Peptidomimetic Polo‐Box‐Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor M Baxter, D Chapagai, S Craig, C Hurtado, J Varghese, E Nurmemmedov, ... ChemMedChem 15 (12), 1058-1066, 2020 | 15 | 2020 |
Biotic and abiotic stress signaling mediated by salicylic acid D Kumar, D Chapagai, P Dean, M Davenport Elucidation of Abiotic Stress Signaling in Plants: Functional Genomics …, 2015 | 15 | 2015 |
Nonpeptidic, polo-box domain-targeted inhibitors of plk1 block kinase activity, induce its degradation and target-resistant cells D Chapagai, G Ramamoorthy, J Varghese, E Nurmemmedov, C McInnes, ... Journal of medicinal chemistry 64 (14), 9916-9925, 2021 | 14 | 2021 |
Hormone signaling: current perspectives on the roles of salicylic acid and its derivatives in plants D Kumar, I Haq, D Chapagai, D Tripathi, D Donald, M Hossain, S Devaiah The Formation, Structure and Activity of Phytochemicals, 115-136, 2015 | 14 | 2015 |
Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE SN Craig, M Baxter, D Chapagai, JM Stafford, E Nurmemmedov, ... European journal of medicinal chemistry 227, 113926, 2022 | 11 | 2022 |
Structural Basis for Variations in Polo-like Kinase 1 Conformation and Intracellular Stability Induced by ATP-Competitive and Novel Noncompetitive Abbapolin Inhibitors D Chapagai, G Merhej, C McInnes, MD Wyatt ACS Chemical Biology 18 (7), 1642-1652, 2023 | 7 | 2023 |
Biochemical Characterization of SBIP-470 and its role in SA-mediated Signaling in Plants DP Chapagai East Tennessee State University, 2014 | 3 | 2014 |
Abbapolins as inhibitors and degraders of polo-like kinases C McInnes, MD Wyatt, DP Chapagai, JM Stafford, G Ramamoorthy US Patent App. 18/304,048, 2023 | | 2023 |
Development of abbapolin inhibitors of the PLK1 PBD as potential therapeutics for prostate and other challenging cancers J Stafford, D Chapagai, G Merhej, J Pressley, C Nageswara-Rao, M Wyatt, ... Cancer Research 83 (7_Supplement), 4993-4993, 2023 | | 2023 |
A novel strategy for PLK1 kinase inhibition by allosterically targeting the Polo Box Domain D Chapagai, M Baxter, S Craig, G Ramamoorthy, J Stafford, S Vitali, ... Cancer Research 82 (12_Supplement), 2572-2572, 2022 | | 2022 |
Abbapolins as inhibitors and degraders of polo-like kinases MDW Danda Chapagai, Guru Ramamoorthy, C McInnes, J Varghese US Patent App. 63/332,919, 2022 | | 2022 |
Discovery and Mechanistic Study of Novel PBD-Targeted Inhibitors of PLK1 for Prostate Cancer Treatment DP Chapagai | | 2022 |
Converting high affinity peptides to non-peptidic inhibitors via REPLACE: Novel and new strategies in targeting PLK1 Polo Box Domain (PBD) for anti-cancer therapy D Chapagai, G Ramamoorthy, M Baxter, S Craig, E Nurmemmedov, ... Cancer Research 81 (13_Supplement), 1241-1241, 2021 | | 2021 |
Selective polo-like kinase 1 PBD inhibitor DP Chapagai, M Baxter, G Ramamoorthy, C McInnes, M Wyatt Cancer Research 79 (13_Supplement), 4712-4712, 2019 | | 2019 |
PAK6 localizes to centrosome and modulates centrosome homeostasis H Jia, D Chapagai, J Mallow, MD Perttunen, V Iragavarapu, J Wei, ML Lu Cancer Research 78 (13_Supplement), 3453-3453, 2018 | | 2018 |
Involvement of a Putative Lipid Transfer Protein, SBIP-470 in SA-Mediated Signaling DP Chapagai, DK David Donald, Bingqing Zhao 52nd Annual Meeting of the Phytochemical Society of North America, 2013 | | 2013 |
Characterization of a putative lipid transfer protein and its role in stress signaling of plants T Audam, DP Chapagain, D Kumar | | |