Molecular Nutrition & Food Research 66 (11), 2100823, 2022 | 11 | 2022 |
An in-vitro cell model of intracellular protein aggregation provides insights into RPE stress associated with retinopathy E Keeling, AJ Culling, DA Johnston, DS Chatelet, A Page, DA Tumbarello, ... International journal of molecular sciences 21 (18), 6647, 2020 | 8 | 2020 |
Impaired cargo clearance in the retinal pigment epithelium (RPE) underlies irreversible blinding diseases. Cells 7 E Keeling, AJ Lotery, DA Tumbarello, JA Ratnayaka E16, 2018 | 5 | 2018 |
Serial block face scanning electron microscopy reveals novel organizational details of the retinal pigment epithelium JA Ratnayaka, E Keeling Neural Regeneration Research 17 (3), 569-571, 2022 | 3 | 2022 |
Human equivalent doses of l-DOPA rescues retinal morphology and visual function in a murine model of albinism A Sanchez-Bretano, E Keeling, JA Scott, SA Lynn, SP Soundara-Pandi, ... Scientific Reports 13 (1), 17173, 2023 | 1 | 2023 |
Study of Intracellular Cargo Trafficking and Co-localization in the Phagosome and Autophagy-Lysosomal Pathways of Retinal Pigment Epithelium (RPE) Cells JA Ratnayaka, E Keeling, DS Chatelet Imaging and Tracking Stem Cells: Methods and Protocols, 167-182, 2020 | 1 | 2020 |
Lysosomal impairment in the Retinal Pigment Epithelium (RPE)-a pathway of damage in the ageing retina E Keeling, DA Johnston, DS Chatelet, D Tumbarello, A Lotery, ... Investigative Ophthalmology & Visual Science 59 (9), 4487-4487, 2018 | 1 | 2018 |
Eyetracking-enhanced VEP for nystagmus P Carter, F Shawkat, J Self, H Lee, E Keeling, M Dunn Investigative Ophthalmology & Visual Science 64 (8), 43-43, 2023 | | 2023 |
Intraluminal acidity plays a key role in the function of lysosomes in RPE cells RD Miller, SA Lynn, E Keeling, C Ellis, D Chatelet, DA Johnston, ... Investigative Ophthalmology & Visual Science 64 (8), 3891-3891, 2023 | | 2023 |
Use of a handheld electrophysiology device (RETeval, LKC) to identify visual pathway decussation defects E Keeling, P Carter, F Shawkat, H Lee, J Self Investigative Ophthalmology & Visual Science 64 (8), 5325-5325, 2023 | | 2023 |
Dataset in support of the publication'Human equivalent doses of L-DOPA rescues retinal morphology and visual function in a murine model of albinism' E Keeling, H Lee University of Southampton, 2023 | | 2023 |