β-Lactamases and β-Lactamase Inhibitors in the 21st Century CL Tooke, P Hinchliffe, EC Bragginton, CK Colenso, VHA Hirvonen, ... Journal of molecular biology 431 (18), 3472-3500, 2019 | 894 | 2019 |
Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes P Hinchliffe, MM González, MF Mojica, JM González, V Castillo, C Saiz, ... Proceedings of the National Academy of Sciences 113 (26), E3745-E3754, 2016 | 154 | 2016 |
Insights into the mechanistic basis of plasmid-mediated colistin resistance from crystal structures of the catalytic domain of MCR-1 P Hinchliffe, QE Yang, E Portal, T Young, H Li, CL Tooke, MJ Carvalho, ... Scientific reports 7 (1), 39392, 2017 | 148 | 2017 |
Molecular basis of class A β-lactamase inhibition by relebactam CL Tooke, P Hinchliffe, PA Lang, AJ Mulholland, J Brem, CJ Schofield, ... Antimicrobial agents and chemotherapy 63 (10), 10.1128/aac. 00564-19, 2019 | 63 | 2019 |
Exploitation of antibiotic resistance as a novel drug target: Development of a β-lactamase-activated antibacterial prodrug LE Evans, A Krishna, Y Ma, TE Webb, DC Marshall, CL Tooke, J Spencer, ... Journal of medicinal chemistry 62 (9), 4411-4425, 2019 | 62 | 2019 |
Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics I Galdadas, S Qu, ASF Oliveira, E Olehnovics, AR Mack, MF Mojica, ... Elife 10, e66567, 2021 | 50 | 2021 |
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography A Butryn, PS Simon, P Aller, P Hinchliffe, RN Massad, G Leen, CL Tooke, ... Nature communications 12 (1), 4461, 2021 | 46 | 2021 |
A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation CT Lohans, E van Groesen, K Kumar, CL Tooke, J Spencer, RS Paton, ... Angewandte Chemie 130 (5), 1296-1299, 2018 | 43 | 2018 |
Mechanistic insights into β-lactamase-catalysed carbapenem degradation through product characterisation CT Lohans, EI Freeman, E Groesen, CL Tooke, P Hinchliffe, J Spencer, ... Scientific reports 9 (1), 13608, 2019 | 41 | 2019 |
Profiling interactions of vaborbactam with metallo-β-lactamases GW Langley, R Cain, JM Tyrrell, P Hinchliffe, K Calvopiña, CL Tooke, ... Bioorganic & Medicinal Chemistry Letters 29 (15), 1981-1984, 2019 | 41 | 2019 |
Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance CL Tooke, P Hinchliffe, RA Bonomo, CJ Schofield, AJ Mulholland, ... Journal of Biological Chemistry 296, 2021 | 36 | 2021 |
Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants CT Lohans, HTH Chan, TR Malla, K Kumar, JJAG Kamps, DJB McArdle, ... Angewandte Chemie International Edition 58 (7), 1990-1994, 2019 | 33 | 2019 |
Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition CL Tooke, P Hinchliffe, A Krajnc, AJ Mulholland, J Brem, CJ Schofield, ... RSC medicinal chemistry 11 (4), 491-496, 2020 | 28 | 2020 |
Faropenem reacts with serine and metallo-β-lactamases to give multiple products A Lucic, P Hinchliffe, TR Malla, CL Tooke, J Brem, K Calvopiña, ... European journal of medicinal chemistry 215, 113257, 2021 | 16 | 2021 |
Tautomer-specific deacylation and Ω-loop flexibility explain the carbapenem-hydrolyzing broad-spectrum activity of the KPC-2 β-lactamase CL Tooke, P Hinchliffe, M Beer, K Zinovjev, CK Colenso, CJ Schofield, ... Journal of the American Chemical Society 145 (13), 7166-7180, 2023 | 10 | 2023 |
Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2 A Lucic, TR Malla, K Calvopiña, CL Tooke, J Brem, MA McDonough, ... Antibiotics 11 (3), 396, 2022 | 9 | 2022 |
Penicillanic acid sulfones inactivate the extended-spectrum β-lactamase CTX-M-15 through formation of a serine-lysine cross-link: An alternative mechanism of β-lactamase inhibition P Hinchliffe, CL Tooke, CR Bethel, B Wang, C Arthur, KJ Heesom, ... Mbio 13 (3), e01793-21, 2022 | 4 | 2022 |
Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics P Dulyayangkul, T Beavis, WWY Lee, R Ardagh, F Edwards, F Hamilton, ... PLoS Pathogens 20 (6), e1012235, 2024 | | 2024 |
Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme M Beer, ASF Oliveira, CL Tooke, P Hinchliffe, ATY Li, B Balega, J Spencer, ... bioRxiv, 2024.04. 29.591639, 2024 | | 2024 |
Substrate and inhibitor interactions of class A β-lactamases CL Tooke University of Bristol, 2020 | | 2020 |