| The medicinal chemist's toolbox for late stage functionalization of drug-like molecules T Cernak, KD Dykstra, S Tyagarajan, P Vachal, SW Krska Chemical Society Reviews 45 (3), 546-576, 2016 | 1439 | 2016 |
| Structure-based analysis and optimization of a highly enantioselective catalyst for the Strecker reaction P Vachal, EN Jacobsen Journal of the American Chemical Society 124 (34), 10012-10014, 2002 | 791 | 2002 |
| A general catalyst for the asymmetric Strecker reaction MS Sigman, P Vachal, EN Jacobsen Angewandte Chemie 112 (7), 1336-1338, 2000 | 683 | 2000 |
| Nanomole-scale high-throughput chemistry for the synthesis of complex molecules A Buitrago Santanilla, EL Regalado, T Pereira, M Shevlin, K Bateman, ... Science 347 (6217), 49-53, 2015 | 550 | 2015 |
| Enantioselective catalytic addition of HCN to ketoimines. Catalytic synthesis of quaternary amino acids P Vachal, EN Jacobsen Organic Letters 2 (6), 867-870, 2000 | 490 | 2000 |
| Late‐stage functionalization of biologically active heterocycles through photoredox catalysis DA DiRocco, K Dykstra, S Krska, P Vachal, DV Conway, M Tudge Angewandte Chemie International Edition 53 (19), 4802-4806, 2014 | 472 | 2014 |
| A general small-scale reactor to enable standardization and acceleration of photocatalytic reactions CC Le, MK Wismer, ZC Shi, R Zhang, DV Conway, G Li, P Vachal, ... ACS central science 3 (6), 647-653, 2017 | 215 | 2017 |
| Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods PS Kutchukian, JF Dropinski, KD Dykstra, B Li, DA DiRocco, ... Chemical science 7 (4), 2604-2613, 2016 | 191 | 2016 |
| Practical synthesis of a soluble schiff base catalyst for the asymmetric strecker reaction JT Su, P Vachal, EN Jacobsen Advanced Synthesis & Catalysis 343 (2), 197-200, 2001 | 116 | 2001 |
| Chemoselective peptide modification via photocatalytic tryptophan β-position conjugation Y Yu, LK Zhang, AV Buevich, G Li, H Tang, P Vachal, SL Colletti, ZC Shi Journal of the American Chemical Society 140 (22), 6797-6800, 2018 | 115 | 2018 |
| Microscale high-throughput experimentation as an enabling technology in drug discovery: Application in the discovery of (Piperidinyl) pyridinyl-1 H-benzimidazole diacylglycerol … T Cernak, NJ Gesmundo, K Dykstra, Y Yu, Z Wu, ZC Shi, P Vachal, ... Journal of Medicinal Chemistry 60 (9), 3594-3605, 2017 | 84 | 2017 |
| Profiling and Application of Photoredox C(sp3)–C(sp2) Cross-Coupling in Medicinal Chemistry R Zhang, G Li, M Wismer, P Vachal, SL Colletti, ZC Shi ACS Medicinal Chemistry Letters 9 (7), 773-777, 2018 | 77 | 2018 |
| 1, 3, 8-Triazaspiro [4.5] decane-2, 4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1–3 (HIF PHD1–3) for the treatment of anemia P Vachal, S Miao, JM Pierce, D Guiadeen, VJ Colandrea, MJ Wyvratt, ... Journal of medicinal chemistry 55 (7), 2945-2959, 2012 | 77 | 2012 |
| General facile synthesis of 2, 5-diarylheteropentalenes P Vachal, LM Toth Tetrahedron letters 45 (38), 7157-7161, 2004 | 75 | 2004 |
| Synthesis and study of alendronate derivatives as potential prodrugs of alendronate sodium for the treatment of low bone density and osteoporosis P Vachal, JJ Hale, Z Lu, EC Streckfuss, SG Mills, M MacCoss, DH Yin, ... Journal of medicinal chemistry 49 (11), 3060-3063, 2006 | 72 | 2006 |
| Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench‐Stable Organozinc Reagents TJ Greshock, KP Moore, RT McClain, A Bellomo, CK Chung, SD Dreher, ... Angewandte Chemie 128 (44), 13918-13922, 2016 | 60 | 2016 |
| Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor P Vachal, LM Toth, JJ Hale, L Yan, SG Mills, GL Chrebet, CA Koehane, ... Bioorganic & medicinal chemistry letters 16 (14), 3684-3687, 2006 | 54 | 2006 |
| (3, 4-disubstituted) propanoic carboxylates as S1P (Edg) receptor agonists VJ Colandrea, GA Doherty, JJ Hale, P Huo, IE Legiec, L Toth, P Vachal, ... US Patent 7,605,171, 2009 | 51 | 2009 |
| A new approach to the synthesis of benzofuro[3,2‐b]quinolines, benzothieno[3,2‐b]quinolines and indolo[3,2‐b]quinolines S Rádl, P Konvička, P Váchal Journal of Heterocyclic Chemistry 37 (4), 855-862, 2000 | 51 | 2000 |
| High-throughput purification platform in support of drug discovery M Liu, K Chen, D Christian, T Fatima, N Pissarnitski, E Streckfuss, ... ACS Combinatorial Science 14 (1), 51-59, 2012 | 46 | 2012 |
