| A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity M Jinek, K Chylinski, I Fonfara, M Hauer, JA Doudna, E Charpentier science 337 (6096), 816-821, 2012 | 20169 | 2012 |
| The new frontier of genome engineering with CRISPR-Cas9 JA Doudna, E Charpentier Science 346 (6213), 1258096, 2014 | 7759 | 2014 |
| CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III E Deltcheva, K Chylinski, CM Sharma, K Gonzales, Y Chao, ZA Pirzada, ... Nature 471 (7340), 602-607, 2011 | 4033 | 2011 |
| Evolution and classification of the CRISPR–Cas systems KS Makarova, DH Haft, R Barrangou, SJJ Brouns, E Charpentier, ... Nature Reviews Microbiology 9 (6), 467-477, 2011 | 3474 | 2011 |
| An updated evolutionary classification of CRISPR–Cas systems KS Makarova, YI Wolf, OS Alkhnbashi, F Costa, SA Shah, SJ Saunders, ... Nature reviews microbiology 13 (11), 722-736, 2015 | 3016 | 2015 |
| Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants KS Makarova, YI Wolf, J Iranzo, SA Shmakov, OS Alkhnbashi, SJJ Brouns, ... Nature Reviews Microbiology 18 (2), 67-83, 2020 | 2077 | 2020 |
| Structures of Cas9 endonucleases reveal RNA-mediated conformational activation M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, ... Science 343 (6176), 1247997, 2014 | 1596 | 2014 |
| The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA I Fonfara, H Richter, M Bratovič, A Le Rhun, E Charpentier Nature 532 (7600), 517-521, 2016 | 1068 | 2016 |
| The biology of CRISPR-Cas: backward and forward F Hille, H Richter, SP Wong, M Bratovič, S Ressel, E Charpentier Cell 172 (6), 1239-1259, 2018 | 1026 | 2018 |
| Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription JA Doudna, M Jinek, E Charpentier, K Chylinski US Patent 10,266,850, 2019 | 952 | 2019 |
| Classification and evolution of type II CRISPR-Cas systems K Chylinski, KS Makarova, E Charpentier, EV Koonin Nucleic acids research 42 (10), 6091-6105, 2014 | 701 | 2014 |
| The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems K Chylinski, A Le Rhun, E Charpentier RNA biology 10 (5), 726-737, 2013 | 618 | 2013 |
| CRISPR-Cas: biology, mechanisms and relevance F Hille, E Charpentier Philosophical transactions of the royal society B: biological sciences 371 …, 2016 | 568 | 2016 |
| Adopt a moratorium on heritable genome editing ES Lander, F Baylis, F Zhang, E Charpentier, P Berg, C Bourgain, ... Nature 567 (7747), 165-168, 2019 | 553 | 2019 |
| Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems I Fonfara, A Le Rhun, K Chylinski, KS Makarova, AL Lecrivain, J Bzdrenga, ... Nucleic acids research 42 (4), 2577-2590, 2014 | 530 | 2014 |
| Antibiotic Resistance in Listeriaspp E Charpentier, P Courvalin Antimicrobial agents and chemotherapy 43 (9), 2103-2108, 1999 | 516 | 1999 |
| Novel cassette-based shuttle vector system for gram-positive bacteria E Charpentier, AI Anton, P Barry, B Alfonso, Y Fang, RP Novick Applied and environmental microbiology 70 (10), 6076-6085, 2004 | 499 | 2004 |
| Emergence of vancomycin tolerance in Streptococcus pneumoniae R Novak, B Henriques, E Charpentier, S Normark, E Tuomanen Nature 399 (6736), 590-593, 1999 | 496 | 1999 |
| Rewriting a genome E Charpentier, JA Doudna Nature 495 (7439), 50-51, 2013 | 376 | 2013 |
| Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity E Charpentier, H Richter, J van der Oost, MF White FEMS microbiology reviews 39 (3), 428-441, 2015 | 358 | 2015 |
