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Parker W de Waal
Parker W de Waal
在 DEShawResearch.com 的电子邮件经过验证
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Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Y Kang, XE Zhou, X Gao, Y He, W Liu, A Ishchenko, A Barty, TA White, ...
Nature 523 (7562), 561, 2015
8342015
Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors
XE Zhou, Y He, PW de Waal, X Gao, Y Kang, N Van Eps, Y Yin, K Pal, ...
Cell 170 (3), 457-469. e13, 2017
4032017
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
Y Kang, O Kuybeda, PW de Waal, S Mukherjee, N Van Eps, P Dutka, ...
Nature, 2018
2582018
Structure and dynamics of the active human parathyroid hormone receptor-1
LH Zhao, S Ma, I Sutkeviciute, DD Shen, XE Zhou, PW de Waal, CY Li, ...
Science 364 (6436), 148-153, 2019
2002019
Structural basis of AMPK regulation by adenine nucleotides and glycogen
X Li, L Wang, XE Zhou, J Ke, PW de Waal, X Gu, MHE Tan, D Wang, ...
Cell research 25 (1), 50, 2015
1902015
A complex structure of arrestin-2 bound to a G protein-coupled receptor
W Yin, Z Li, M Jin, YL Yin, PW De Waal, K Pal, Y Yin, X Gao, Y He, J Gao, ...
Cell research 29 (12), 971-983, 2019
1892019
Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3
LH Zhao, XE Zhou, W Yi, Z Wu, Y Liu, Y Kang, L Hou, PW de Waal, S Li, ...
Cell research 25 (11), 1219, 2015
1762015
Crystal structure of the Frizzled 4 receptor in a ligand-free state.
S Yang, Y Wu, TH Xu, PW de Waal, Y He, M Pu, Y Chen, ZJ DeBruine, ...
Nature, 2018
1092018
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
Y Zhuang, H Liu, X Edward Zhou, R Kumar Verma, PW de Waal, W Jang, ...
Nature communications 11 (1), 885, 2020
942020
Crystal structure of the human 5-HT 1B serotonin receptor bound to an inverse agonist
W Yin, XE Zhou, D Yang, PW de Waal, M Wang, A Dai, X Cai, CY Huang, ...
Cell discovery 4 (1), 12, 2018
802018
Molecular basis for hormone recognition and activation of corticotropin-releasing factor receptors
S Ma, Q Shen, LH Zhao, C Mao, XE Zhou, DD Shen, PW de Waal, P Bi, ...
Molecular cell 77 (3), 669-680. e4, 2020
702020
X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex
XE Zhou, X Gao, A Barty, Y Kang, Y He, W Liu, A Ishchenko, TA White, ...
Scientific data 3 (1), 1-13, 2016
622016
The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer
P Liu, M Jia, XE Zhou, PW de Waal, BM Dickson, B Liu, L Hou, Y Yin, ...
Acta Pharmacologica Sinica, 2016
562016
Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing
X Gu, Y Yan, SJ Novick, A Kovach, D Goswami, J Ke, MHE Tan, L Wang, ...
Journal of Biological Chemistry 292 (30), 12653-12666, 2017
552017
Molecular mechanisms of fentanyl mediated β-arrestin biased signaling
PW de Waal, J Shi, E You, X Wang, K Melcher, Y Jiang, HE Xu, ...
PLOS Computational Biology 16 (4), e1007394, 2020
472020
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and …
LK Golani, A Wallace-Povirk, SM Deis, J Wong, J Ke, X Gu, S Raghavan, ...
Journal of medicinal chemistry 59 (17), 7856-7876, 2016
442016
Structural mechanism of a drug-binding process involving a large conformational change of the protein target
P Ayaz, A Lyczek, YT Paung, VR Mingione, RE Iacob, PW de Waal, ...
Nature communications 14 (1), 1885, 2023
342023
Molecular dynamics of CYP2D6 polymorphisms in the absence and presence of a mechanism-based inactivator reveals changes in local flexibility and dominant substrate access channels
PW de Waal, KF Sunden, LL Furge
PLoS One 9 (10), e108607, 2014
272014
Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class BG protein-coupled receptors
Y Yin, PW de Waal, Y He, LH Zhao, D Yang, X Cai, Y Jiang, K Melcher, ...
Journal of Biological Chemistry, jbc. M117. 782987, 2017
252017
Development of “plug and play” fiducial marks for structural studies of GPCR signaling complexes by single-particle cryo-EM
P Dutka, S Mukherjee, X Gao, Y Kang, PW de Waal, L Wang, Y Zhuang, ...
Structure 27 (12), 1862-1874. e7, 2019
192019
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