| Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation L Ma, MA Seager, M Wittmann, M Jacobson, D Bickel, M Burno, K Jones, ... Proceedings of the National Academy of Sciences 106 (37), 15950-15955, 2009 | 366* | 2009 |
| Oscillatory brain states and learning: Impact of hippocampal theta-contingent training MA Seager, LD Johnson, ES Chabot, Y Asaka, SD Berry Proceedings of the National Academy of Sciences 99 (3), 1616-1620, 2002 | 271 | 2002 |
| Inhibition of calcineurin-mediated endocytosis and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid β oligomer-induced synaptic disruption WQ Zhao, F Santini, R Breese, D Ross, XD Zhang, DJ Stone, M Ferrer, ... Journal of Biological Chemistry 285 (10), 7619-7632, 2010 | 235 | 2010 |
| Hippocampal theta oscillations and classical conditioning SD Berry, MA Seager Neurobiology of Learning and Memory 76 (3), 298-313, 2001 | 88 | 2001 |
| Quinolizidinone Carboxylic Acids as CNS Penetrant, Selective M1 Allosteric Muscarinic Receptor Modulators SD Kuduk, RK Chang, CN Di Marco, WJ Ray, L Ma, M Wittmann, ... ACS medicinal chemistry letters 1 (6), 263-267, 2010 | 72 | 2010 |
| Discovery of a Selective Allosteric M1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold SD Kuduk, RK Chang, CN Di Marco, DR Pitts, TJ Greshock, L Ma, ... Journal of medicinal chemistry 54 (13), 4773-4780, 2011 | 68 | 2011 |
| Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators FV Yang, WD Shipe, JL Bunda, MB Nolt, DD Wisnoski, Z Zhao, JC Barrow, ... Bioorganic & medicinal chemistry letters 20 (2), 531-536, 2010 | 61 | 2010 |
| Chronic coadministration of olanzapine and fluoxetine activates locus coeruleus neurons in rats: implications for bipolar disorder MA Seager, VN Barth, LA Phebus, K Rasmussen Psychopharmacology 181 (1), 126-133, 2005 | 59 | 2005 |
| Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity MA Seager, KD Huff, VN Barth, LA Phebus, K Rasmussen Biological psychiatry 55 (11), 1103-1109, 2004 | 57 | 2004 |
| Nonpharmacological amelioration of age-related learning deficits: The impact of hippocampal θ-triggered training Y Asaka, KN Mauldin, AL Griffin, MA Seager, E Shurell, SD Berry Proceedings of the National Academy of Sciences 102 (37), 13284-13288, 2005 | 54 | 2005 |
| The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats K Rasmussen, H Martin, JE Berger, MA Seager Neuropharmacology 48 (2), 173-180, 2005 | 49 | 2005 |
| Scopolamine disruption of behavioral and hippocampal responses in appetitive trace classical conditioning MA Seager, Y Asaka, SD Berry Behavioural brain research 100 (1-2), 143-151, 1999 | 46 | 1999 |
| Medial septal microinfusion of scopolamine disrupts hippocampal activity and trace jaw movement conditioning. Y Asaka, MA Seager, AL Griffin, SD Berry Behavioral neuroscience 114 (6), 1068, 2000 | 44 | 2000 |
| N-heterocyclic derived M1 positive allosteric modulators SD Kuduk, CN Di Marco, V Cofre, DR Pitts, WJ Ray, L Ma, M Wittmann, ... Bioorganic & medicinal chemistry letters 20 (4), 1334-1337, 2010 | 37 | 2010 |
| Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response: Generality and nature of the phenomenon. DL Buck, MA Seager, BG Schreurs Behavioral Neuroscience 115 (5), 1039, 2001 | 35 | 2001 |
| MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate DC Beshore, C N. Di Marco, RK Chang, TJ Greshock, L Ma, M Wittmann, ... ACS medicinal chemistry letters 9 (7), 652-656, 2018 | 29 | 2018 |
| Evaluation of 5-HT7 receptor antagonism for the treatment of anxiety, depression, and schizophrenia through the use of receptor-deficient mice OM Balcer, MA Seager, SD Gleason, X Li, K Rasmussen, JK Maxwell, ... Behavioural brain research 360, 270-278, 2019 | 28 | 2019 |
| Identification of Amides as Carboxylic Acid Surrogates for Quinolizidinone-Based M1 Positive Allosteric Modulators SD Kuduk, RK Chang, TJ Greshock, WJ Ray, L Ma, M Wittmann, ... ACS medicinal chemistry letters 3 (12), 1070-1074, 2012 | 28 | 2012 |
| Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding SD Kuduk, CN Di Marco, V Cofre, DR Pitts, WJ Ray, L Ma, M Wittmann, ... Bioorganic & medicinal chemistry letters 20 (2), 657-661, 2010 | 28 | 2010 |
| Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series SD Kuduk, RK Chang, CN Di Marco, WJ Ray, L Ma, M Wittmann, ... Bioorganic & medicinal chemistry letters 21 (6), 1710-1715, 2011 | 27 | 2011 |
