| Non-canonical Hedgehog/AMPK-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth D D’Amico, L Antonucci, L Di Magno, S Coni, G Sdruscia, A Macone, ... Developmental cell 35 (1), 21-35, 2015 | 87 | 2015 |
| The coactivator CRTC1 promotes cell proliferation and transformation via AP-1 G Canettieri, S Coni, M Della Guardia, V Nocerino, L Antonucci, ... Proceedings of the National Academy of Sciences 106 (5), 1445-1450, 2009 | 80 | 2009 |
| Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy S Coni, L Antonucci, D D'Amico, L Di Magno, P Infante, E De Smaele, ... PLoS One 8 (6), e65718, 2013 | 79 | 2013 |
| Digging a hole under Hedgehog: downstream inhibition as an emerging anticancer strategy L Di Magno, S Coni, L Di Marcotullio, G Canettieri Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1856 (1), 62-72, 2015 | 76 | 2015 |
| Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma S Coni, AB Mancuso, L Di Magno, G Sdruscia, S Manni, SM Serrao, ... Scientific reports 7 (1), 44079, 2017 | 68 | 2017 |
| Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype P Infante, R Alfonsi, C Ingallina, D Quaglio, F Ghirga, I D'acquarica, ... Cell death & disease 7 (9), e2376-e2376, 2016 | 65 | 2016 |
| Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation S Coni, SM Serrao, ZN Yurtsever, L Di Magno, R Bordone, C Bertani, ... Cell death & disease 11 (12), 1045, 2020 | 57 | 2020 |
| Phenformin inhibits hedgehog-dependent tumor growth through a complex I-independent redox/corepressor module L Di Magno, S Manni, F Di Pastena, S Coni, A Macone, S Cairoli, ... Cell reports 30 (6), 1735-1752. e7, 2020 | 55 | 2020 |
| Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth L Di Magno, D Manzi, D D’Amico, S Coni, A Macone, P Infante, ... Cell Cycle 13 (21), 3404-3413, 2014 | 55 | 2014 |
| The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint L Di Magno, A Basile, S Coni, S Manni, G Sdruscia, D D'Amico, ... Oncotarget 7 (8), 9538, 2016 | 50 | 2016 |
| ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP F Bufalieri, P Infante, F Bernardi, M Caimano, P Romania, M Moretti, ... Nature communications 10 (1), 3304, 2019 | 41 | 2019 |
| Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation L Antonucci, L Di Magno, D D’Amico, S Manni, SM Serrao, F Di Pastena, ... International journal of oncology 54 (2), 505-514, 2018 | 33 | 2018 |
| The mechanism of action of biguanides: New answers to a complex question L Di Magno, F Di Pastena, R Bordone, S Coni, G Canettieri Cancers 14 (13), 3220, 2022 | 28 | 2022 |
| KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2 E Spiombi, A Angrisani, S Fonte, G De Feudis, F Fabretti, D Cucchi, ... Oncogenesis 8 (11), 64, 2019 | 23 | 2019 |
| CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc L Antonucci, D D'Amico, L Di Magno, S Coni, L Di Marcotullio, B Cardinali, ... Cell Cycle 13 (3), 434-439, 2014 | 20 | 2014 |
| Polyamine metabolism as a therapeutic target in Hedgehog-driven basal cell carcinoma and medulloblastoma S Coni, L Di Magno, SM Serrao, Y Kanamori, E Agostinelli, G Canettieri Cells 8 (2), 150, 2019 | 19 | 2019 |
| Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response MV Giuli, G Diluvio, E Giuliani, G Franciosa, L Di Magno, MG Pignataro, ... Oncogenesis 9 (10), 93, 2020 | 18 | 2020 |
| Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents A Coluccia, G La Regina, V Naccarato, M Nalli, V Orlando, S Biagioni, ... ACS Medicinal Chemistry Letters 10 (4), 499-503, 2019 | 13 | 2019 |
| Enzymatic spermine metabolites induce apoptosis associated with increase of p53, caspase-3 and miR-34a in both neuroblastoma cells, SJNKP and the N-Myc-amplified form IMR5 Y Kanamori, A Finotti, L Di Magno, G Canettieri, T Tahara, F Timeus, ... Cells 10 (8), 1950, 2021 | 12 | 2021 |
| Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation S Coni, R Bordone, DM Ivy, ZN Yurtsever, L Di Magno, R D'Amico, ... Cancer Letters 559, 216120, 2023 | 11 | 2023 |
