| The coming of age of engineered multivalent antibodies N Nunez-Prado, M Compte, S Harwood, A Alvarez-Mendez, S Lykkemark, ... Drug discovery today 20 (5), 588-594, 2015 | 156 | 2015 |
| A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity M Compte, SL Harwood, IG Muñoz, R Navarro, M Zonca, G Perez-Chacon, ... Nature communications 9 (1), 4809, 2018 | 129 | 2018 |
| ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy SL Harwood, A Alvarez-Cienfuegos, N Nuñez-Prado, M Compte, ... Oncoimmunology 7 (1), e1377874, 2018 | 77 | 2018 |
| Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains A Alvarez-Cienfuegos, N Nuñez-Prado, M Compte, AM Cuesta, ... Scientific reports 6 (1), 28643, 2016 | 41 | 2016 |
| Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer A Tapia-Galisteo, I Sanchez Rodriguez, O Aguilar-Sopeña, SL Harwood, ... Oncoimmunology 11 (1), 2034355, 2022 | 35 | 2022 |
| Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies K Mølgaard, SL Harwood, M Compte, N Merino, J Bonet, ... Cancer Immunology, Immunotherapy 67 (8), 1251-1260, 2018 | 25 | 2018 |
| Efficacy and toxicity management of CAR-T-cell immunotherapy: a matter of responsiveness control or tumour-specificity? V Alonso-Camino, SL Harwood, A Alvarez-Mendez, L Alvarez-Vallina Biochemical Society Transactions 44 (2), 406-411, 2016 | 25 | 2016 |
| Structural investigations of human A2M identify a hollow native conformation that underlies its distinctive protease-trapping mechanism SL Harwood, J Lyngsø, A Zarantonello, K Kjøge, PK Nielsen, ... Molecular & Cellular Proteomics 20, 2021 | 22 | 2021 |
| An Fc-free EGFR-specific 4-1BB-agonistic trimerbody displays broad antitumor activity in humanized murine cancer models without toxicity M Compte, SL Harwood, A Erce-Llamazares, A Tapia-Galisteo, E Romero, ... Clinical Cancer Research 27 (11), 3167-3177, 2021 | 21 | 2021 |
| Carcinoembryonic antigen (CEA)-specific 4-1BB-costimulation induced by CEA-targeted 4-1BB-agonistic trimerbodies K Mikkelsen, SL Harwood, M Compte, N Merino, K Mølgaard, ... Frontiers in immunology 10, 1791, 2019 | 21 | 2019 |
| Overcoming CAR-mediated CD19 downmodulation and leukemia relapse with T lymphocytes secreting anti-CD19 T-cell Engagers B Blanco, Á Ramírez-Fernández, C Bueno, L Argemí-Muntadas, ... Cancer immunology research 10 (4), 498-511, 2022 | 16 | 2022 |
| Balanced secretion of anti-CEA× anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity K Mølgaard, M Compte, N Nuñez-Prado, SL Harwood, L Sanz, ... Gene Therapy 24 (4), 208-214, 2017 | 14 | 2017 |
| A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response L Rubio-Pérez, R Lázaro-Gorines, SL Harwood, M Compte, R Navarro, ... Oncoimmunology 12 (1), 2205336, 2023 | 10 | 2023 |
| Development of selective protease inhibitors via engineering of the bait region of human α2-macroglobulin SL Harwood, NS Nielsen, K Diep, KT Jensen, PK Nielsen, K Yamamoto, ... Journal of Biological Chemistry 297 (1), 2021 | 10 | 2021 |
| Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity O Hangiu, M Compte, A Dinesen, R Navarro, A Tapia-Galisteo, ... Iscience 25 (9), 2022 | 9 | 2022 |
| Case report: an EGFR-targeted 4-1BB-agonistic trimerbody does not induce hepatotoxicity in transgenic mice with liver expression of human EGFR M Compte, SL Harwood, J Martínez-Torrecuadrada, G Perez-Chacon, ... Frontiers in Immunology 11, 614363, 2021 | 9 | 2021 |
| Substituting the thiol ester of human A2M or C3 with a disulfide produces native proteins with altered proteolysis-induced conformational changes SL Harwood, NS Nielsen, H Pedersen, K Kjøge, PK Nielsen, ... Biochemistry 59 (51), 4799-4809, 2020 | 9 | 2020 |
| Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family NS Nielsen, A Zarantonello, SL Harwood, KT Jensen, K Kjøge, ... Nature Communications 13 (1), 3033, 2022 | 7 | 2022 |
| α2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester SL Harwood, NS Nielsen, KT Jensen, PK Nielsen, IB Thøgersen, ... Journal of Biological Chemistry 295 (49), 16732-16742, 2020 | 7 | 2020 |
| Construction of novel bispecific single-domain antibodies (BiSdAbs) with potent antiangiogenic activities X Liu, T Sun, Q Ge, J Zhu Pharmaceutical Fronts 2 (01), e64-e76, 2020 | 6 | 2020 |
Jan. J. EnghildProfessor, Department of molecular biology and genetics, Aarhus University, Denmark在 mbg.au.dk 的电子邮件经过验证
Jan. J. EnghildProfessor, Department of molecular biology and genetics, Aarhus University, Denmark在 mbg.au.dk 的电子邮件经过验证