Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation X Zhang, K Zhou, R Wang, J Cui, SA Lipton, FF Liao, H Xu, Y Zhang Journal of Biological Chemistry 282 (15), 10873-10880, 2007 | 477 | 2007 |
The γ-secretase complex: from structure to function X Zhang, Y Li, H Xu, Y Zhang Frontiers in cellular neuroscience 8, 427, 2014 | 206 | 2014 |
Trafficking regulation of proteins in Alzheimer’s disease S Jiang, Y Li, X Zhang, G Bu, H Xu, Y Zhang Molecular neurodegeneration 9, 1-13, 2014 | 180 | 2014 |
Transcriptional Regulation of APH-1A and Increased g-Secretase Cleavage of APP and Notch by HIF-1 and Hypoxia R Wang, Y Zhang, X Zhang, R Liu, X Zhang, S Hong, K Xia, J Xia, ... FASEB Journal-Federation of American Societies for Experimental Biology 20 …, 2006 | 123 | 2006 |
The retromer complex and sorting nexins in neurodegenerative diseases H Zhang, T Huang, Y Hong, W Yang, X Zhang, H Luo, H Xu, X Wang Frontiers in aging neuroscience 10, 79, 2018 | 89 | 2018 |
Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration H Zhang, Y Zhang, Y Chen, X Huang, F Zhou, W Wang, B Xian, X Zhang, ... Journal of Neuroscience 32 (44), 15565-15576, 2012 | 72 | 2012 |
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing Y Zhao, Y Wang, J Yang, X Wang, Y Zhao, X Zhang, Y Zhang Molecular neurodegeneration 7, 1-10, 2012 | 65 | 2012 |
A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II S Zhao, Z Li, M Zhang, L Zhang, H Zheng, J Ning, Y Wang, F Wang, ... Experimental & molecular medicine 51 (7), 1-11, 2019 | 51 | 2019 |
Insights into the role of CSF1R in the central nervous system and neurological disorders B Hu, S Duan, Z Wang, X Li, Y Zhou, X Zhang, YW Zhang, H Xu, H Zheng Frontiers in Aging Neuroscience 13, 789834, 2021 | 43 | 2021 |
Transcriptional regulation of PEN-2, a key component of the γ-secretase complex, by CREB R Wang, Y Zhang, P Sun, R Liu, X Zhang, X Zhang, K Xia, J Xia, H Xu, ... Molecular and Cellular Biology, 2006 | 42 | 2006 |
SNX27 deletion causes hydrocephalus by impairing ependymal cell differentiation and ciliogenesis X Wang, Y Zhou, J Wang, IC Tseng, T Huang, Y Zhao, Q Zheng, Y Gao, ... Journal of Neuroscience 36 (50), 12586-12597, 2016 | 39 | 2016 |
Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities X Ye, W Tian, G Wang, X Zhang, M Zhou, D Zeng, X Liu, X Yao, Y Zhang, ... Journal of agricultural and food chemistry 68 (14), 4196-4204, 2020 | 34 | 2020 |
Role of Rab GTPases in Alzheimer’s disease X Zhang, TY Huang, J Yancey, H Luo, Y Zhang ACS chemical neuroscience 10 (2), 828-838, 2018 | 31 | 2018 |
CutA divalent cation tolerance homolog (Escherichia coli)(CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-site APP cleaving protein 1 … Y Zhao, Y Wang, J Hu, X Zhang, Y Zhang Journal of Biological Chemistry 287 (14), 11141-11150, 2012 | 31 | 2012 |
Microglial Tmem59 deficiency impairs phagocytosis of synapse and leads to autism-like behaviors in mice J Meng, L Han, N Zheng, T Wang, H Xu, Y Jiang, Z Wang, Z Liu, Q Zheng, ... Journal of Neuroscience 42 (25), 4958-4979, 2022 | 29 | 2022 |
USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation Q Zheng, B Song, G Li, F Cai, M Wu, Y Zhao, LL Jiang, T Guo, M Shen, ... The Journal of Clinical Investigation 132 (5), 2022 | 28 | 2022 |
β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function Y Gao, Y Hong, L Huang, S Zheng, H Zhang, S Wang, Y Yao, Y Zhao, ... Cell 186 (5), 1026-1038. e20, 2023 | 27 | 2023 |
TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities Z Liu, J Ning, X Zheng, J Meng, L Han, H Zheng, L Zhong, XF Chen, ... Cell Death & Disease 11 (8), 678, 2020 | 27 | 2020 |
β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice Y Zhao, Q Zheng, Y Hong, Y Gao, J Hu, M Lang, H Zhang, Y Zhou, H Luo, ... Nature neuroscience 26 (7), 1170-1184, 2023 | 25 | 2023 |
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability F Zeng, X Ma, L Zhu, Q Xu, Y Zeng, Y Gao, G Li, T Guo, H Zhang, X Tang, ... PLoS Biology 17 (12), e3000525, 2019 | 25 | 2019 |