Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G GBE Stewart-Jones, C Soto, T Lemmin, GY Chuang, A Druz, R Kong, ... Cell 165 (4), 813-826, 2016 | 419 | 2016 |
Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein AJ Behrens, S Vasiljevic, LK Pritchard, DJ Harvey, RS Andev, SA Krumm, ... Cell reports 14 (11), 2695-2706, 2016 | 271 | 2016 |
Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo M Medina-Ramírez, F Garces, A Escolano, P Skog, SW de Taeye, ... Journal of Experimental Medicine 214 (9), 2573-2590, 2017 | 162 | 2017 |
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle PJM Brouwer, A Antanasijevic, Z Berndsen, A Yasmeen, B Fiala, TPL Bijl, ... Nature Communications 10 (1), 4272, 2019 | 157 | 2019 |
Improving the immunogenicity of native-like HIV-1 envelope trimers by hyperstabilization AT de la Pena, JP Julien, SW de Taeye, F Garces, M Guttman, ... Cell reports 20 (8), 1805-1817, 2017 | 150 | 2017 |
Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies LK Pritchard, DIR Spencer, L Royle, C Bonomelli, GE Seabright, ... Nature communications 6 (1), 7479, 2015 | 143 | 2015 |
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence K Sliepen, BW Han, I Bontjer, P Mooij, F Garces, AJ Behrens, ... Nature communications 10 (1), 2355, 2019 | 130 | 2019 |
Structural principles controlling HIV envelope glycosylation AJ Behrens, M Crispin Current opinion in structural biology 44, 125-133, 2017 | 99 | 2017 |
Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion S Halldorsson, AJ Behrens, K Harlos, JT Huiskonen, RM Elliott, M Crispin, ... Proceedings of the National Academy of Sciences 113 (26), 7154-7159, 2016 | 98 | 2016 |
Type IV pilus assembly in Pseudomonas aeruginosa over a broad range of cyclic di-GMP concentrations R Jain, AJ Behrens, V Kaever, BI Kazmierczak Journal of bacteriology 194 (16), 4285-4294, 2012 | 90 | 2012 |
Molecular architecture of the cleavage-dependent mannose patch on a soluble HIV-1 envelope glycoprotein trimer AJ Behrens, DJ Harvey, E Milne, A Cupo, A Kumar, N Zitzmann, ... Journal of virology 91 (2), 10.1128/jvi. 01894-16, 2017 | 85 | 2017 |
cGMP production and analysis of BG505 SOSIP. 664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vaccine candidate AK Dey, A Cupo, G Ozorowski, VK Sharma, AJ Behrens, EP Go, TJ Ketas, ... Biotechnology and bioengineering 115 (4), 885-899, 2018 | 75 | 2018 |
Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1 AJ Behrens, WB Struwe, M Crispin Expert review of proteomics 14 (10), 881-890, 2017 | 57 | 2017 |
Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer A Sarkar, S Bale, AJ Behrens, S Kumar, SK Sharma, N de Val, J Pallesen, ... Nature communications 9 (1), 1956, 2018 | 51 | 2018 |
Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions GE Seabright, CA Cottrell, MJ van Gils, A D'addabbo, DJ Harvey, ... Structure 28 (8), 897-909. e6, 2020 | 46 | 2020 |
Global N-glycan site occupancy of HIV-1 gp120 by metabolic engineering and high-resolution intact mass spectrometry WB Struwe, A Stuckmann, AJ Behrens, K Pagel, M Crispin ACS chemical biology 12 (2), 357-361, 2017 | 38 | 2017 |
Structure-guided redesign improves NFL HIV Env trimer integrity and identifies an inter-protomer disulfide permitting post-expression cleavage L Yang, SK Sharma, C Cottrell, J Guenaga, K Tran, R Wilson, AJ Behrens, ... Frontiers in immunology 9, 1631, 2018 | 35 | 2018 |
Cleavage-independent HIV-1 trimers from CHO cell lines elicit robust autologous tier 2 neutralizing antibodies S Bale, A Martiné, R Wilson, AJ Behrens, V Le Fourn, N De Val, ... Frontiers in Immunology 9, 1116, 2018 | 32 | 2018 |
Integrity of glycosylation processing of a glycan-depleted trimeric HIV-1 immunogen targeting key B-cell lineages AJ Behrens, A Kumar, M Medina-Ramirez, A Cupo, K Marshall, ... Journal of proteome research 17 (3), 987-999, 2018 | 23 | 2018 |
Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers A Schorcht, TLGM van den Kerkhof, CA Cottrell, JD Allen, JL Torres, ... Journal of virology 94 (24), 10.1128/jvi. 01214-20, 2020 | 18 | 2020 |