mTOR hyperactivity levels influence the severity of epilepsy and associated neuropathology in an experimental model of tuberous sclerosis complex and focal cortical dysplasia LH Nguyen, T Mahadeo, A Bordey Journal of Neuroscience 39 (14), 2762-2773, 2019 | 114 | 2019 |
mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia LH Nguyen, AL Brewster, ME Clark, A Regnier‐Golanov, CN Sunnen, ... Epilepsia 56 (4), 636-646, 2015 | 99 | 2015 |
Convergent and divergent mechanisms of epileptogenesis in mTORopathies LH Nguyen, A Bordey Frontiers in Neuroanatomy 15, 664695, 2021 | 48 | 2021 |
Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice LS Hsieh, JH Wen, LH Nguyen, L Zhang, SA Getz, J Torres-Reveron, ... Science Translational Medicine 12 (570), eabc1492, 2020 | 36 | 2020 |
Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations L Zhang, T Huang, S Teaw, LH Nguyen, LS Hsieh, X Gong, LH Burns, ... Science translational medicine 12 (531), eaay0289, 2020 | 35 | 2020 |
mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy LH Nguyen, AE Anderson Scientific Reports 8 (1), 3568, 2018 | 35 | 2018 |
Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy LH Nguyen, Y Xu, T Mahadeo, L Zhang, TV Lin, HA Born, AE Anderson, ... Brain 145 (4), 1310-1325, 2022 | 18 | 2022 |
The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function LH Nguyen, Y Xu, M Nair, A Bordey Elife 12, RP91010, 2024 | 15 | 2024 |
Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex LH Nguyen, SC Leiser, D Song, D Brunner, SL Roberds, M Wong, ... Epilepsy Research 181, 106890, 2022 | 10 | 2022 |
Current review in basic science: animal models of focal cortical dysplasia and epilepsy LH Nguyen, A Bordey Epilepsy Currents 22 (4), 234-240, 2022 | 8 | 2022 |
In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons T Huang, LH Nguyen, TV Lin, X Gong, L Zhang, GB Kim, MR Sarkisian, ... Neuroscience research 143, 44-52, 2019 | 4 | 2019 |
4E-BP1 expression in embryonic postmitotic neurons mitigates mTORC1-induced cortical malformations and behavioral seizure severity but does not prevent epilepsy in mice LH Nguyen, M Sharma, A Bordey Frontiers in Neuroscience 17, 1257056, 2023 | | 2023 |
Genetic expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy LH Nguyen, Y Xu, T Mahadeo, L Zhang, TV Lin, HA Born, AE Anderson, ... bioRxiv, 2021 | | 2021 |
Ectopic HCN4 expression drives mTOR-dependent epilepsy LS Hsieh, JH Wen, LH Nguyen, L Zhang, J Torres-Reveron, DD Spencer, ... bioRxiv, 853820, 2019 | | 2019 |
Roles of mTOR signaling in the maintenance of epilepsy and modulation of ion channels in a mouse model of cortical dysplasia LH Nguyen Baylor College of Medicine, 2016 | | 2016 |
The Role of MicroRNA Mmu-miR-691 in the Homeostatic Regulation of Potassium Channels in an in Vitro Seizure Model LH Nguyen University of Houston, 2009 | | 2009 |