Robust deep learning–based protein sequence design using ProteinMPNN J Dauparas, I Anishchenko, N Bennett, H Bai, RJ Ragotte, LF Milles, ... Science 378 (6615), 49-56, 2022 | 680 | 2022 |
Atomistic insight into lipid translocation by a TMEM16 scramblase NP Bethel, M Grabe Proceedings of the National Academy of Sciences 113 (49), 14049-14054, 2016 | 103 | 2016 |
The sixth transmembrane segment is a major gating component of the TMEM16A calcium-activated chloride channel CJ Peters, JM Gilchrist, J Tien, NP Bethel, L Qi, T Chen, L Wang, YN Jan, ... Neuron 97 (5), 1063-1077. e4, 2018 | 82 | 2018 |
Computational design of mechanically coupled axle-rotor protein assemblies A Courbet, J Hansen, Y Hsia, N Bethel, YJ Park, C Xu, A Moyer, ... Science 376 (6591), 383-390, 2022 | 49 | 2022 |
Continuum descriptions of membranes and their interaction with proteins: towards chemically accurate models D Argudo, NP Bethel, FV Marcoline, M Grabe Biochimica et Biophysica Acta (BBA)-Biomembranes 1858 (7), 1619-1634, 2016 | 45 | 2016 |
New continuum approaches for determining protein-induced membrane deformations D Argudo, NP Bethel, FV Marcoline, CW Wolgemuth, M Grabe Biophysical journal 112 (10), 2159-2172, 2017 | 41 | 2017 |
Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates CJ Guerriero, KR Reutter, AA Augustine, GM Preston, KF Weiberth, ... Molecular biology of the cell 28 (15), 2076-2090, 2017 | 37 | 2017 |
Membrane protein properties revealed through data-rich electrostatics calculations FV Marcoline, N Bethel, CJ Guerriero, JL Brodsky, M Grabe Structure 23 (8), 1526-1537, 2015 | 36 | 2015 |
Chemically induced vesiculation as a platform for studying TMEM16F activity TW Han, W Ye, NP Bethel, M Zubia, A Kim, KH Li, AL Burlingame, ... Proceedings of the National Academy of Sciences 116 (4), 1309-1318, 2019 | 31 | 2019 |
Dynamic hydraulic fluid stimulation regulated intramedullary pressure M Hu, F Serra-Hsu, N Bethel, L Lin, S Ferreri, J Cheng, YX Qin Bone 57 (1), 137-141, 2013 | 19 | 2013 |
A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel D Argudo, S Capponi, NP Bethel, M Grabe Journal of General Physiology 151 (3), 316-327, 2019 | 17 | 2019 |
Interrelation between external oscillatory muscle coupling amplitude and in vivo intramedullary pressure related bone adaptation M Hu, J Cheng, N Bethel, F Serra-Hsu, S Ferreri, L Lin, YX Qin Bone 66, 178-181, 2014 | 14 | 2014 |
Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells MT Veling, DT Nguyen, NN Thadani, ME Oster, NJ Rollins, KP Brock, ... ACS synthetic biology 11 (3), 1292-1302, 2022 | 13 | 2022 |
Precisely patterned nanofibres made from extendable protein multiplexes NP Bethel, AJ Borst, F Parmeggiani, MJ Bick, TJ Brunette, H Nguyen, ... Nature Chemistry 15 (12), 1664-1671, 2023 | 9 | 2023 |
Blueprinting extendable nanomaterials with standardized protein blocks TF Huddy, Y Hsia, RD Kibler, J Xu, N Bethel, D Nagarajan, R Redler, ... Nature 627 (8005), 898-904, 2024 | 7 | 2024 |
Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies NI Edman, A Phal, RL Redler, T Schlichthaerle, SR Srivatsan, DD Ehnes, ... Cell 187 (14), 3726-3740. e43, 2024 | 4 | 2024 |
De novo design of pH-responsive self-assembling helical protein filaments H Shen, EM Lynch, S Akkineni, JL Watson, J Decarreau, NP Bethel, ... Nature Nanotechnology, 1-6, 2024 | 3 | 2024 |
Computational design of nanoscale rotational mechanics in de novo protein assemblies A Courbet, J Hansen, Y Hsia, N Bethel, YJ Park, C Xu, A Moyer, ... bioRxiv, 2021.11. 11.468255, 2021 | 3 | 2021 |
Blueprinting expandable nanomaterials with standardized protein building blocks TF Huddy, Y Hsia, RD Kibler, J Xu, N Bethel, D Nagarajan, R Redler, ... bioRxiv, 2023.06. 09.544258, 2023 | 1 | 2023 |
Local structural flexibility drives oligomorphism in computationally designed protein assemblies A Khmelinskaia, NP Bethel, F Fatehi, A Antanasijevic, AJ Borst, SH Lai, ... bioRxiv, 2023.10. 18.562842, 2023 | 1 | 2023 |